Detail Information

Basic Information:


  VIRBase ID:  

VHID00463333

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9133

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-3p:           MCC:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-4-3p MCC
miRBase
Accession/Entrez ID		 MIMAT0002192 4163
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - MCC1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MCC
chr5:112529903(-) A-I      intronic
chr5:112529878(-) A-I      intronic
chr5:112529870(-) A-I      intronic
chr5:112527696(-) A-I      intronic
chr5:112753589(-) A-I      intronic
chr5:112753578(-) A-I      intronic
chr5:112659594(-) A-I      intronic
chr5:112529963(-) A-I      intronic
chr5:112648859(-) A-I      intronic
chr5:112639488(-) A-I      intronic
chr5:112380436(-) A-I      intronic
chr5:112380446(-) A-I      intronic
chr5:112380448(-) A-I      intronic
chr5:112381427(-) A-I      intronic
chr5:112380410(-) A-I      intronic
chr5:112649789(-) A-I      intronic
chr5:112373241(-) A-I      intronic
chr5:112371846(-) A-I      intronic
chr5:112612982(-) A-I      intronic
chr5:112381293(-) A-I      intronic
chr5:112381294(-) A-I      intronic
chr5:112381361(-) A-I      intronic
chr5:112381372(-) A-I      intronic
chr5:112671659(-) A-I      intronic
chr5:112671710(-) A-I      intronic
chr5:112381388(-) A-I      intronic
chr5:112381420(-) A-I      intronic
chr5:112429081(-) A-I      intronic
chr5:112381449(-) A-I      intronic
chr5:112371850(-) A-I      intronic
chr5:112643851(-) A-I      intronic
chr5:112646820(-) A-I      intronic
chr5:112708631(-) A-I      intronic
chr5:112382092(-) A-I      intronic
chr5:112817324(-) A-I      intronic
chr5:112817336(-) A-I      intronic
chr5:112382022(-) A-I      intronic
chr5:112381972(-) A-I      intronic
chr5:112381979(-) A-I      intronic
chr5:112382028(-) A-I      intronic
chr5:112382064(-) A-I      intronic
chr5:112382065(-) A-I      intronic
chr5:112382090(-) A-I      intronic
chr5:112382105(-) A-I      intronic
chr5:112382108(-) A-I      intronic
chr5:112427407(-) A-I      intronic
chr5:112427413(-) A-I      intronic
chr5:112470767(-) A-I      intronic
chr5:112522930(-) A-I      intronic
chr5:112542372(-) A-I      intronic
chr5:112561761(-) A-I      intronic
chr5:112561786(-) A-I      intronic
chr5:112561787(-) A-I      intronic
chr5:112612438(-) A-I      intronic
chr5:112612978(-) A-I      intronic
chr5:112381957(-) A-I      intronic
chr5:112369796(-) A-I      intronic
chr5:112373295(-) A-I      intronic
chr5:112371826(-) A-I      intronic
chr5:112443079(-) A-I      intronic
chr5:112556819(-) A-I      intronic
chr5:112556857(-) A-I      intronic
chr5:112561653(-) A-I      intronic
chr5:112637062(-) A-I      intronic
chr5:112371875(-) A-I      intronic
chr5:112371905(-) A-I      intronic
chr5:112373290(-) A-I      intronic
chr5:112373291(-) A-I      intronic
chr5:112373385(-) A-I      intronic
chr5:112380340(-) A-I      intronic
chr5:112380409(-) A-I      intronic
chr5:112381348(-) A-I      intronic
chr5:112381331(-) A-I      intronic
chr5:112470806(-) A-I      intronic
chr5:112382053(-) A-I      intronic
chr5:112366222(-) A-I      intronic
chr5:112371914(-) A-I      intronic
chr5:112470763(-) A-I      intronic
chr5:112381334(-) A-I      intronic
chr5:112382062(-) A-I      intronic
chr5:112580955(-) A-I      intronic
chr5:112382164(-) A-I      intronic
chr5:112366265(-) A-I      intronic
chr5:112612444(-) A-I      intronic
chr5:112366210(-) A-I      intronic
chr5:112361212(-) A-I      3'UTR
chr5:112623162(-) A-I      intronic
chr5:112522943(-) A-I      intronic
chr5:112442453(-) A-I      intronic
chr5:112522962(-) A-I      intronic
chr5:112371780(-) A-I      intronic
chr5:112470907(-) A-I      intronic
chr5:112536838(-) A-I      intronic
chr5:112470908(-) A-I      intronic
chr5:112381958(-) A-I      intronic
chr5:112556806(-) A-I      intronic
chr5:112381463(-) A-I      intronic
chr5:112371837(-) A-I      intronic
chr5:112612877(-) A-I      intronic
chr5:112373233(-) A-I      intronic
chr5:112612384(-) A-I      intronic
chr5:112470775(-) A-I      intronic
chr5:112381483(-) A-I      intronic
chr5:112381374(-) A-I      intronic
chr5:112789900(-) A-I      intronic
chr5:112522988(-) A-I      intronic
chr5:112373227(-) A-I      intronic
chr5:112643853(-) A-I      intronic
chr5:112382162(-) A-I      intronic
chr5:112382067(-) A-I      intronic
chr5:112633028(-) A-I      intronic
chr5:112371872(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MCC
chr5:112361106(-) C-G exon 3'UTR    22484847
chr5:112522943(-) A-G intron -    22484847
chr5:112522962(-) A-G intron -    22484847
chr5:112522988(-) A-G intron -    22484847
chr5:112556806(-) A-G intron -    22484847
chr5:112559993(-) A-G intron -    22484847
chr5:112580955(-) A-G intron -    22484847
chr5:112612869(-) T-C intron -    22484847
chr5:112612877(-) A-G intron -    22484847
chr5:112634979(-) C-T intron -    22484847
chr5:112634985(-) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MCC
chr5:112360096-112360097(-) m6A 3'UTR       24981863
chr5:112362763-112362764(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr5:112362815-112362816(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr5:112362870-112362871(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085
chr5:112362938-112362939(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr5:112362958-112362959(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr5:112363009-112363010(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr5:112363032-112363033(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr5:112363081-112363082(-) m6A CDS       24209618//24981863//27773535//22608085
chr5:112363088-112363089(-) m6A CDS       24209618//24981863//27773535//22608085
chr5:112363134-112363135(-) m6A CDS       24209618//24981863//27773535
chr5:112370634-112370635(-) m6A intron       27773535
chr5:112373540-112373541(-) m6A intron       27773535
chr5:112373679-112373680(-) m6A intron       27773535
chr5:112373925-112373926(-) m6A intron       27773535
chr5:112373957-112373958(-) m6A intron       27773535
chr5:112374155-112374156(-) m6A intron       27773535
chr5:112399801-112399802(-) m6A CDS       27773536
chr5:112399842-112399843(-) m6A CDS       27773536
chr5:112420991-112420992(-) m6A CDS       24284625//24209618
chr5:112437451-112437452(-) m6A CDS//exon       27773535
chr5:112437488-112437489(-) m6A CDS//exon       24284625//25456834//27773535
chr5:112437493-112437494(-) m6A CDS//exon       24284625//25456834//27773535
chr5:112437498-112437499(-) m6A CDS//exon       24284625//25456834//27773535
chr5:112437607-112437608(-) m6A CDS//exon       25456834//27773535
chr5:112439943-112439944(-) m6A CDS//exon       27773535//27773536
chr5:112440026-112440027(-) m6A CDS//exon       27773535//27773536
chr5:112440033-112440034(-) m6A CDS//exon       27773535//27773536
chr5:112440051-112440052(-) m6A CDS//exon       27773535//27773536
chr5:112440104-112440105(-) m6A exon//intron       27773536
chr5:112458409-112458410(-) m6A CDS//exon       27773536
chr5:112458431-112458432(-) m6A CDS//exon       27773535//27773536
chr5:112458436-112458437(-) m6A CDS//exon       27773535//27773536
chr5:112458442-112458443(-) m6A CDS//exon       27773535//27773536
chr5:112458457-112458458(-) m6A CDS//exon       27773535//27773536
chr5:112458489-112458490(-) m6A CDS//exon       27773535
chr5:112458501-112458502(-) m6A CDS//exon       27773535
chr5:112478938-112478939(-) m6A CDS//exon       27773535
chr5:112487036-112487037(-) m6A 5'UTR//CDS//exon       27773535
chr5:112487052-112487053(-) m6A 5'UTR//CDS//exon       27773535
chr5:112487074-112487075(-) m6A 5'UTR//CDS//exon       27773535
chr5:112538950-112538951(-) m6A exon//intron       27773535
chr5:112630608-112630609(-) m6A 5'UTR//intron       24981863
chr5:112630641-112630642(-) m6A 5'UTR//intron       24981863
chr5:112783946-112783947(-) m6A exon//intron       24209618
chr5:112824263-112824264(-) m6A 5'UTR//exon       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MCC
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug kshv-miR-K12-4-3p
Panobinostat       6918837
Nilotinib       644241
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Dovitinib       135398510
Crizotinib       11626560
Nvp-aew541       11476171
Pha-665752       10461815

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-4-3p
Interactor2: MCC

Evidence Support:


Strong-Evidence 3'UTR indicator assay
Weak-Evidence Microarray//PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


[1]PMID 23170179 Target region 3'UTR
Source RepTar//ViRBase Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells//BJAB cells Interactor2 expression None
Description Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP) (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays.
[2]PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells//BJAB cells Interactor2 expression None
Description Thirty-six combinations of 3'UTR indicators and KSHV miRNAs with PAR-CLIP interactions were tested for regulation. Nine of these interactions were independently also predicted by microarray analysis of the BJAB cell pools expressing miR-K1, miR-K4-3p, or miR-K11 described above (i.e. for miR-K1: NMI, RAD21, BCL11A, RFXAP; for miR-K4-3p: TPD52, GRB2, MCC, YWHAB; for miR-K11: WEE1). Targets were representative of the full range of seed match types observed in the libraries (Tables S6 and S11).

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