Basic Information:

  VIRBase ID:  

VHID00462559

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-5p:  MIMAT0002191          SPIN3:  NR_027139     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-5p	SPIN3
miRBase Accession/Entrez ID	MIMAT0002191	169981
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	bA445O16.1//SPIN-3//TDRD27

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SPIN3	chrX:57003364-57003365(-) m6A 3'UTR       27773535 chrX:57003373-57003374(-) m6A 3'UTR       27773535 chrX:57003385-57003386(-) m6A 3'UTR       27773535 chrX:57003421-57003422(-) m6A 3'UTR       27773535 chrX:57020479-57020480(-) Y intron       26075521 chrX:57020611-57020612(-) m6A CDS//intron       22608085 chrX:57020675-57020676(-) m6A CDS//intron       24209618//24981863//27371828//22608085 chrX:57020707-57020708(-) m6A CDS//intron       24209618//25456834//24981863//27773535//27371828//22608085 chrX:57020744-57020745(-) m6A CDS//intron       24209618//25456834//24981863//27773535//27371828//22608085 chrX:57020760-57020761(-) m6A CDS//intron       24209618//25456834//24981863//27773535//27371828//22608085 chrX:57020904-57020905(-) m6A CDS//intron       24209618//22608085 chrX:57020965-57020966(-) m6A CDS//intron       24209618//24981863//27773535//22575960//22608085 chrX:57020978-57020979(-) m6A CDS//intron       24209618//24981863//27773535//22575960//22608085 chrX:57021089-57021090(-) m6A CDS//intron       24284625//24981863//27773535//22608085 chrX:57021169-57021170(-) m6A CDS       24284625 chrX:57021191-57021192(-) m6A CDS       24284625//24981863 chrX:57021237-57021238(-) m6A CDS       24981863 chrX:57021816-57021817(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SPIN3	Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-5p
Interactor2: SPIN3

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).