Basic Information:

  VIRBase ID:  

VHID00462229

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-5p:  MIMAT0002191          OBI1:  NM_024546     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-5p	OBI1
miRBase Accession/Entrez ID	MIMAT0002191	79596
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C13orf7//RNF219

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OBI1	chr13:79230476(-) A-I      intronic chr13:79231193(-) A-I      intronic chr13:79208705(-) A-I      intronic chr13:79208568(-) A-I      intronic chr13:79230474(-) A-I      intronic chr13:79230475(-) A-I      intronic chr13:79208574(-) A-I      intronic chr13:79208664(-) A-I      intronic chr13:79208628(-) A-I      intronic chr13:79208721(-) A-I      intronic chr13:79208635(-) A-I      intronic chr13:79208567(-) A-I      intronic chr13:79208659(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	OBI1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-5p
Interactor2: OBI1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).