Basic Information:

  VIRBase ID:  

VHID00461413

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-4-5p:  MIMAT0002191          PIP4K2B:  NM_003559     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-4-5p	PIP4K2B
miRBase Accession/Entrez ID	MIMAT0002191	8396
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PI5P4KB//PIP5K2B//PIP5KIIB//PIP5KIIbeta//PIP5P4KB

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIP4K2B	chr17:36943471(-) A-I      intronic chr17:36943517(-) A-I      intronic chr17:36933370(-) A-I      intronic chr17:36951921(-) A-I      intronic chr17:36933355(-) A-I      intronic chr17:36943458(-) A-I      intronic chr17:36943462(-) A-I      intronic chr17:36949881(-) A-I      intronic chr17:36933348(-) A-I      intronic chr17:36933347(-) A-I      intronic chr17:36928171(-) A-I      intronic chr17:36933378(-) A-I      intronic chr17:36944102(-) A-I      intronic chr17:36928937(-) A-I      intronic chr17:36928932(-) A-I      intronic chr17:36940026(-) A-I      intronic chr17:36941681(-) A-I      intronic chr17:36941747(-) A-I      intronic chr17:36943341(-) A-I      intronic chr17:36943545(-) A-I      intronic chr17:36944097(-) A-I      intronic chr17:36947803(-) A-I      intronic chr17:36944575(-) A-I      intronic chr17:36944582(-) A-I      intronic chr17:36944586(-) A-I      intronic chr17:36944656(-) A-I      intronic chr17:36928139(-) A-I      intronic chr17:36945084(-) A-I      intronic chr17:36945119(-) A-I      intronic chr17:36928127(-) A-I      intronic chr17:36928064(-) A-I      intronic chr17:36931669(-) A-I      intronic chr17:36945253(-) A-I      intronic chr17:36950015(-) A-I      intronic chr17:36948590(-) A-I      intronic chr17:36948624(-) A-I      intronic chr17:36949716(-) A-I      intronic chr17:36949734(-) A-I      intronic chr17:36950092(-) A-I      intronic chr17:36949748(-) A-I      intronic chr17:36950075(-) A-I      intronic chr17:36943958(-) A-I      intronic chr17:36945285(-) A-I      intronic chr17:36946674(-) A-I      intronic chr17:36946991(-) A-I      intronic chr17:36946999(-) A-I      intronic chr17:36947768(-) A-I      intronic chr17:36947787(-) A-I      intronic chr17:36947800(-) A-I      intronic chr17:36947801(-) A-I      intronic chr17:36950079(-) A-I      intronic chr17:36947856(-) A-I      intronic chr17:36947895(-) A-I      intronic chr17:36947926(-) A-I      intronic chr17:36948225(-) A-I      intronic chr17:36948237(-) A-I      intronic chr17:36948286(-) A-I      intronic chr17:36948323(-) A-I      intronic chr17:36948548(-) A-I      intronic chr17:36932380(-) A-I      intronic chr17:36932420(-) A-I      intronic chr17:36932770(-) A-I      intronic chr17:36933425(-) A-I      intronic chr17:36933514(-) A-I      intronic chr17:36937830(-) A-I      intronic chr17:36937862(-) A-I      intronic chr17:36938059(-) A-I      intronic chr17:36939250(-) A-I      intronic chr17:36939329(-) A-I      intronic chr17:36939336(-) A-I      intronic chr17:36939348(-) A-I      intronic chr17:36939391(-) A-I      intronic chr17:36939916(-) A-I      intronic chr17:36944726(-) A-I      intronic chr17:36939919(-) A-I      intronic chr17:36932352(-) A-I      intronic chr17:36932104(-) A-I      intronic chr17:36931791(-) A-I      intronic chr17:36931629(-) A-I      intronic chr17:36930899(-) A-I      intronic chr17:36928967(-) A-I      intronic chr17:36945366(-) A-I      intronic chr17:36928079(-) A-I      intronic chr17:36945286(-) A-I      intronic chr17:36939259(-) A-I      intronic chr17:36946849(-) A-I      intronic chr17:36952345(-) A-I      intronic chr17:36932796(-) A-I      intronic chr17:36931759(-) A-I      intronic chr17:36948175(-) A-I      intronic chr17:36941677(-) A-I      intronic chr17:36931773(-) A-I      intronic chr17:36932362(-) A-I      intronic chr17:36943968(-) A-I      intronic chr17:36939273(-) A-I      intronic chr17:36928242(-) A-I      intronic chr17:36946742(-) A-I      intronic chr17:36949634(-) A-I      intronic chr17:36943324(-) A-I      intronic chr17:36945277(-) A-I      intronic chr17:36949764(-) A-I      intronic chr17:36952002(-) A-I      intronic chr17:36945344(-) A-I      intronic chr17:36945309(-) A-I      intronic chr17:36949234(-) A-I      intronic chr17:36931479(-) A-I      intronic chr17:36932361(-) A-I      intronic chr17:36933526(-) A-I      intronic chr17:36946989(-) A-I      intronic chr17:36948227(-) A-I      intronic chr17:36948305(-) A-I      intronic chr17:36944853(-) A-I      intronic chr17:36939888(-) A-I      intronic chr17:36945250(-) A-I      intronic chr17:36929012(-) A-I      intronic chr17:36937898(-) A-I      intronic chr17:36950081(-) A-I      intronic chr17:36949873(-) A-I      intronic chr17:36929006(-) A-I      intronic chr17:36951841(-) A-I      intronic chr17:36933414(-) A-I      intronic chr17:36949907(-) A-I      intronic chr17:36932028(-) A-I      intronic chr17:36939276(-) A-I      intronic chr17:36947759(-) A-I      intronic chr17:36944637(-) A-I      intronic chr17:36933590(-) A-I      intronic chr17:36944565(-) A-I      intronic chr17:36945122(-) A-I      intronic chr17:36928038(-) A-I      intronic chr17:36938056(-) A-I      intronic chr17:36949319(-) A-I      intronic chr17:36949956(-) A-I      intronic chr17:36944862(-) A-I      intronic chr17:36931699(-) A-I      intronic chr17:36939853(-) A-I      intronic chr17:36948302(-) A-I      intronic chr17:36939921(-) A-I      intronic chr17:36949867(-) A-I      intronic chr17:36929113(-) A-I      intronic chr17:36950042(-) A-I      intronic chr17:36928221(-) A-I      intronic chr17:36949994(-) A-I      intronic chr17:36949880(-) A-I      intronic chr17:36947866(-) A-I      intronic chr17:36946996(-) A-I      intronic chr17:36939324(-) A-I      intronic chr17:36929129(-) A-I      intronic chr17:36944847(-) A-I      intronic chr17:36948462(-) A-I      intronic chr17:36950078(-) A-I      intronic chr17:36937908(-) A-I      intronic chr17:36932495(-) A-I      intronic chr17:36950056(-) A-I      intronic chr17:36931478(-) A-I      intronic chr17:36944865(-) A-I      intronic chr17:36945260(-) A-I      intronic chr17:36943417(-) A-I      intronic chr17:36945019(-) A-I      intronic chr17:36944717(-) A-I      intronic chr17:36946695(-) A-I      intronic chr17:36928128(-) A-I      intronic chr17:36928077(-) A-I      intronic chr17:36938206(-) A-I      intronic chr17:36947935(-) A-I      intronic chr17:36931683(-) A-I      intronic chr17:36939196(-) A-I      intronic chr17:36951882(-) A-I      intronic chr17:36929070(-) A-I      intronic chr17:36928244(-) A-I      intronic chr17:36943538(-) A-I      intronic chr17:36947698(-) A-I      intronic chr17:36948313(-) A-I      intronic chr17:36938190(-) A-I      intronic chr17:36944866(-) A-I      intronic chr17:36928078(-) A-I      intronic chr17:36948086(-) A-I      intronic chr17:36948564(-) A-I      intronic chr17:36943459(-) A-I      intronic chr17:36932880(-) A-I      intronic chr17:36950093(-) A-I      intronic chr17:36938049(-) A-I      intronic chr17:36939184(-) A-I      intronic chr17:36949305(-) A-I      intronic chr17:36943984(-) A-I      intronic chr17:36950002(-) A-I      intronic chr17:36932822(-) A-I      intronic chr17:36943944(-) A-I      intronic chr17:36928999(-) A-I      intronic chr17:36937803(-) A-I      intronic chr17:36945256(-) A-I      intronic chr17:36946749(-) A-I      intronic chr17:36950067(-) A-I      intronic chr17:36944592(-) A-I      intronic chr17:36948454(-) A-I      intronic chr17:36945324(-) A-I      intronic chr17:36949673(-) A-I      intronic chr17:36928269(-) A-I      intronic chr17:36943509(-) A-I      intronic chr17:36949565(-) A-I      intronic chr17:36952226(-) A-I      intronic chr17:36949635(-) A-I      intronic chr17:36949306(-) A-I      intronic chr17:36945124(-) A-I      intronic chr17:36932816(-) A-I      intronic chr17:36933517(-) A-I      intronic chr17:36951941(-) A-I      intronic chr17:36928167(-) A-I      intronic chr17:36933584(-) A-I      intronic chr17:36933455(-) A-I      intronic chr17:36949879(-) A-I      intronic chr17:36948540(-) A-I      intronic chr17:36940762(-) A-I      intronic chr17:36945094(-) A-I      intronic chr17:36952269(-) A-I      intronic chr17:36944249(-) A-I      intronic chr17:36928931(-) A-I      intronic chr17:36950012(-) A-I      intronic chr17:36949757(-) A-I      intronic chr17:36949906(-) A-I      intronic chr17:36947934(-) A-I      intronic chr17:36940688(-) A-I      intronic chr17:36944117(-) A-I      intronic chr17:36949249(-) A-I      intronic chr17:36948474(-) A-I      intronic chr17:36938120(-) A-I      intronic chr17:36933279(-) A-I      intronic chr17:36929034(-) A-I      intronic chr17:36949967(-) A-I      intronic chr17:36937747(-) A-I      intronic chr17:36948098(-) A-I      intronic chr17:36940720(-) A-I      intronic chr17:36946683(-) A-I      intronic chr17:36931501(-) A-I      intronic chr17:36945697(-) A-I      intronic chr17:36928231(-) A-I      intronic chr17:36945367(-) A-I      intronic chr17:36950024(-) A-I      intronic chr17:36941680(-) A-I      intronic chr17:36943421(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIP4K2B	chr17:36928079(-) A-G intron -    22484847 chr17:36929006(-) A-G intron -    22484847 chr17:36932317(-) C-T intron -    22484847 chr17:36932495(-) A-G intron -    22484847 chr17:36943421(-) A-G intron -    22484847 chr17:36946996(-) A-G intron -    22484847 chr17:36948462(-) A-G intron -    22484847 chr17:36950012(-) A-G intron -    22484847 chr17:36950024(-) A-G intron -    22484847 chr17:36950081(-) A-G intron -    22484847 chr17:36950093(-) A-G intron -    22484847 chr17:36952345(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIP4K2B	chr17:36924027-36924028(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:36924071-36924072(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr17:36924092-36924093(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr17:36924099-36924100(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr17:36924119-36924120(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr17:36924133-36924134(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr17:36924175-36924176(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr17:36924204-36924205(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr17:36924235-36924236(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr17:36924302-36924303(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:36924332-36924333(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:36924375-36924376(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:36924398-36924399(-) Am 3'UTR       - chr17:36924415-36924416(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:36924444-36924445(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:36924508-36924509(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:36924541-36924542(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:36924638-36924639(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:36924860-36924861(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:36924911-36924912(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr17:36924997-36924998(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:36925006-36925007(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:36925042-36925043(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr17:36925068-36925069(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27371828//22575960//22608085 chr17:36925161-36925162(-) m6A 3'UTR       24284625//24209618//24981863//27371828//22575960//22608085 chr17:36925179-36925180(-) m6A 3'UTR       24284625//24209618//24981863//27371828//22575960//22608085 chr17:36925318-36925319(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27371828//22608085 chr17:36925418-36925419(-) m6A 3'UTR       24284625//24209618//24981863//22608085 chr17:36925453-36925454(-) m6A 3'UTR       24284625//24209618//24981863//22608085 chr17:36925477-36925478(-) m6A 3'UTR       24284625//24209618//24981863 chr17:36925785-36925786(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:36925810-36925811(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960 chr17:36925998-36925999(-) m6A CDS       24209618//24981863//27773535//27371828 chr17:36926694-36926695(-) m6A CDS       24209618//24981863//27773535 chr17:36927358-36927359(-) m6A CDS       27371828 chr17:36927466-36927467(-) m6A CDS//exon       24209618//25456834//24981863//27773535//27371828 chr17:36927499-36927500(-) m6A CDS//exon       24209618//25456834//24981863//27773535//27371828 chr17:36933957-36933958(-) m6A CDS//exon       24209618//24981863//27773535//27371828//22575960 chr17:36933970-36933971(-) m6A CDS//exon       24209618//24981863//27773535//27371828//22575960 chr17:36934027-36934028(-) m6A CDS//exon       24981863//27773535//27371828 chr17:36934045-36934046(-) m6A CDS//exon       24981863//27773535//27371828 chr17:36935703-36935704(-) m6A CDS//exon       27773535 chr17:36955525-36955526(-) m6A CDS//exon//intron       24209618 chr17:36955601-36955602(-) m1A CDS//exon//intron       26863410//26863196 chr17:36955610-36955611(-) m6A CDS//exon//intron       24284625//24209618//27371828 chr17:36955616-36955617(-) m6A CDS//exon//intron       24284625//24209618//27371828 chr17:36955831-36955832(-) m6A 5'UTR//intron       24981863 chr17:36955926-36955927(-) m6A 5'UTR//intron       27371828//27773536 chr17:36956140-36956141(-) m6A 5'UTR//intron       25456834//24981863//27371828//27773536 chr17:36956284-36956285(-) m6A 5'UTR       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PIP4K2B	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-4-5p
Interactor2: PIP4K2B

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.