Basic Information:

  VIRBase ID:  

VHID00459605

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-5-3p:  MIMAT0002190          TMX4:  NM_021156     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-5-3p	TMX4
miRBase Accession/Entrez ID	MIMAT0002190	56255
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DJ971N18.2//PDIA14//TXNDC13

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMX4	chr20:7958386-7958387(-) m6A 3'UTR       24981863//27773535//22608085 chr20:7958494-7958495(-) m6A 3'UTR       24209618//24981863//27773535//22608085 chr20:7958537-7958538(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr20:7958575-7958576(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr20:7958595-7958596(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr20:7958617-7958618(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr20:7960750-7960751(-) m6A 3'UTR       27773535 chr20:7960773-7960774(-) m6A 3'UTR       27773535 chr20:7960794-7960795(-) m6A 3'UTR       27773535 chr20:7962088-7962089(-) m6A 3'UTR       24981863//27773535//22608085 chr20:7962116-7962117(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr20:7962148-7962149(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr20:7962221-7962222(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr20:7962248-7962249(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr20:7962577-7962578(-) m6A 3'UTR       24981863//22575960 chr20:7962654-7962655(-) m6A 3'UTR       24981863//22575960 chr20:7962666-7962667(-) m6A 3'UTR       24981863 chr20:7962695-7962696(-) m6A 3'UTR       24981863 chr20:7962862-7962863(-) m6A 3'UTR       24209618//24981863//28052920//26404942//27773535//22608085 chr20:7962903-7962904(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:7962943-7962944(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr20:7962991-7962992(-) m1A CDS       26863196 chr20:7963099-7963100(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr20:7963111-7963112(-) m1A CDS       26863196 chr20:7963153-7963154(-) m1A CDS       26863196 chr20:7963174-7963175(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr20:7963180-7963181(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr20:7963186-7963187(-) m1A CDS       26863196 chr20:7963230-7963231(-) m6A CDS       24209618//24981863//27773535//27371828//22608085 chr20:8000340-8000341(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TMX4	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-5-3p
Interactor2: TMX4

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).