Basic Information:

  VIRBase ID:  

VHID00459303

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-5-3p:  MIMAT0002190          COX16:  NM_001204090     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-5-3p	COX16
miRBase Accession/Entrez ID	MIMAT0002190	51241
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C14orf112//hCOX16//HSPC203

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	COX16	chr14:70818788(-) A-I      intronic chr14:70818774(-) A-I      intronic chr14:70818759(-) A-I      intronic chr14:70818746(-) A-I      intronic chr14:70804021(-) A-I      intronic chr14:70804039(-) A-I      intronic chr14:70804016(-) A-I      intronic chr14:70804040(-) A-I      intronic chr14:70797863(-) A-I      intronic chr14:70797822(-) A-I      intronic chr14:70797839(-) A-I      intronic chr14:70801048(-) A-I      intronic chr14:70819932(-) A-I      intronic chr14:70801128(-) A-I      intronic chr14:70797834(-) A-I      intronic chr14:70819793(-) A-I      intronic chr14:70819963(-) A-I      intronic chr14:70809129(-) A-I      intronic chr14:70819825(-) A-I      intronic chr14:70819902(-) A-I      intronic chr14:70819921(-) A-I      intronic chr14:70802784(-) A-I      intronic chr14:70819001(-) A-I      intronic chr14:70802779(-) A-I      intronic chr14:70819895(-) A-I      intronic chr14:70805096(-) A-I      intronic chr14:70820328(-) A-I      intronic chr14:70818969(-) A-I      intronic chr14:70819599(-) A-I      intronic chr14:70797996(-) A-I      intronic chr14:70819655(-) A-I      intronic chr14:70820333(-) A-I      intronic chr14:70819122(-) A-I      intronic chr14:70818692(-) A-I      intronic chr14:70805007(-) A-I      intronic chr14:70819900(-) A-I      intronic chr14:70797879(-) A-I      intronic chr14:70820350(-) A-I      intronic chr14:70819942(-) A-I      intronic chr14:70805018(-) A-I      intronic chr14:70819368(-) A-I      intronic chr14:70797821(-) A-I      intronic chr14:70820410(-) A-I      intronic chr14:70797873(-) A-I      intronic chr14:70797933(-) A-I      intronic chr14:70804928(-) A-I      intronic chr14:70819098(-) A-I      intronic chr14:70819649(-) A-I      intronic chr14:70809014(-) A-I      intronic chr14:70792131(-) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	COX16	chr14:70791909-70791910(-) m6A 3'UTR       27773535 chr14:70791997-70791998(-) m6A 3'UTR       27773535 chr14:70826261-70826262(-) m6A CDS//exon       24981863 chr14:70826266-70826267(-) m6A CDS//exon       24981863 chr14:70826436-70826437(-) m6A 5'UTR       24284625//25456834//24981863//27773535//27371828//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	COX16	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-5-3p
Interactor2: COX16

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).