Detail Information

Basic Information:


  VIRBase ID:  

VHID00459227

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-5-3p:           TMEM97:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-5-3p TMEM97
miRBase
Accession/Entrez ID		 MIMAT0002190 27346
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - MAC30//sigma2R

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMEM97
chr17:26654244(+) A-I      3'UTR
chr17:26654249(+) A-I      3'UTR
chr17:26650903(+) A-I      intronic
chr17:26650566(+) A-I      intronic
chr17:26650806(+) A-I      intronic
chr17:26654225(+) A-I      3'UTR
chr17:26654121(+) A-I      3'UTR
chr17:26654072(+) A-I      3'UTR
chr17:26650558(+) A-I      intronic
chr17:26654271(+) A-I      3'UTR
chr17:26654232(+) A-I      3'UTR
chr17:26654117(+) A-I      3'UTR
chr17:26654113(+) A-I      3'UTR
chr17:26654008(+) A-I      3'UTR
chr17:26650987(+) A-I      intronic
chr17:26650705(+) A-I      intronic
chr17:26650965(+) A-I      intronic
chr17:26654127(+) A-I      3'UTR
chr17:26654137(+) A-I      3'UTR
chr17:26654231(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMEM97
chr17:26654232(+) A-I intron -    21960545
chr17:26654113(+) A-G intron -    22484847
chr17:26654121(+) A-G intron -    22484847
chr17:26654137(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMEM97
chr17:26652535-26652536(+) m6A 5'UTR//CDS//intron       24284625
chr17:26652568-26652569(+) m6A 5'UTR//CDS//intron       24284625
chr17:26652829-26652830(+) m6A 3'UTR//intron       24284625//24209618//22608085
chr17:26653579-26653580(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653680-26653681(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653686-26653687(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653693-26653694(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr17:26653824-26653825(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653887-26653888(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653899-26653900(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653924-26653925(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26653963-26653964(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr17:26653973-26653974(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654009-26654010(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654123-26654124(+) m6A 3'UTR       24209618//24981863
chr17:26654183-26654184(+) m6A 3'UTR       24209618
chr17:26654280-26654281(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr17:26654299-26654300(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr17:26654328-26654329(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085
chr17:26654436-26654437(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654441-26654442(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654448-26654449(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654459-26654460(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:26654520-26654521(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:26655132-26655133(+) m6A 3'UTR       27773535
chr17:26655361-26655362(+) m6A 3'UTR       27773535
chr17:26655428-26655429(+) m6A 3'UTR       27773535
chr17:26655508-26655509(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr17:26655522-26655523(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TMEM97
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-5-3p
Interactor2: TMEM97

Evidence Support:


Weak-Evidence Microarray
Support Database ViRBase

References:


PMID 22174674 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line EA.hy926 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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