Basic Information:

  VIRBase ID:  

VHID00457621

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-5-3p:  MIMAT0002190          APBA1:  NM_001163     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-5-3p	APBA1
miRBase Accession/Entrez ID	MIMAT0002190	320
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	D9S411E//LIN10//MINT1//X11//X11A//X11ALPHA

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	APBA1	chr9:72238178(-) A-I      intronic chr9:72048952(-) A-I      intronic chr9:72048825(-) A-I      intronic chr9:72048839(-) A-I      intronic chr9:72048843(-) A-I      intronic chr9:72238224(-) A-I      intronic chr9:72048865(-) A-I      intronic chr9:72048872(-) A-I      intronic chr9:72224859(-) A-I      intronic chr9:72238222(-) A-I      intronic chr9:72225150(-) A-I      intronic chr9:72238213(-) A-I      intronic chr9:72225228(-) A-I      intronic chr9:72238216(-) A-I      intronic chr9:72224852(-) A-I      intronic chr9:72284688(-) A-I      intronic chr9:72266665(-) A-I      intronic chr9:72267861(-) A-I      intronic chr9:72273363(-) A-I      intronic chr9:72189971(-) A-I      intronic chr9:72203979(-) A-I      intronic chr9:72049438(-) A-I      intronic chr9:72154914(-) A-I      intronic chr9:72224839(-) A-I      intronic chr9:72048907(-) A-I      intronic chr9:72048923(-) A-I      intronic chr9:72267763(-) A-I      intronic chr9:72267797(-) A-I      intronic chr9:72280790(-) A-I      intronic chr9:72217298(-) A-I      intronic chr9:72221475(-) A-I      intronic chr9:72204147(-) A-I      intronic chr9:72129776(-) A-I      intronic chr9:72229932(-) A-I      intronic chr9:72230004(-) A-I      intronic chr9:72207505(-) A-I      intronic chr9:72203956(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	APBA1	chr9:72076211(-) A-I intron -    19478186

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	APBA1	chr9:72130957-72130958(-) m6A CDS       24981863 chr9:72130975-72130976(-) m6A CDS       24981863 chr9:72131036-72131037(-) m6A CDS       24981863 chr9:72131042-72131043(-) m6A CDS       24981863 chr9:72131071-72131072(-) m6A CDS       24981863 chr9:72131230-72131231(-) m6A CDS       24981863 chr9:72131251-72131252(-) m6A CDS       24981863 chr9:72131320-72131321(-) m6A CDS       24981863 chr9:72131341-72131342(-) m6A CDS       24981863 chr9:72131794-72131795(-) m6A CDS       - chr9:72131857-72131858(-) m6A CDS       - chr9:72131950-72131951(-) m6A CDS       - chr9:72132015-72132016(-) m6A CDS       - chr9:72132121-72132122(-) m6A CDS       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	APBA1	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-5-3p
Interactor2: APBA1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).