Detail Information

Basic Information:


  VIRBase ID:  

VHID00456728

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-3p:           FAM107B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-6-3p FAM107B
miRBase
Accession/Entrez ID		 MIMAT0002189 83641
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - C10orf45//HITS

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FAM107B
chr10:14617425(-) A-I      intronic
chr10:14624544(-) A-I      intronic
chr10:14617384(-) A-I      intronic
chr10:14579734(-) A-I      intronic
chr10:14642903(-) A-I      intronic
chr10:14637604(-) A-I      intronic
chr10:14593363(-) A-I      intronic
chr10:14604017(-) A-I      intronic
chr10:14593394(-) A-I      intronic
chr10:14635657(-) A-I      intronic
chr10:14603857(-) A-I      intronic
chr10:14594606(-) A-I      intronic
chr10:14594610(-) A-I      intronic
chr10:14593317(-) A-I      intronic
chr10:14594667(-) A-I      intronic
chr10:14624553(-) A-I      intronic
chr10:14594728(-) A-I      intronic
chr10:14618302(-) A-I      intronic
chr10:14642829(-) A-I      intronic
chr10:14618343(-) A-I      intronic
chr10:14618346(-) A-I      intronic
chr10:14618442(-) A-I      intronic
chr10:14624556(-) A-I      intronic
chr10:14642823(-) A-I      intronic
chr10:14636441(-) A-I      intronic
chr10:14624560(-) A-I      intronic
chr10:14642777(-) A-I      intronic
chr10:14624465(-) A-I      intronic
chr10:14642747(-) A-I      intronic
chr10:14624468(-) A-I      intronic
chr10:14624472(-) A-I      intronic
chr10:14624473(-) A-I      intronic
chr10:14593228(-) A-I      intronic
chr10:14624481(-) A-I      intronic
chr10:14624893(-) A-I      intronic
chr10:14624504(-) A-I      intronic
chr10:14641636(-) A-I      intronic
chr10:14624541(-) A-I      intronic
chr10:14641634(-) A-I      intronic
chr10:14639935(-) A-I      intronic
chr10:14639837(-) A-I      intronic
chr10:14639825(-) A-I      intronic
chr10:14639821(-) A-I      intronic
chr10:14639764(-) A-I      intronic
chr10:14639703(-) A-I      intronic
chr10:14639691(-) A-I      intronic
chr10:14624548(-) A-I      intronic
chr10:14566124(-) A-I      intronic
chr10:14624880(-) A-I      intronic
chr10:14579752(-) A-I      intronic
chr10:14594746(-) A-I      intronic
chr10:14604003(-) A-I      intronic
chr10:14593371(-) A-I      intronic
chr10:14731876(-) A-I      intronic
chr10:14593381(-) A-I      intronic
chr10:14668683(-) A-I      intronic
chr10:14624571(-) A-I      intronic
chr10:14624581(-) A-I      intronic
chr10:14636446(-) A-I      intronic
chr10:14618522(-) A-I      intronic
chr10:14731879(-) A-I      intronic
chr10:14637522(-) A-I      intronic
chr10:14668641(-) A-I      intronic
chr10:14624610(-) A-I      intronic
chr10:14593386(-) A-I      intronic
chr10:14668686(-) A-I      intronic
chr10:14593423(-) A-I      intronic
chr10:14636283(-) A-I      intronic
chr10:14625039(-) A-I      intronic
chr10:14625003(-) A-I      intronic
chr10:14624936(-) A-I      intronic
chr10:14624928(-) A-I      intronic
chr10:14608961(-) A-I      intronic
chr10:14617429(-) A-I      intronic
chr10:14637521(-) A-I      intronic
chr10:14603856(-) A-I      intronic
chr10:14643057(-) A-I      intronic
chr10:14642753(-) A-I      intronic
chr10:14624922(-) A-I      intronic
chr10:14636391(-) A-I      intronic
chr10:14604057(-) A-I      intronic
chr10:14603895(-) A-I      intronic
chr10:14624557(-) A-I      intronic
chr10:14637603(-) A-I      intronic
chr10:14624648(-) A-I      intronic
chr10:14618322(-) A-I      intronic
chr10:14594745(-) A-I      intronic
chr10:14624998(-) A-I      intronic
chr10:14594618(-) A-I      intronic
chr10:14593245(-) A-I      intronic
chr10:14623731(-) A-I      intronic
chr10:14617381(-) A-I      intronic
chr10:14643038(-) A-I      intronic
chr10:14624828(-) A-I      intronic
chr10:14624555(-) A-I      intronic
chr10:14603922(-) A-I      intronic
chr10:14593271(-) A-I      intronic
chr10:14612679(-) A-I      intronic
chr10:14635617(-) A-I      intronic
chr10:14624937(-) A-I      intronic
chr10:14624999(-) A-I      intronic
chr10:14593285(-) A-I      intronic
chr10:14618431(-) A-I      intronic
chr10:14623695(-) A-I      intronic
chr10:14639783(-) A-I      intronic
chr10:14624551(-) A-I      intronic
chr10:14625048(-) A-I      intronic
chr10:14618321(-) A-I      intronic
chr10:14636288(-) A-I      intronic
chr10:14624820(-) A-I      intronic
chr10:14636408(-) A-I      intronic
chr10:14604064(-) A-I      intronic
chr10:14624819(-) A-I      intronic
chr10:14624445(-) A-I      intronic
chr10:14637592(-) A-I      intronic
chr10:14692517(-) A-I      intronic
chr10:14617308(-) A-I      intronic
chr10:14637624(-) A-I      intronic
chr10:14642736(-) A-I      intronic
chr10:14594773(-) A-I      intronic
chr10:14609044(-) A-I      intronic
chr10:14637625(-) A-I      intronic
chr10:14624487(-) A-I      intronic
chr10:14636387(-) A-I      intronic
chr10:14623807(-) A-I      intronic
chr10:14603846(-) A-I      intronic
chr10:14609095(-) A-I      intronic
chr10:14643055(-) A-I      intronic
chr10:14637517(-) A-I      intronic
chr10:14617474(-) A-I      intronic
chr10:14639780(-) A-I      intronic
chr10:14636421(-) A-I      intronic
chr10:14624657(-) A-I      intronic
chr10:14642750(-) A-I      intronic
chr10:14796043(-) A-I      intronic
chr10:14603989(-) A-I      intronic
chr10:14612628(-) A-I      intronic
chr10:14630223(-) A-I      intronic
chr10:14605609(-) A-I      intronic
chr10:14625017(-) A-I      intronic
chr10:14624840(-) A-I      intronic
chr10:14642965(-) A-I      intronic
chr10:14625002(-) A-I      intronic
chr10:14561836(-) A-I      3'UTR
chr10:14574725(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED FAM107B
chr10:14603846(-) A-I intron -    15342557
chr10:14603856(-) A-I intron -    15342557
chr10:14603857(-) A-I intron -    15342557
chr10:14603895(-) A-I intron -    15342557
chr10:14603922(-) A-I intron -    15342557
chr10:14603988(-) A-I intron -    15342557
chr10:14603989(-) A-I intron -    15342557
chr10:14604003(-) A-I intron -    15342557
chr10:14604057(-) A-I intron -    15342557
chr10:14604064(-) A-I intron -    15342557
chr10:14605573(-) A-I intron -    15342557
chr10:14605609(-) A-I intron -    15342557
chr10:14608961(-) A-I intron -    15342557
chr10:14609044(-) A-I intron -    15342557
chr10:14609095(-) A-I intron -    15342557
chr10:14609487(-) A-I intron -    15342557
chr10:14574725(-) A-I intron -    21960545
chr10:14641636(-) A-I intron -    21960545
chr10:14624445(-) A-G intron -    22484847
chr10:14624487(-) A-G intron -    22484847
chr10:14624553(-) A-G intron -    22484847
chr10:14624937(-) A-G intron -    22484847
chr10:14636283(-) A-G intron -    22484847
chr10:14636288(-) A-G intron -    22484847
chr10:14643038(-) A-G intron -    22484847
chr10:14643057(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FAM107B
chr10:14561325-14561326(-) m6A 3'UTR       24284625//26404942
chr10:14561359-14561360(-) m6A 3'UTR       24284625//22608085
chr10:14561889-14561890(-) m6A 3'UTR       26404942
chr10:14561924-14561925(-) m6A 3'UTR       26404942
chr10:14562006-14562007(-) m6A 3'UTR       26404942
chr10:14562081-14562082(-) m6A 3'UTR       -
chr10:14562222-14562223(-) m6A 3'UTR       26404942
chr10:14562365-14562366(-) m6A 3'UTR       26404942
chr10:14562704-14562705(-) m6A 3'UTR       26404942//27773535
chr10:14562796-14562797(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22608085
chr10:14562829-14562830(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:14562892-14562893(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:14562906-14562907(-) Gm 3'UTR       -
chr10:14562910-14562911(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:14562920-14562921(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:14562933-14562934(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:14562943-14562944(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:14562957-14562958(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:14563170-14563171(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr10:14563223-14563224(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr10:14563299-14563300(-) m6A 3'UTR//CDS//exon       24209618//24981863//28052920//26404942//27773535//22608085
chr10:14563944-14563945(-) Cm 3'UTR//CDS//exon       -
chr10:14563958-14563959(-) m6A 3'UTR//CDS//exon       24209618//24981863//28052920//27773535//22608085
chr10:14564000-14564001(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535
chr10:14564116-14564117(-) m6A exon//intron       27773535
chr10:14572350-14572351(-) m6A 3'UTR//CDS//exon       24981863//26404942//27773535
chr10:14572372-14572373(-) m6A 3'UTR//CDS//exon       24981863//26404942//27773535
chr10:14572382-14572383(-) m6A 3'UTR//CDS//exon       24981863//26404942//27773535
chr10:14572401-14572402(-) m6A 3'UTR//CDS//exon       24981863//26404942//27773535
chr10:14572419-14572420(-) m6A 3'UTR//CDS//exon       24981863//26404942//27773535
chr10:14572444-14572445(-) m6A 3'UTR//CDS//exon       24981863//26404942//27773535
chr10:14572483-14572484(-) m6A 3'UTR//5'UTR//CDS//exon       26404942//27773535
chr10:14574640-14574641(-) m6A 5'UTR//intron       27773535
chr10:14644551-14644552(-) m6A exon//intron       27773535
chr10:14644601-14644602(-) m6A exon//intron       27773535
chr10:14644744-14644745(-) m6A exon//intron       24981863//26404942
chr10:14644799-14644800(-) m6A exon//intron       24981863//26404942
chr10:14644808-14644809(-) m6A exon//intron       24981863//26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate FAM107B
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-6-3p
Interactor2: FAM107B

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase//VIRmiRNA

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells//BJAB cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

Starting a new search, please wait ...