Basic Information:

  VIRBase ID:  

VHID00456503

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-3p:  MIMAT0002189          ERAP2:  NR_137637     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-6-3p	ERAP2
miRBase Accession/Entrez ID	MIMAT0002189	64167
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	L-RAP//LRAP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ERAP2	chr5:96241731(+) A-I      intronic chr5:96241683(+) A-I      intronic chr5:96241477(+) A-I      intronic chr5:96243466(+) A-I      intronic chr5:96243440(+) A-I      intronic chr5:96243421(+) A-I      intronic chr5:96241459(+) A-I      intronic chr5:96241437(+) A-I      intronic chr5:96241356(+) A-I      intronic chr5:96223670(+) A-I      intronic chr5:96223669(+) A-I      intronic chr5:96243387(+) A-I      intronic chr5:96223664(+) A-I      intronic chr5:96223646(+) A-I      intronic chr5:96223605(+) A-I      intronic chr5:96242132(+) A-I      intronic chr5:96242136(+) A-I      intronic chr5:96242137(+) A-I      intronic chr5:96214412(+) A-I      intronic chr5:96212737(+) A-I      intronic chr5:96212702(+) A-I      intronic chr5:96245849(+) A-I      intronic chr5:96252976(+) A-I      intronic chr5:96252940(+) A-I      intronic chr5:96252915(+) A-I      intronic chr5:96252911(+) A-I      intronic chr5:96245827(+) A-I      intronic chr5:96245826(+) A-I      intronic chr5:96252875(+) A-I      intronic chr5:96252872(+) A-I      intronic chr5:96252833(+) A-I      intronic chr5:96252395(+) A-I      intronic chr5:96252309(+) A-I      intronic chr5:96245822(+) A-I      intronic chr5:96245818(+) A-I      intronic chr5:96242502(+) A-I      intronic chr5:96243336(+) A-I      intronic chr5:96242653(+) A-I      intronic chr5:96242634(+) A-I      intronic chr5:96242535(+) A-I      intronic chr5:96242516(+) A-I      intronic chr5:96242246(+) A-I      intronic chr5:96242211(+) A-I      intronic chr5:96242210(+) A-I      intronic chr5:96242088(+) A-I      intronic chr5:96242070(+) A-I      intronic chr5:96252297(+) A-I      intronic chr5:96252261(+) A-I      intronic chr5:96252185(+) A-I      intronic chr5:96251880(+) A-I      intronic chr5:96251840(+) A-I      intronic chr5:96251831(+) A-I      intronic chr5:96251772(+) A-I      intronic chr5:96251702(+) A-I      intronic chr5:96251698(+) A-I      intronic chr5:96251688(+) A-I      intronic chr5:96251665(+) A-I      intronic chr5:96242057(+) A-I      intronic chr5:96245848(+) A-I      intronic chr5:96245807(+) A-I      intronic chr5:96245787(+) A-I      intronic chr5:96245783(+) A-I      intronic chr5:96245770(+) A-I      intronic chr5:96245736(+) A-I      intronic chr5:96245712(+) A-I      intronic chr5:96243519(+) A-I      intronic chr5:96251804(+) A-I      intronic chr5:96242589(+) A-I      intronic chr5:96242576(+) A-I      intronic chr5:96242083(+) A-I      intronic chr5:96241402(+) A-I      intronic chr5:96242207(+) A-I      intronic chr5:96251778(+) A-I      intronic chr5:96242585(+) A-I      intronic chr5:96242075(+) A-I      intronic chr5:96242582(+) A-I      intronic chr5:96242071(+) A-I      intronic chr5:96242206(+) A-I      intronic chr5:96241753(+) A-I      intronic chr5:96243331(+) A-I      intronic chr5:96253447(+) A-I      3'UTR chr5:96253347(+) A-I      3'UTR chr5:96242577(+) A-I      intronic chr5:96242584(+) A-I      intronic chr5:96242100(+) A-I      intronic chr5:96241368(+) A-I      intronic chr5:96242682(+) A-I      intronic chr5:96223558(+) A-I      intronic chr5:96241378(+) A-I      intronic chr5:96242521(+) A-I      intronic chr5:96241389(+) A-I      intronic chr5:96242050(+) A-I      intronic chr5:96242534(+) A-I      intronic chr5:96242526(+) A-I      intronic chr5:96212853(+) A-I      intronic chr5:96242264(+) A-I      intronic chr5:96241406(+) A-I      intronic chr5:96242583(+) A-I      intronic chr5:96242192(+) A-I      intronic chr5:96242045(+) A-I      intronic chr5:96223105(+) A-I      intronic chr5:96241467(+) A-I      intronic chr5:96242021(+) A-I      intronic chr5:96241404(+) A-I      intronic chr5:96241740(+) A-I      intronic chr5:96242586(+) A-I      intronic chr5:96252379(+) A-I      intronic chr5:96241741(+) A-I      intronic chr5:96241374(+) A-I      intronic chr5:96242571(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ERAP2	chr5:96241685(+) A-I intron -    22327324 chr5:96242050(+) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ERAP2	chr5:96212170-96212171(+) m6A 5'UTR//intron       - chr5:96215298-96215299(+) m6A 5'UTR       24981863 chr5:96215340-96215341(+) m6A 5'UTR       24981863 chr5:96215427-96215428(+) m6A CDS       - chr5:96215657-96215658(+) m6A CDS       24284625//24981863 chr5:96215784-96215785(+) m6A CDS       24284625//24981863//22608085 chr5:96215796-96215797(+) m6A CDS       24284625//24981863//22608085 chr5:96215826-96215827(+) m6A CDS       24284625//24981863//22608085 chr5:96215853-96215854(+) m6A CDS       24284625//24981863//22608085 chr5:96215888-96215889(+) m6A CDS       24284625//24981863 chr5:96215944-96215945(+) m6A CDS       24981863 chr5:96215959-96215960(+) m6A CDS       24981863 chr5:96248386-96248387(+) m6A 3'UTR//CDS       - chr5:96248424-96248425(+) m6A 3'UTR//CDS       - chr5:96248445-96248446(+) m6A 3'UTR//CDS       - chr5:96248450-96248451(+) m6A 3'UTR//CDS       - chr5:96249029-96249030(+) m6A 3'UTR//CDS       - chr5:96249057-96249058(+) m6A 3'UTR//CDS       - chr5:96253222-96253223(+) m6A 3'UTR//CDS       24981863 chr5:96253285-96253286(+) m6A 3'UTR//CDS       24981863 chr5:96253409-96253410(+) m6A 3'UTR       24981863 chr5:96253432-96253433(+) m6A 3'UTR       24981863 chr5:96253530-96253531(+) m6A 3'UTR       - chr5:96253599-96253600(+) m6A 3'UTR       - chr5:96253669-96253670(+) m6A 3'UTR       - chr5:96253693-96253694(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ERAP2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-6-3p
Interactor2: ERAP2

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells//EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).