Basic Information:

  VIRBase ID:  

VHID00456082

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-3p:  MIMAT0002189          OTUD6B:  NM_016023     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-6-3p	OTUD6B
miRBase Accession/Entrez ID	MIMAT0002189	51633
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CGI-77//DUBA-5//DUBA5//IDDFSDA

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OTUD6B	chr8:92083424(+) A-I exon CDS    19478186 chr8:92083861(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OTUD6B	chr8:92082681-92082682(+) m1A 5'UTR//CDS//exon       26863196//26863410 chr8:92083462-92083463(+) m6A 5'UTR//CDS//exon       24981863//27773535 chr8:92083468-92083469(+) m6A 5'UTR//CDS//exon       24981863//27773535 chr8:92083480-92083481(+) m6A 5'UTR//CDS//exon       24981863//27773535 chr8:92086086-92086087(+) m6A 5'UTR//CDS//exon       24981863 chr8:92090644-92090645(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr8:92090660-92090661(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr8:92090678-92090679(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr8:92090702-92090703(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr8:92090717-92090718(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr8:92090814-92090815(+) m6A 3'UTR//CDS//exon       22608085 chr8:92090845-92090846(+) m6A 3'UTR//CDS//exon       22608085 chr8:92090866-92090867(+) m6A 3'UTR//CDS//exon       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	OTUD6B	Exosome Urine     25135963 Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-6-3p
Interactor2: OTUD6B

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).