Basic Information:

  VIRBase ID:  

VHID00455555

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-3p:  MIMAT0002189          SLC9A6:  NM_001379110     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-6-3p	SLC9A6
miRBase Accession/Entrez ID	MIMAT0002189	10479
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	MRSA//NHE6

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC9A6	chrX:135083375(+) A-I      intronic chrX:135073487(+) A-I      intronic chrX:135083353(+) A-I      intronic chrX:135083315(+) A-I      intronic chrX:135083314(+) A-I      intronic chrX:135083307(+) A-I      intronic chrX:135072961(+) A-I      intronic chrX:135123169(+) A-I      intronic chrX:135123186(+) A-I      intronic chrX:135121265(+) A-I      intronic chrX:135120003(+) A-I      intronic chrX:135119761(+) A-I      intronic chrX:135090600(+) A-I      intronic chrX:135114511(+) A-I      intronic chrX:135090661(+) A-I      intronic chrX:135090609(+) A-I      intronic chrX:135086348(+) A-I      intronic chrX:135086341(+) A-I      intronic chrX:135083245(+) A-I      intronic chrX:135083239(+) A-I      intronic chrX:135083231(+) A-I      intronic chrX:135082187(+) A-I      intronic chrX:135075807(+) A-I      intronic chrX:135075695(+) A-I      intronic chrX:135073497(+) A-I      intronic chrX:135113683(+) A-I      intronic chrX:135114433(+) A-I      intronic chrX:135113712(+) A-I      intronic chrX:135114363(+) A-I      intronic chrX:135114275(+) A-I      intronic chrX:135075791(+) A-I      intronic chrX:135115295(+) A-I      intronic chrX:135113738(+) A-I      intronic chrX:135124572(+) A-I      intronic chrX:135113748(+) A-I      intronic chrX:135121266(+) A-I      intronic chrX:135113653(+) A-I      intronic chrX:135115283(+) A-I      intronic chrX:135114361(+) A-I      intronic chrX:135113673(+) A-I      intronic chrX:135124517(+) A-I      intronic chrX:135076505(+) A-I      intronic chrX:135114258(+) A-I      intronic chrX:135089306(+) A-I      intronic chrX:135075827(+) A-I      intronic chrX:135121333(+) A-I      intronic chrX:135114493(+) A-I      intronic chrX:135076447(+) A-I      intronic chrX:135119928(+) A-I      intronic chrX:135087765(+) A-I      intronic chrX:135113757(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC9A6	chrX:135067826-135067827(+) Gm CDS       - chrX:135126618-135126619(+) m6A CDS//exon       - chrX:135126695-135126696(+) m6A CDS       24284625//25456834//24981863//22608085 chrX:135126702-135126703(+) m6A CDS       24284625//25456834//24981863//22608085 chrX:135126740-135126741(+) m6A CDS       24284625//25456834//24981863//22608085 chrX:135126782-135126783(+) m6A CDS       24284625//25456834//24981863//26404942//22608085 chrX:135126789-135126790(+) m6A CDS       24284625//25456834//24981863//26404942//22608085 chrX:135126805-135126806(+) m6A CDS       24284625//25456834//24981863//26404942//22608085 chrX:135126837-135126838(+) m6A CDS       24284625//25456834//24981863//26404942//22608085 chrX:135126867-135126868(+) m6A CDS       24981863//26404942//22608085 chrX:135128798-135128799(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:135128814-135128815(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:135128865-135128866(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chrX:135128900-135128901(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:135128950-135128951(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:135128954-135128955(+) m6A 3'UTR       - chrX:135128976-135128977(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:135128988-135128989(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:135129032-135129033(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chrX:135129043-135129044(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chrX:135129067-135129068(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chrX:135129177-135129178(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLC9A6	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-6-3p
Interactor2: SLC9A6

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).