Basic Information:

  VIRBase ID:  

VHID00454698

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-3p:  MIMAT0002189          HSPA1B:  NM_005346     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-6-3p	HSPA1B
miRBase Accession/Entrez ID	MIMAT0002189	3304
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSP70-1//HSP70-1B//HSP70-2//HSP70.1//HSP70.2//HSP72//HSPA1//HSX70

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HSPA1B	chr6:31795562(+) A-I      NonSyn:Arg->Gly

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HSPA1B	chr6:31795598-31795599(+) m6A 5'UTR       24284625//25456834//24981863//22575960//22608085 chr6:31795648-31795649(+) m6A 5'UTR       24284625//25456834//24981863//26404942//27371828//27773536//22575960//22608085 chr6:31795696-31795697(+) Cm 5'UTR       - chr6:31795896-31795897(+) m6A CDS       24981863 chr6:31795911-31795912(+) m6A CDS       24981863 chr6:31795920-31795921(+) m6A CDS       24981863 chr6:31797081-31797082(+) m6A CDS       24981863 chr6:31797423-31797424(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:31797431-31797432(+) m1A CDS       26863196 chr6:31797441-31797442(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:31797553-31797554(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:31797690-31797691(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:31797699-31797700(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:31797707-31797708(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:31797958-31797959(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	HSPA1B	Exosome Blood     - Nucleolus K562 cells     - Nucleus Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-6-3p
Interactor2: HSPA1B

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.