Basic Information:

  VIRBase ID:  

VHID00454514

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-3p:  MIMAT0002189          DCK:  NM_000788     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-6-3p	DCK
miRBase Accession/Entrez ID	MIMAT0002189	1633
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DCK	chr4:71871471(+) A-I      intronic chr4:71871482(+) A-I      intronic chr4:71871493(+) A-I      intronic chr4:71894224(+) A-I      intronic chr4:71887559(+) A-I      intronic chr4:71883914(+) A-I      intronic chr4:71883913(+) A-I      intronic chr4:71876747(+) A-I      intronic chr4:71871696(+) A-I      intronic chr4:71861812(+) A-I      intronic chr4:71894164(+) A-I      intronic chr4:71887647(+) A-I      intronic chr4:71887598(+) A-I      intronic chr4:71894476(+) A-I      intronic chr4:71894047(+) A-I      intronic chr4:71871439(+) A-I      intronic chr4:71894369(+) A-I      Syn:Gln->Gln chr4:71887491(+) A-I      intronic chr4:71861819(+) A-I      intronic chr4:71861713(+) A-I      intronic chr4:71871366(+) A-I      intronic chr4:71871402(+) A-I      intronic chr4:71894158(+) A-I      intronic chr4:71861042(+) A-I      intronic chr4:71894099(+) A-I      intronic chr4:71894127(+) A-I      intronic chr4:71864561(+) A-I      intronic chr4:71894811(+) A-I      intronic chr4:71894374(+) A-I      NonSyn:His->Arg

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DCK	chr4:71871366(+) A-G intron -    22484847 chr4:71871439(+) A-G intron -    22484847 chr4:71885509(+) A-T intron -    22484847 chr4:71887491(+) A-G intron -    22484847 chr4:71894369(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DCK	chr4:71859283-71859284(+) m6A 5'UTR//intron       24981863 chr4:71859399-71859400(+) m6A 5'UTR//intron       24981863 chr4:71859544-71859545(+) m6A 5'UTR       24284625 chr4:71859606-71859607(+) m6A CDS       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DCK	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-6-3p
Interactor2: DCK

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.