Basic Information:

  VIRBase ID:  

VHID00454425

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-3p:  MIMAT0002189          CALU:  NR_074086     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-6-3p	CALU
miRBase Accession/Entrez ID	MIMAT0002189	813
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CALU	chr7:128406164(+) A-I      intronic chr7:128406531(+) A-I      intronic chr7:128406622(+) A-I      intronic chr7:128386649(+) A-I      intronic chr7:128406050(+) A-I      intronic chr7:128406798(+) A-I      intronic chr7:128406072(+) A-I      intronic chr7:128403510(+) A-I      intronic chr7:128403505(+) A-I      intronic chr7:128403497(+) A-I      intronic chr7:128403491(+) A-I      intronic chr7:128403452(+) A-I      intronic chr7:128402942(+) A-I      intronic chr7:128402866(+) A-I      intronic chr7:128402838(+) A-I      intronic chr7:128402764(+) A-I      intronic chr7:128402760(+) A-I      intronic chr7:128392948(+) A-I      intronic chr7:128392936(+) A-I      intronic chr7:128392884(+) A-I      intronic chr7:128392839(+) A-I      intronic chr7:128392838(+) A-I      intronic chr7:128392778(+) A-I      intronic chr7:128391670(+) A-I      intronic chr7:128391262(+) A-I      intronic chr7:128390242(+) A-I      intronic chr7:128390237(+) A-I      intronic chr7:128390188(+) A-I      intronic chr7:128390167(+) A-I      intronic chr7:128390135(+) A-I      intronic chr7:128387102(+) A-I      intronic chr7:128386940(+) A-I      intronic chr7:128386938(+) A-I      intronic chr7:128386903(+) A-I      intronic chr7:128386647(+) A-I      intronic chr7:128386637(+) A-I      intronic chr7:128386473(+) A-I      intronic chr7:128385645(+) A-I      intronic chr7:128385622(+) A-I      intronic chr7:128385538(+) A-I      intronic chr7:128385424(+) A-I      intronic chr7:128384166(+) A-I      intronic chr7:128384153(+) A-I      intronic chr7:128383750(+) A-I      intronic chr7:128380984(+) A-I      intronic chr7:128406692(+) A-I      intronic chr7:128406666(+) A-I      intronic chr7:128406612(+) A-I      intronic chr7:128406583(+) A-I      intronic chr7:128402862(+) A-I      intronic chr7:128404395(+) A-I      intronic chr7:128404489(+) A-I      intronic chr7:128405076(+) A-I      intronic chr7:128405157(+) A-I      intronic chr7:128405204(+) A-I      intronic chr7:128405342(+) A-I      intronic chr7:128406111(+) A-I      intronic chr7:128409667(+) A-I      3'UTR chr7:128403336(+) A-I      intronic chr7:128391073(+) A-I      intronic chr7:128393013(+) A-I      intronic chr7:128392758(+) A-I      intronic chr7:128385544(+) A-I      intronic chr7:128384005(+) A-I      intronic chr7:128392868(+) A-I      intronic chr7:128390093(+) A-I      intronic chr7:128400699(+) A-I      intronic chr7:128391599(+) A-I      intronic chr7:128402906(+) A-I      intronic chr7:128391638(+) A-I      intronic chr7:128386401(+) A-I      intronic chr7:128392904(+) A-I      intronic chr7:128405121(+) A-I      intronic chr7:128405492(+) A-I      intronic chr7:128385548(+) A-I      intronic chr7:128399996(+) A-I      intronic chr7:128406110(+) A-I      intronic chr7:128392809(+) A-I      intronic chr7:128406064(+) A-I      intronic chr7:128405007(+) A-I      intronic chr7:128402850(+) A-I      intronic chr7:128404296(+) A-I      intronic chr7:128404321(+) A-I      intronic chr7:128403418(+) A-I      intronic chr7:128385585(+) A-I      intronic chr7:128385608(+) A-I      intronic chr7:128406151(+) A-I      intronic chr7:128403424(+) A-I      intronic chr7:128402995(+) A-I      intronic chr7:128386486(+) A-I      intronic chr7:128405449(+) A-I      intronic chr7:128406663(+) A-I      intronic chr7:128404372(+) A-I      intronic chr7:128405354(+) A-I      intronic chr7:128392832(+) A-I      intronic chr7:128383694(+) A-I      intronic chr7:128383732(+) A-I      intronic chr7:128386758(+) A-I      intronic chr7:128400089(+) A-I      intronic chr7:128386655(+) A-I      intronic chr7:128393005(+) A-I      intronic chr7:128386474(+) A-I      intronic chr7:128406030(+) A-I      intronic chr7:128384101(+) A-I      intronic chr7:128405368(+) A-I      intronic chr7:128404421(+) A-I      intronic chr7:128384004(+) A-I      intronic chr7:128392939(+) A-I      intronic chr7:128391088(+) A-I      intronic chr7:128386780(+) A-I      intronic chr7:128383689(+) A-I      intronic chr7:128404213(+) A-I      intronic chr7:128402814(+) A-I      intronic chr7:128391660(+) A-I      intronic chr7:128383716(+) A-I      intronic chr7:128383832(+) A-I      intronic chr7:128405125(+) A-I      intronic chr7:128404414(+) A-I      intronic chr7:128390026(+) A-I      intronic chr7:128403427(+) A-I      intronic chr7:128383820(+) A-I      intronic chr7:128406137(+) A-I      intronic chr7:128393006(+) A-I      intronic chr7:128386608(+) A-I      intronic chr7:128392922(+) A-I      intronic chr7:128405048(+) A-I      intronic chr7:128385532(+) A-I      intronic chr7:128404350(+) A-I      intronic chr7:128391283(+) A-I      intronic chr7:128404432(+) A-I      intronic chr7:128404437(+) A-I      intronic chr7:128405306(+) A-I      intronic chr7:128386329(+) A-I      intronic chr7:128405458(+) A-I      intronic chr7:128403422(+) A-I      intronic chr7:128403397(+) A-I      intronic chr7:128400708(+) A-I      intronic chr7:128390161(+) A-I      intronic chr7:128386351(+) A-I      intronic chr7:128386274(+) A-I      intronic chr7:128393018(+) A-I      intronic chr7:128384156(+) A-I      intronic chr7:128404342(+) A-I      intronic chr7:128402998(+) A-I      intronic chr7:128392878(+) A-I      intronic chr7:128406216(+) A-I      intronic chr7:128402860(+) A-I      intronic chr7:128392808(+) A-I      intronic chr7:128402901(+) A-I      intronic chr7:128391292(+) A-I      intronic chr7:128392789(+) A-I      intronic chr7:128402798(+) A-I      intronic chr7:128403436(+) A-I      intronic chr7:128391195(+) A-I      intronic chr7:128402930(+) A-I      intronic chr7:128393036(+) A-I      intronic chr7:128406762(+) A-I      intronic chr7:128403423(+) A-I      intronic chr7:128391221(+) A-I      intronic chr7:128404467(+) A-I      intronic chr7:128403464(+) A-I      intronic chr7:128406199(+) A-I      intronic chr7:128383626(+) A-I      intronic chr7:128400074(+) A-I      intronic chr7:128386962(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CALU	chr7:128392868(+) A-I intron -    15258596 chr7:128392873(+) A-I intron -    15258596 chr7:128392878(+) A-I intron -    15258596 chr7:128393006(+) A-I intron -    15258596 chr7:128393013(+) A-I intron -    15258596 chr7:128393018(+) A-I intron -    15258596 chr7:128384005(+) A-I intron -    22327324 chr7:128405306(+) A-I intron -    22327324 chr7:128391674(+) A-I intron -    21960545 chr7:128406110(+) A-I intron -    21960545 chr7:128406151(+) A-I intron -    21960545 chr7:128385418(+) A-I intron -    21960545 chr7:128390026(+) A-I intron -    21960545 chr7:128405007(+) A-I intron -    21960545 chr7:128405048(+) A-I intron -    21960545 chr7:128383694(+) A-G intron -    22484847 chr7:128383732(+) A-G intron -    22484847 chr7:128383991(+) A-G intron -    22484847 chr7:128384004(+) A-G intron -    22484847 chr7:128384005(+) A-G intron -    22484847 chr7:128384100(+) A-G intron -    22484847 chr7:128384101(+) A-G intron -    22484847 chr7:128384140(+) A-G intron -    22484847 chr7:128385419(+) A-G intron -    22484847 chr7:128385532(+) A-G intron -    22484847 chr7:128385562(+) A-G intron -    22484847 chr7:128386274(+) A-G intron -    22484847 chr7:128386401(+) A-G intron -    22484847 chr7:128386608(+) A-G intron -    22484847 chr7:128390003(+) A-G intron -    22484847 chr7:128390161(+) A-G intron -    22484847 chr7:128391089(+) A-G intron -    22484847 chr7:128391094(+) A-G intron -    22484847 chr7:128391195(+) A-G intron -    22484847 chr7:128391221(+) A-G intron -    22484847 chr7:128392808(+) A-G intron -    22484847 chr7:128392809(+) A-G intron -    22484847 chr7:128392832(+) A-G intron -    22484847 chr7:128392868(+) A-G intron -    22484847 chr7:128392873(+) A-G intron -    22484847 chr7:128392878(+) A-G intron -    22484847 chr7:128392904(+) A-G intron -    22484847 chr7:128392922(+) A-G intron -    22484847 chr7:128392939(+) A-G intron -    22484847 chr7:128393006(+) A-G intron -    22484847 chr7:128393013(+) A-G intron -    22484847 chr7:128402798(+) A-G intron -    22484847 chr7:128402814(+) A-G intron -    22484847 chr7:128402820(+) A-G intron -    22484847 chr7:128402860(+) A-G intron -    22484847 chr7:128402901(+) A-G intron -    22484847 chr7:128402902(+) A-G intron -    22484847 chr7:128402904(+) A-G intron -    22484847 chr7:128402906(+) A-G intron -    22484847 chr7:128402983(+) A-G intron -    22484847 chr7:128402998(+) A-G intron -    22484847 chr7:128403335(+) A-G intron -    22484847 chr7:128403407(+) A-G intron -    22484847 chr7:128403418(+) A-G intron -    22484847 chr7:128403421(+) A-G intron -    22484847 chr7:128403422(+) A-G intron -    22484847 chr7:128403423(+) A-G intron -    22484847 chr7:128403424(+) A-G intron -    22484847 chr7:128403425(+) A-G intron -    22484847 chr7:128403427(+) A-G intron -    22484847 chr7:128403464(+) A-G intron -    22484847 chr7:128404350(+) A-G intron -    22484847 chr7:128404372(+) A-G intron -    22484847 chr7:128404421(+) A-G intron -    22484847 chr7:128404432(+) A-G intron -    22484847 chr7:128404467(+) A-G intron -    22484847 chr7:128405007(+) A-G intron -    22484847 chr7:128405048(+) A-G intron -    22484847 chr7:128405306(+) A-G intron -    22484847 chr7:128405354(+) A-G intron -    22484847 chr7:128406064(+) A-G intron -    22484847 chr7:128406199(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CALU	chr7:128379391-128379392(+) m6A 5'UTR       24981863 chr7:128387907-128387908(+) m6A 5'UTR//intron       24981863//22608085 chr7:128387949-128387950(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr7:128387991-128387992(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr7:128388048-128388049(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr7:128388062-128388063(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr7:128388106-128388107(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388126-128388127(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388164-128388165(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388184-128388185(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388229-128388230(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr7:128388234-128388235(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr7:128388280-128388281(+) m6A 5'UTR//intron       24981863//22608085 chr7:128388311-128388312(+) m6A 5'UTR//intron       22608085 chr7:128388359-128388360(+) m6A 5'UTR//intron       22608085 chr7:128388370-128388371(+) m6A 5'UTR//intron       22608085 chr7:128388696-128388697(+) m6A CDS       27773535 chr7:128388713-128388714(+) m6A CDS       27773535 chr7:128388814-128388815(+) m6A CDS       24981863//26404942//27773535 chr7:128394377-128394378(+) m6A CDS//intron       24981863//26404942//27773535 chr7:128394427-128394428(+) Cm CDS//intron       - chr7:128394692-128394693(+) m6A CDS//intron       27773535 chr7:128398958-128398959(+) m6A CDS       24209618//24981863//26404942//27773535 chr7:128398999-128399000(+) m6A CDS       24209618//24981863//26404942//27773535 chr7:128399011-128399012(+) m6A CDS       24209618//24981863//26404942//27773535 chr7:128399848-128399849(+) m6A CDS       24209618//24981863//26404942//27773535//22575960 chr7:128407559-128407560(+) m6A CDS//intron       24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407596-128407597(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407607-128407608(+) Am CDS//intron       - chr7:128407614-128407615(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407625-128407626(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407632-128407633(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407650-128407651(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128407698-128407699(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128407704-128407705(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409232-128409233(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409303-128409304(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409316-128409317(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409326-128409327(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409347-128409348(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409382-128409383(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409409-128409410(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409544-128409545(+) m6A 3'UTR//intron       26404942//27773535 chr7:128409695-128409696(+) m6A 3'UTR//intron       27773535 chr7:128410044-128410045(+) Y 3'UTR//intron       25219674 chr7:128410416-128410417(+) m6A 3'UTR//intron       26404942//27773535 chr7:128410464-128410465(+) m6A 3'UTR//intron       26404942//27773535 chr7:128410520-128410521(+) Am 3'UTR//intron       - chr7:128410531-128410532(+) m6A 3'UTR//intron       26404942//27773535 chr7:128410560-128410561(+) m6A 3'UTR//intron       24981863//26404942//27773535 chr7:128410714-128410715(+) m6A 3'UTR//intron       27773535 chr7:128410763-128410764(+) m6A 3'UTR//intron       27773535 chr7:128411136-128411137(+) m6A 3'UTR//intron       27773535 chr7:128411191-128411192(+) m6A 3'UTR//intron       27773535 chr7:128411248-128411249(+) Y 3'UTR//intron       26075521 chr7:128411272-128411273(+) m6A 3'UTR//intron       26404942 chr7:128411288-128411289(+) m6A 3'UTR//intron       26404942 chr7:128411377-128411378(+) m6A 3'UTR//intron       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CALU	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-6-3p
Interactor2: CALU

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.