Basic Information:

  VIRBase ID:  

VHID00452757

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-5p:  MIMAT0002188          JCAD:  NM_001350001     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-6-5p	JCAD
miRBase Accession/Entrez ID	MIMAT0002188	57608
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAA1462

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	JCAD	chr10:30320164(-) A-I      intronic chr10:30319205(-) A-I      intronic chr10:30320153(-) A-I      intronic chr10:30319323(-) A-I      intronic chr10:30320355(-) A-I      intronic chr10:30320148(-) A-I      intronic chr10:30319218(-) A-I      intronic chr10:30319207(-) A-I      intronic chr10:30320184(-) A-I      intronic chr10:30309948(-) A-I      intronic chr10:30309947(-) A-I      intronic chr10:30310013(-) A-I      intronic chr10:30309988(-) A-I      intronic chr10:30309987(-) A-I      intronic chr10:30309974(-) A-I      intronic chr10:30320170(-) A-I      intronic chr10:30320273(-) A-I      intronic chr10:30312065(-) A-I      intronic chr10:30337601(-) A-I      intronic chr10:30312043(-) A-I      intronic chr10:30313753(-) A-I      intronic chr10:30313736(-) A-I      intronic chr10:30313011(-) A-I      intronic chr10:30313672(-) A-I      intronic chr10:30311972(-) A-I      intronic chr10:30312204(-) A-I      intronic chr10:30312105(-) A-I      intronic chr10:30337659(-) A-I      intronic chr10:30320848(-) A-I      intronic chr10:30319193(-) A-I      intronic chr10:30319190(-) A-I      intronic chr10:30320279(-) A-I      intronic chr10:30314723(-) A-I      intronic chr10:30314706(-) A-I      intronic chr10:30312104(-) A-I      intronic chr10:30312186(-) A-I      intronic chr10:30313896(-) A-I      intronic chr10:30313749(-) A-I      intronic chr10:30313748(-) A-I      intronic chr10:30313012(-) A-I      intronic chr10:30311988(-) A-I      intronic chr10:30339039(-) A-I      intronic chr10:30320225(-) A-I      intronic chr10:30320858(-) A-I      intronic chr10:30312034(-) A-I      intronic chr10:30319201(-) A-I      intronic chr10:30320118(-) A-I      intronic chr10:30320124(-) A-I      intronic chr10:30320194(-) A-I      intronic chr10:30306827(-) A-I      Syn:Arg->Arg chr10:30335964(-) A-I      intronic chr10:30319156(-) A-I      intronic chr10:30313821(-) A-I      intronic chr10:30308138(-) A-I      intronic chr10:30320228(-) A-I      intronic chr10:30314735(-) A-I      intronic chr10:30337778(-) A-I      intronic chr10:30314335(-) A-I      intronic chr10:30312972(-) A-I      intronic chr10:30313891(-) A-I      intronic chr10:30313897(-) A-I      intronic chr10:30314196(-) A-I      intronic chr10:30312063(-) A-I      intronic chr10:30339131(-) A-I      intronic chr10:30314683(-) A-I      intronic chr10:30320266(-) A-I      intronic chr10:30342928(-) A-I      intronic chr10:30312149(-) A-I      intronic chr10:30337610(-) A-I      intronic chr10:30319238(-) A-I      intronic chr10:30314303(-) A-I      intronic chr10:30314686(-) A-I      intronic chr10:30314190(-) A-I      intronic chr10:30342952(-) A-I      intronic chr10:30312160(-) A-I      intronic chr10:30312146(-) A-I      intronic chr10:30312982(-) A-I      intronic chr10:30312045(-) A-I      intronic chr10:30308115(-) A-I      intronic chr10:30313088(-) A-I      intronic chr10:30312185(-) A-I      intronic chr10:30323030(-) A-I      intronic chr10:30337669(-) A-I      intronic chr10:30337671(-) A-I      intronic chr10:30311105(-) A-I      intronic chr10:30309894(-) A-I      intronic chr10:30337666(-) A-I      intronic chr10:30320248(-) A-I      intronic chr10:30309969(-) A-I      intronic chr10:30311205(-) A-I      intronic chr10:30311199(-) A-I      intronic chr10:30309943(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	JCAD	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-6-5p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-6-5p
Interactor2: JCAD

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).