Basic Information:

  VIRBase ID:  

VHID00452554

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-5p:  MIMAT0002188          CDC37L1:  NM_017913     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-6-5p	CDC37L1
miRBase Accession/Entrez ID	MIMAT0002188	55664
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDC37B//HARC

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDC37L1	chr9:4693277(+) A-I      intronic chr9:4693403(+) A-I      intronic chr9:4694179(+) A-I      intronic chr9:4694183(+) A-I      intronic chr9:4694184(+) A-I      intronic chr9:4694314(+) A-I      intronic chr9:4694611(+) A-I      intronic chr9:4695284(+) A-I      intronic chr9:4695335(+) A-I      intronic chr9:4695510(+) A-I      intronic chr9:4695511(+) A-I      intronic chr9:4695749(+) A-I      intronic chr9:4695773(+) A-I      intronic chr9:4695958(+) A-I      intronic chr9:4695966(+) A-I      intronic chr9:4694763(+) A-I      intronic chr9:4681458(+) A-I      intronic chr9:4681459(+) A-I      intronic chr9:4681484(+) A-I      intronic chr9:4681529(+) A-I      intronic chr9:4681533(+) A-I      intronic chr9:4681606(+) A-I      intronic chr9:4682457(+) A-I      intronic chr9:4682526(+) A-I      intronic chr9:4682534(+) A-I      intronic chr9:4682564(+) A-I      intronic chr9:4682599(+) A-I      intronic chr9:4684119(+) A-I      intronic chr9:4684137(+) A-I      intronic chr9:4684163(+) A-I      intronic chr9:4684190(+) A-I      intronic chr9:4684270(+) A-I      intronic chr9:4687558(+) A-I      intronic chr9:4688067(+) A-I      intronic chr9:4688139(+) A-I      intronic chr9:4688180(+) A-I      intronic chr9:4688197(+) A-I      intronic chr9:4693205(+) A-I      intronic chr9:4693260(+) A-I      intronic chr9:4695285(+) A-I      intronic chr9:4695774(+) A-I      intronic chr9:4681575(+) A-I      intronic chr9:4694791(+) A-I      intronic chr9:4694343(+) A-I      intronic chr9:4688129(+) A-I      intronic chr9:4684031(+) A-I      intronic chr9:4695204(+) A-I      intronic chr9:4687605(+) A-I      intronic chr9:4695612(+) A-I      intronic chr9:4693204(+) A-I      intronic chr9:4695917(+) A-I      intronic chr9:4694102(+) A-I      intronic chr9:4687421(+) A-I      intronic chr9:4694300(+) A-I      intronic chr9:4687564(+) A-I      intronic chr9:4696466(+) A-I      intronic chr9:4694101(+) A-I      intronic chr9:4694790(+) A-I      intronic chr9:4695264(+) A-I      intronic chr9:4693240(+) A-I      intronic chr9:4695208(+) A-I      intronic chr9:4688117(+) A-I      intronic chr9:4694289(+) A-I      intronic chr9:4681568(+) A-I      intronic chr9:4695530(+) A-I      intronic chr9:4694785(+) A-I      intronic chr9:4696046(+) A-I      intronic chr9:4693222(+) A-I      intronic chr9:4695757(+) A-I      intronic chr9:4694751(+) A-I      intronic chr9:4694618(+) A-I      intronic chr9:4693363(+) A-I      intronic chr9:4687580(+) A-I      intronic chr9:4694159(+) A-I      intronic chr9:4687445(+) A-I      intronic chr9:4694340(+) A-I      intronic chr9:4695697(+) A-I      intronic chr9:4695759(+) A-I      intronic chr9:4694174(+) A-I      intronic chr9:4693385(+) A-I      intronic chr9:4682224(+) A-I      intronic chr9:4694180(+) A-I      intronic chr9:4687432(+) A-I      intronic chr9:4695855(+) A-I      intronic chr9:4693418(+) A-I      intronic chr9:4695586(+) A-I      intronic chr9:4688075(+) A-I      intronic chr9:4694173(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDC37L1	chr9:4702216(+) A-I intron -    21960545 chr9:4694149(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDC37L1	chr9:4679658-4679659(+) m6A 5'UTR       24981863 chr9:4679750-4679751(+) m6A 5'UTR//exon       24981863 chr9:4679765-4679766(+) m6A 5'UTR//exon       24981863 chr9:4679772-4679773(+) m6A CDS//exon       24981863 chr9:4679793-4679794(+) m6A CDS//exon       24981863 chr9:4684974-4684975(+) m6A CDS//exon       - chr9:4685035-4685036(+) m6A CDS//exon       24981863//27773535 chr9:4685049-4685050(+) m6A CDS//exon       24981863//27773535 chr9:4706059-4706060(+) m6A CDS       24284625//24981863//22608085 chr9:4706087-4706088(+) m6A CDS       24284625//24981863//22608085 chr9:4706101-4706102(+) m6A CDS       24284625//24981863//22608085 chr9:4706122-4706123(+) m6A 3'UTR       24284625//24981863//22608085 chr9:4706163-4706164(+) m6A 3'UTR       24284625//24981863//22608085 chr9:4706336-4706337(+) m6A 3'UTR       27773535 chr9:4706341-4706342(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CDC37L1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-6-5p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-6-5p
Interactor2: CDC37L1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).