Basic Information:

  VIRBase ID:  

VHID00451802

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-5p:  MIMAT0002188          GGA2:  NM_015044     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-6-5p	GGA2
miRBase Accession/Entrez ID	MIMAT0002188	23062
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	VEAR

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GGA2	chr16:23519600(-) A-I      intronic chr16:23519588(-) A-I      intronic chr16:23519582(-) A-I      intronic chr16:23519581(-) A-I      intronic chr16:23519554(-) A-I      intronic chr16:23519552(-) A-I      intronic chr16:23488537(-) A-I      intronic chr16:23488424(-) A-I      intronic chr16:23487151(-) A-I      intronic chr16:23487127(-) A-I      intronic chr16:23482247(-) A-I      intronic chr16:23482236(-) A-I      intronic chr16:23477215(-) A-I      3'UTR chr16:23477216(-) A-I      3'UTR chr16:23477240(-) A-I      3'UTR chr16:23518840(-) A-I      intronic chr16:23510542(-) A-I      intronic chr16:23518825(-) A-I      intronic chr16:23484307(-) A-I      intronic chr16:23518821(-) A-I      intronic chr16:23484297(-) A-I      intronic chr16:23482279(-) A-I      intronic chr16:23486583(-) A-I      intronic chr16:23484741(-) A-I      intronic chr16:23484786(-) A-I      intronic chr16:23484876(-) A-I      intronic chr16:23484900(-) A-I      intronic chr16:23484916(-) A-I      intronic chr16:23484938(-) A-I      intronic chr16:23485771(-) A-I      intronic chr16:23485790(-) A-I      intronic chr16:23485906(-) A-I      intronic chr16:23485924(-) A-I      intronic chr16:23486000(-) A-I      intronic chr16:23486659(-) A-I      intronic chr16:23486784(-) A-I      intronic chr16:23486979(-) A-I      intronic chr16:23487006(-) A-I      intronic chr16:23487007(-) A-I      intronic chr16:23487045(-) A-I      intronic chr16:23487062(-) A-I      intronic chr16:23487126(-) A-I      intronic chr16:23487247(-) A-I      intronic chr16:23488388(-) A-I      intronic chr16:23488446(-) A-I      intronic chr16:23488467(-) A-I      intronic chr16:23488523(-) A-I      intronic chr16:23488524(-) A-I      intronic chr16:23488830(-) A-I      intronic chr16:23488883(-) A-I      intronic chr16:23495107(-) A-I      intronic chr16:23495143(-) A-I      intronic chr16:23495165(-) A-I      intronic chr16:23495214(-) A-I      intronic chr16:23495232(-) A-I      intronic chr16:23495241(-) A-I      intronic chr16:23500763(-) A-I      intronic chr16:23500842(-) A-I      intronic chr16:23502516(-) A-I      intronic chr16:23506864(-) A-I      intronic chr16:23507419(-) A-I      intronic chr16:23510467(-) A-I      intronic chr16:23510563(-) A-I      intronic chr16:23510630(-) A-I      intronic chr16:23510655(-) A-I      intronic chr16:23510660(-) A-I      intronic chr16:23510737(-) A-I      intronic chr16:23515157(-) A-I      intronic chr16:23515254(-) A-I      intronic chr16:23515316(-) A-I      intronic chr16:23515376(-) A-I      intronic chr16:23518769(-) A-I      intronic chr16:23518873(-) A-I      intronic chr16:23518897(-) A-I      intronic chr16:23519419(-) A-I      intronic chr16:23519569(-) A-I      intronic chr16:23484182(-) A-I      intronic chr16:23479887(-) A-I      intronic chr16:23481858(-) A-I      intronic chr16:23481872(-) A-I      intronic chr16:23481873(-) A-I      intronic chr16:23481901(-) A-I      intronic chr16:23482219(-) A-I      intronic chr16:23482272(-) A-I      intronic chr16:23482276(-) A-I      intronic chr16:23482321(-) A-I      intronic chr16:23482324(-) A-I      intronic chr16:23482333(-) A-I      intronic chr16:23483099(-) A-I      intronic chr16:23483105(-) A-I      intronic chr16:23483145(-) A-I      intronic chr16:23483572(-) A-I      intronic chr16:23483612(-) A-I      intronic chr16:23483625(-) A-I      intronic chr16:23483647(-) A-I      intronic chr16:23483675(-) A-I      intronic chr16:23483679(-) A-I      intronic chr16:23483686(-) A-I      intronic chr16:23484245(-) A-I      intronic chr16:23484332(-) A-I      intronic chr16:23484344(-) A-I      intronic chr16:23484779(-) A-I      intronic chr16:23477162(-) A-I      3'UTR chr16:23475262(-) A-I      3'UTR chr16:23477210(-) A-I      3'UTR chr16:23475053(-) A-I      3'UTR chr16:23475226(-) A-I      3'UTR chr16:23477205(-) A-I      3'UTR chr16:23477040(-) A-I      3'UTR chr16:23477045(-) A-I      3'UTR chr16:23477099(-) A-I      3'UTR chr16:23477138(-) A-I      3'UTR chr16:23495429(-) A-I      intronic chr16:23488992(-) A-I      intronic chr16:23484242(-) A-I      intronic chr16:23507465(-) A-I      intronic chr16:23486608(-) A-I      intronic chr16:23483907(-) A-I      intronic chr16:23488545(-) A-I      intronic chr16:23519520(-) A-I      intronic chr16:23488335(-) A-I      intronic chr16:23483722(-) A-I      intronic chr16:23508130(-) A-I      intronic chr16:23484782(-) A-I      intronic chr16:23488486(-) A-I      intronic chr16:23507375(-) A-I      intronic chr16:23484921(-) A-I      intronic chr16:23482007(-) A-I      intronic chr16:23518905(-) A-I      intronic chr16:23519229(-) A-I      intronic chr16:23488437(-) A-I      intronic chr16:23511049(-) A-I      intronic chr16:23508131(-) A-I      intronic chr16:23487139(-) A-I      intronic chr16:23510744(-) A-I      intronic chr16:23519196(-) A-I      intronic chr16:23483791(-) A-I      intronic chr16:23519490(-) A-I      intronic chr16:23492537(-) A-I      intronic chr16:23508197(-) A-I      intronic chr16:23519452(-) A-I      intronic chr16:23484233(-) A-I      intronic chr16:23488397(-) A-I      intronic chr16:23486724(-) A-I      intronic chr16:23483184(-) A-I      intronic chr16:23483712(-) A-I      intronic chr16:23519659(-) A-I      intronic chr16:23487191(-) A-I      intronic chr16:23481940(-) A-I      intronic chr16:23486705(-) A-I      intronic chr16:23519580(-) A-I      intronic chr16:23486596(-) A-I      intronic chr16:23489506(-) A-I      intronic chr16:23486616(-) A-I      intronic chr16:23486704(-) A-I      intronic chr16:23488552(-) A-I      intronic chr16:23481962(-) A-I      intronic chr16:23519277(-) A-I      intronic chr16:23506842(-) A-I      intronic chr16:23509343(-) A-I      intronic chr16:23510562(-) A-I      intronic chr16:23476526(-) A-I      3'UTR chr16:23477180(-) A-I      3'UTR chr16:23476578(-) A-I      3'UTR chr16:23475078(-) A-I      3'UTR chr16:23477019(-) A-I      3'UTR chr16:23477179(-) A-I      3'UTR chr16:23475033(-) A-I      3'UTR chr16:23477057(-) A-I      3'UTR chr16:23477114(-) A-I      3'UTR chr16:23475282(-) A-I      3'UTR chr16:23475051(-) A-I      3'UTR chr16:23477260(-) A-I      3'UTR chr16:23519660(-) A-I      intronic chr16:23518783(-) A-I      intronic chr16:23507937(-) A-I      intronic chr16:23493554(-) A-I      intronic chr16:23509457(-) A-I      intronic chr16:23502349(-) A-I      intronic chr16:23488546(-) A-I      intronic chr16:23483111(-) A-I      intronic chr16:23519119(-) A-I      intronic chr16:23481921(-) A-I      intronic chr16:23518999(-) A-I      intronic chr16:23483792(-) A-I      intronic chr16:23495404(-) A-I      intronic chr16:23486587(-) A-I      intronic chr16:23502327(-) A-I      intronic chr16:23500694(-) A-I      intronic chr16:23484740(-) A-I      intronic chr16:23481918(-) A-I      intronic chr16:23519035(-) A-I      intronic chr16:23486797(-) A-I      intronic chr16:23518792(-) A-I      intronic chr16:23482002(-) A-I      intronic chr16:23484291(-) A-I      intronic chr16:23494571(-) A-I      intronic chr16:23488452(-) A-I      intronic chr16:23483946(-) A-I      intronic chr16:23484313(-) A-I      intronic chr16:23518827(-) A-I      intronic chr16:23519426(-) A-I      intronic chr16:23484211(-) A-I      intronic chr16:23519021(-) A-I      intronic chr16:23487237(-) A-I      intronic chr16:23495106(-) A-I      intronic chr16:23487210(-) A-I      intronic chr16:23484750(-) A-I      intronic chr16:23488349(-) A-I      intronic chr16:23487059(-) A-I      intronic chr16:23481866(-) A-I      intronic chr16:23483141(-) A-I      intronic chr16:23482315(-) A-I      intronic chr16:23507887(-) A-I      intronic chr16:23515140(-) A-I      intronic chr16:23510694(-) A-I      intronic chr16:23488370(-) A-I      intronic chr16:23519556(-) A-I      intronic chr16:23508322(-) A-I      intronic chr16:23487129(-) A-I      intronic chr16:23486619(-) A-I      intronic chr16:23488489(-) A-I      intronic chr16:23484809(-) A-I      intronic chr16:23483144(-) A-I      intronic chr16:23488433(-) A-I      intronic chr16:23495384(-) A-I      intronic chr16:23488944(-) A-I      intronic chr16:23502298(-) A-I      intronic chr16:23487168(-) A-I      intronic chr16:23519606(-) A-I      intronic chr16:23509449(-) A-I      intronic chr16:23479959(-) A-I      intronic chr16:23519555(-) A-I      intronic chr16:23488361(-) A-I      intronic chr16:23485878(-) A-I      intronic chr16:23519038(-) A-I      intronic chr16:23486792(-) A-I      intronic chr16:23506884(-) A-I      intronic chr16:23479618(-) A-I      intronic chr16:23482066(-) A-I      intronic chr16:23515240(-) A-I      intronic chr16:23506158(-) A-I      intronic chr16:23481827(-) A-I      intronic chr16:23515146(-) A-I      intronic chr16:23508179(-) A-I      intronic chr16:23510751(-) A-I      intronic chr16:23488875(-) A-I      intronic chr16:23488968(-) A-I      intronic chr16:23519034(-) A-I      intronic chr16:23500761(-) A-I      intronic chr16:23488362(-) A-I      intronic chr16:23481974(-) A-I      intronic chr16:23488469(-) A-I      intronic chr16:23487188(-) A-I      intronic chr16:23483643(-) A-I      intronic chr16:23507425(-) A-I      intronic chr16:23481927(-) A-I      intronic chr16:23519526(-) A-I      intronic chr16:23519566(-) A-I      intronic chr16:23519565(-) A-I      intronic chr16:23482064(-) A-I      intronic chr16:23502312(-) A-I      intronic chr16:23486783(-) A-I      intronic chr16:23483532(-) A-I      intronic chr16:23506868(-) A-I      intronic chr16:23502506(-) A-I      intronic chr16:23482319(-) A-I      intronic chr16:23482001(-) A-I      intronic chr16:23519278(-) A-I      intronic chr16:23519255(-) A-I      intronic chr16:23519267(-) A-I      intronic chr16:23487042(-) A-I      intronic chr16:23518866(-) A-I      intronic chr16:23508227(-) A-I      intronic chr16:23483115(-) A-I      intronic chr16:23484316(-) A-I      intronic chr16:23484715(-) A-I      intronic chr16:23481936(-) A-I      intronic chr16:23519557(-) A-I      intronic chr16:23506893(-) A-I      intronic chr16:23507970(-) A-I      intronic chr16:23509339(-) A-I      intronic chr16:23483713(-) A-I      intronic chr16:23500672(-) A-I      intronic chr16:23509645(-) A-I      intronic chr16:23518913(-) A-I      intronic chr16:23518757(-) A-I      intronic chr16:23486737(-) A-I      intronic chr16:23515290(-) A-I      intronic chr16:23510589(-) A-I      intronic chr16:23506817(-) A-I      intronic chr16:23518849(-) A-I      intronic chr16:23507909(-) A-I      intronic chr16:23483723(-) A-I      intronic chr16:23519451(-) A-I      intronic chr16:23495060(-) A-I      intronic chr16:23518863(-) A-I      intronic chr16:23482311(-) A-I      intronic chr16:23483230(-) A-I      intronic chr16:23515237(-) A-I      intronic chr16:23508193(-) A-I      intronic chr16:23509375(-) A-I      intronic chr16:23519039(-) A-I      intronic chr16:23485858(-) A-I      intronic chr16:23492443(-) A-I      intronic chr16:23519496(-) A-I      intronic chr16:23488419(-) A-I      intronic chr16:23515293(-) A-I      intronic chr16:23508192(-) A-I      intronic chr16:23486626(-) A-I      intronic chr16:23484166(-) A-I      intronic chr16:23488411(-) A-I      intronic chr16:23510649(-) A-I      intronic chr16:23488492(-) A-I      intronic chr16:23519525(-) A-I      intronic chr16:23508086(-) A-I      intronic chr16:23510738(-) A-I      intronic chr16:23508222(-) A-I      intronic chr16:23483969(-) A-I      intronic chr16:23488375(-) A-I      intronic chr16:23519516(-) A-I      intronic chr16:23488311(-) A-I      intronic chr16:23500789(-) A-I      intronic chr16:23502311(-) A-I      intronic chr16:23488455(-) A-I      intronic chr16:23510666(-) A-I      intronic chr16:23487175(-) A-I      intronic chr16:23506159(-) A-I      intronic chr16:23508106(-) A-I      intronic chr16:23477248(-) A-I      3'UTR chr16:23475060(-) A-I      3'UTR chr16:23475023(-) A-I      3'UTR chr16:23476635(-) A-I      3'UTR chr16:23475206(-) A-I      3'UTR chr16:23476579(-) A-I      3'UTR chr16:23475166(-) A-I      3'UTR chr16:23478496(-) A-I      3'UTR chr16:23476474(-) A-I      3'UTR chr16:23475075(-) A-I      3'UTR chr16:23475231(-) A-I      3'UTR chr16:23476510(-) A-I      3'UTR chr16:23475169(-) A-I      3'UTR chr16:23476595(-) A-I      3'UTR chr16:23476506(-) A-I      3'UTR chr16:23475102(-) A-I      3'UTR chr16:23476581(-) A-I      3'UTR chr16:23477005(-) A-I      3'UTR chr16:23477186(-) A-I      3'UTR chr16:23476649(-) A-I      3'UTR chr16:23476587(-) A-I      3'UTR chr16:23475176(-) A-I      3'UTR chr16:23475039(-) A-I      3'UTR chr16:23475052(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GGA2	chr16:23476474(-) A-I exon 3'UTR    19478186   //22327324 chr16:23476506(-) A-I exon 3'UTR    22327324 chr16:23477179(-) A-I exon 3'UTR    21960545   //22327324 chr16:23482064(-) A-I intron -    22327324 chr16:23477180(-) A-I exon 3'UTR    21960545 chr16:23477090(-) A-I exon 3'UTR    21960545 chr16:23476581(-) A-G exon 3'UTR    21725310   //22484847 chr16:23477087(-) A-G exon 3'UTR    21725310 chr16:23475039(-) A-G exon 3'UTR    22484847 chr16:23475282(-) A-G exon 3'UTR    22484847 chr16:23476506(-) A-G exon 3'UTR    22484847 chr16:23476526(-) A-G exon 3'UTR    22484847 chr16:23477179(-) A-G exon 3'UTR    22484847 chr16:23481866(-) A-G intron -    22484847 chr16:23481918(-) A-G intron -    22484847 chr16:23481921(-) A-G intron -    22484847 chr16:23482064(-) A-G intron -    22484847 chr16:23482311(-) A-G intron -    22484847 chr16:23482315(-) A-G intron -    22484847 chr16:23483111(-) A-G intron -    22484847 chr16:23483144(-) A-G intron -    22484847 chr16:23483184(-) A-G intron -    22484847 chr16:23484211(-) A-G intron -    22484847 chr16:23484242(-) A-G intron -    22484847 chr16:23484291(-) A-G intron -    22484847 chr16:23484313(-) A-G intron -    22484847 chr16:23488375(-) A-G intron -    22484847 chr16:23506868(-) A-G intron -    22484847 chr16:23511049(-) A-G intron -    22484847 chr16:23519426(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GGA2	chr16:23476014-23476015(-) m6A 3'UTR       27773535 chr16:23476067-23476068(-) m6A 3'UTR       27773535 chr16:23476120-23476121(-) Y 3'UTR       26075521 chr16:23477358-23477359(-) m6A 3'UTR//intron       27773535//22608085 chr16:23477366-23477367(-) m6A 3'UTR//intron       27773535//22608085 chr16:23477375-23477376(-) m6A 3'UTR//intron       27773535//22608085 chr16:23477417-23477418(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr16:23477521-23477522(-) m6A 3'UTR//intron       24284625//25456834//24981863//28052920//27773535//22608085 chr16:23477529-23477530(-) m6A 3'UTR//intron       24284625//25456834//24981863//28052920//27773535//22575960//22608085 chr16:23477557-23477558(-) m6A 3'UTR//intron       24284625//25456834//24981863//28052920//27773535//22575960//22608085 chr16:23477611-23477612(-) m6A 3'UTR//intron       24284625//25456834//24981863//28052920//27773535//22575960//22608085 chr16:23477665-23477666(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr16:23477744-23477745(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr16:23477768-23477769(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr16:23477813-23477814(-) m6A 3'UTR//intron       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr16:23477840-23477841(-) m6A 3'UTR//intron       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr16:23477986-23477987(-) m6A 3'UTR//exon//intron       24209618//24981863//28052920//27773535//22608085 chr16:23478002-23478003(-) m6A 3'UTR//exon//intron       24209618//24981863//28052920//27773535//22608085 chr16:23478225-23478226(-) m6A 3'UTR//exon//intron       24284625//24981863//22575960 chr16:23478268-23478269(-) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr16:23478282-23478283(-) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr16:23478290-23478291(-) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr16:23478372-23478373(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863 chr16:23478394-23478395(-) m6A 3'UTR//exon//intron       24209618//24981863 chr16:23478449-23478450(-) m6A 3'UTR//exon//intron       24209618//24981863 chr16:23478461-23478462(-) m6A 3'UTR//exon//intron       24209618 chr16:23478845-23478846(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr16:23478894-23478895(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr16:23478935-23478936(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr16:23478944-23478945(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr16:23478976-23478977(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr16:23479018-23479019(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr16:23489721-23489722(-) m6A CDS//exon//intron       27773535 chr16:23489736-23489737(-) m6A CDS//exon//intron       27773535 chr16:23489748-23489749(-) m6A CDS//exon//intron       27773535 chr16:23497470-23497471(-) m6A CDS//exon//intron       24284625//24981863//27773535//22575960 chr16:23498058-23498059(-) m6A CDS//exon//intron       24981863//27773535//22575960 chr16:23498073-23498074(-) m6A CDS//exon       24981863//27773535//22575960 chr16:23500007-23500008(-) m6A 3'UTR//CDS//exon       27773535 chr16:23500014-23500015(-) m6A 3'UTR//CDS//exon       27773535 chr16:23500019-23500020(-) m6A 3'UTR//CDS//exon       27773535 chr16:23503001-23503002(-) m6A 3'UTR//CDS//exon       27773535 chr16:23503038-23503039(-) m6A 3'UTR//CDS//exon       27773535 chr16:23503057-23503058(-) m6A 3'UTR//CDS//exon       27773535 chr16:23506692-23506693(-) m6A exon//intron       27773536 chr16:23506736-23506737(-) m6A exon//intron       - chr16:23507029-23507030(-) m6A 3'UTR//CDS//exon//intron       24209618//27371828//27773536 chr16:23507070-23507071(-) m6A CDS//exon       24209618//27371828//27773536 chr16:23507086-23507087(-) m6A CDS//exon       24209618//27371828//27773536 chr16:23521695-23521696(-) m6A CDS//exon//intron       24209618//24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GGA2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-6-5p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-6-5p
Interactor2: GGA2

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).