Basic Information:

  VIRBase ID:  

VHID00450384

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-5p:  MIMAT0002188          JAK2:  NR_169764     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-6-5p	JAK2
miRBase Accession/Entrez ID	MIMAT0002188	3717
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	JTK10

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	JAK2	chr9:5102325(+) A-I      intronic chr9:5025674(+) A-I      intronic chr9:5025678(+) A-I      intronic chr9:5064281(+) A-I      intronic chr9:5102353(+) A-I      intronic chr9:5102375(+) A-I      intronic chr9:5120073(+) A-I      intronic chr9:5102378(+) A-I      intronic chr9:5102381(+) A-I      intronic chr9:5102389(+) A-I      intronic chr9:5120051(+) A-I      intronic chr9:5120066(+) A-I      intronic chr9:5064291(+) A-I      intronic chr9:5120089(+) A-I      intronic chr9:5120098(+) A-I      intronic chr9:5025742(+) A-I      intronic chr9:5025663(+) A-I      intronic chr9:5025608(+) A-I      intronic chr9:5085751(+) A-I      intronic chr9:5085772(+) A-I      intronic chr9:5085787(+) A-I      intronic chr9:5085806(+) A-I      intronic chr9:5112688(+) A-I      intronic chr9:5112689(+) A-I      intronic chr9:5112702(+) A-I      intronic chr9:5102318(+) A-I      intronic chr9:5102317(+) A-I      intronic chr9:5102328(+) A-I      intronic chr9:5102336(+) A-I      intronic chr9:5102351(+) A-I      intronic chr9:5112730(+) A-I      intronic chr9:5102331(+) A-I      intronic chr9:5025672(+) A-I      intronic chr9:4996305(+) A-I      intronic chr9:4996359(+) A-I      intronic chr9:4996380(+) A-I      intronic chr9:5021767(+) A-I      intronic chr9:5025627(+) A-I      intronic chr9:5102383(+) A-I      intronic chr9:5005212(+) A-I      intronic chr9:4996298(+) A-I      intronic chr9:4997041(+) A-I      intronic chr9:5042150(+) A-I      intronic chr9:5021764(+) A-I      intronic chr9:5021758(+) A-I      intronic chr9:5005188(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	JAK2	chr9:4985095-4985096(+) m6A exon       24981863 chr9:5090814-5090815(+) m6A CDS       24981863 chr9:5090862-5090863(+) m6A CDS       24981863 chr9:5111064-5111065(+) m6A intron       - chr9:5111103-5111104(+) m6A intron       - chr9:5114531-5114532(+) m6A intron       - chr9:5114537-5114538(+) m6A intron       - chr9:5114567-5114568(+) m6A intron       - chr9:5114582-5114583(+) m6A intron       - chr9:5126813-5126814(+) m6A 3'UTR//exon       24981863 chr9:5126832-5126833(+) m6A 3'UTR//exon       24981863 chr9:5126861-5126862(+) m6A 3'UTR//exon       24981863//22608085 chr9:5126934-5126935(+) m6A 3'UTR//exon       24981863//22608085 chr9:5126981-5126982(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	JAK2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	kshv-miR-K12-6-5p	l-685,458       5479543

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-6-5p
Interactor2: JAK2

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).