Detail Information

Basic Information:


  VIRBase ID:  

VHID00450371

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-6-5p:           IRS1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-6-5p IRS1
miRBase
Accession/Entrez ID		 MIMAT0002188 3667
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - HIRS-1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IRS1
chr2:227630995(-) A-I      intronic
chr2:227650802(-) A-I      intronic
chr2:227631004(-) A-I      intronic
chr2:227630996(-) A-I      intronic
chr2:227631047(-) A-I      intronic
chr2:227650207(-) A-I      intronic
chr2:227631018(-) A-I      intronic
chr2:227630977(-) A-I      intronic
chr2:227631039(-) A-I      intronic
chr2:227649430(-) A-I      intronic
chr2:227649318(-) A-I      intronic
chr2:227649287(-) A-I      intronic
chr2:227631160(-) A-I      intronic
chr2:227631126(-) A-I      intronic
chr2:227631125(-) A-I      intronic
chr2:227631112(-) A-I      intronic
chr2:227631017(-) A-I      intronic
chr2:227630976(-) A-I      intronic
chr2:227630947(-) A-I      intronic
chr2:227629901(-) A-I      intronic
chr2:227649271(-) A-I      intronic
chr2:227650317(-) A-I      intronic
chr2:227650139(-) A-I      intronic
chr2:227650084(-) A-I      intronic
chr2:227650062(-) A-I      intronic
chr2:227650053(-) A-I      intronic
chr2:227649333(-) A-I      intronic
chr2:227650225(-) A-I      intronic
chr2:227650197(-) A-I      intronic
chr2:227649166(-) A-I      intronic
chr2:227649411(-) A-I      intronic
chr2:227649412(-) A-I      intronic
chr2:227649321(-) A-I      intronic
chr2:227649332(-) A-I      intronic
chr2:227649235(-) A-I      intronic
chr2:227631058(-) A-I      intronic
chr2:227630988(-) A-I      intronic
chr2:227611634(-) A-I      intronic
chr2:227649224(-) A-I      intronic
chr2:227650315(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IRS1
chr2:227600394-227600395(-) m6A 3'UTR       27773535
chr2:227600560-227600561(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535
chr2:227600602-227600603(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr2:227600702-227600703(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr2:227600723-227600724(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr2:227600795-227600796(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr2:227600882-227600883(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr2:227600912-227600913(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr2:227600958-227600959(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535
chr2:227656939-227656940(-) m6A exon//intron       24284625//24981863//27773535
chr2:227656945-227656946(-) m6A exon//intron       24284625//24981863//27773535
chr2:227656961-227656962(-) m6A exon//intron       27773535
chr2:227657021-227657022(-) m6A exon//intron       24284625//24981863
chr2:227659715-227659716(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr2:227659735-227659736(-) m6A CDS//exon       24284625//24209618//24981863//27773535
chr2:227659860-227659861(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227659887-227659888(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227659894-227659895(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227659912-227659913(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227659959-227659960(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227660147-227660148(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227660182-227660183(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227660227-227660228(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr2:227660259-227660260(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr2:227660405-227660406(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr2:227660446-227660447(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227660562-227660563(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr2:227660620-227660621(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr2:227660648-227660649(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227660903-227660904(-) m6A CDS       24284625//24209618//24981863//26404942//22575960
chr2:227660917-227660918(-) m6A CDS       24284625//24209618//24981863//26404942//22575960
chr2:227661190-227661191(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535
chr2:227661235-227661236(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr2:227661253-227661254(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr2:227661309-227661310(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227661356-227661357(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227661377-227661378(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227661481-227661482(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227661562-227661563(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227661649-227661650(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:227661744-227661745(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr2:227661839-227661840(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085
chr2:227661881-227661882(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085
chr2:227661962-227661963(-) m6A CDS       24284625//24981863//27773535//22575960
chr2:227662394-227662395(-) m6A CDS       24284625
chr2:227662700-227662701(-) m6A CDS       24284625//24209618//25456834//27773535//22575960
chr2:227662711-227662712(-) m6A CDS       24284625//24209618//25456834//27773535//22575960
chr2:227662798-227662799(-) m6A CDS       24284625//24209618//25456834//24981863
chr2:227662825-227662826(-) m6A CDS       24284625//24209618//25456834//24981863
chr2:227662861-227662862(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr2:227662883-227662884(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr2:227662921-227662922(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr2:227662928-227662929(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr2:227662983-227662984(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr2:227663011-227663012(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr2:227663143-227663144(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:227663161-227663162(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:227663215-227663216(-) m6A CDS       24284625//24209618//24981863//27773535//27371828
chr2:227663391-227663392(-) m6A CDS       24284625
chr2:227663664-227663665(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr2:227663739-227663740(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr2:227663805-227663806(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr2:227663833-227663834(-) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr2:227663886-227663887(-) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227663956-227663957(-) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227663974-227663975(-) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227664306-227664307(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536
chr2:227664317-227664318(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536
chr2:227664334-227664335(-) m6A 5'UTR       24284625//25456834//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate IRS1
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug kshv-miR-K12-6-5p
l-685,458       5479543

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-6-5p
Interactor2: IRS1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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