Basic Information:

  VIRBase ID:  

VHID00449646

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-7-3p:  MIMAT0002187          MTX3:  NM_001363818     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-7-3p	MTX3
miRBase Accession/Entrez ID	MIMAT0002187	345778
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MTX3	chr5:79283767(-) A-I      intronic chr5:79283777(-) A-I      intronic chr5:79283833(-) A-I      intronic chr5:79283859(-) A-I      intronic chr5:79283882(-) A-I      intronic chr5:79280979(-) A-I      intronic chr5:79281076(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MTX3	chr5:79281864(-) A-I intron -    15342557 chr5:79281890(-) A-I intron -    15342557 chr5:79283015(-) A-I intron -    15342557 chr5:79283047(-) A-I intron -    15342557 chr5:79283084(-) A-I intron -    15342557 chr5:79283098(-) A-I intron -    15342557 chr5:79283101(-) A-I intron -    15342557 chr5:79283151(-) A-I intron -    15342557 chr5:79283154(-) A-I intron -    15342557 chr5:79283047(-) A-G intron -    22484847 chr5:79283101(-) A-G intron -    22484847 chr5:79283919(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MTX3	chr5:79275944-79275945(-) Y 3'UTR       26075521 chr5:79276299-79276300(-) m6A 3'UTR       27773535 chr5:79276334-79276335(-) m6A 3'UTR       27773535 chr5:79276360-79276361(-) m6A 3'UTR       27773535 chr5:79279242-79279243(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr5:79279265-79279266(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr5:79279292-79279293(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr5:79279385-79279386(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr5:79279395-79279396(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr5:79279402-79279403(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr5:79279572-79279573(-) m6A 3'UTR//CDS//intron       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	MTX3	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-7-3p
Interactor2: MTX3

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).