Basic Information:

  VIRBase ID:  

VHID00449376

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-7-3p:  MIMAT0002187          SRXN1:  NM_080725     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-7-3p	SRXN1
miRBase Accession/Entrez ID	MIMAT0002187	140809
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf139//Npn3//SRX//SRX1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SRXN1	chr20:627338-627339(-) m6A 3'UTR       24209618//24981863//26404942//22608085 chr20:627478-627479(-) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:627483-627484(-) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:627489-627490(-) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:627607-627608(-) m6A 3'UTR       24284625//26404942//27773535 chr20:627659-627660(-) m6A 3'UTR       26404942//27773535 chr20:627700-627701(-) m6A 3'UTR       26404942 chr20:627724-627725(-) m6A 3'UTR       26404942 chr20:627747-627748(-) m6A 3'UTR       26404942 chr20:627808-627809(-) m6A 3'UTR       24284625//26404942 chr20:627878-627879(-) m6A 3'UTR       24284625//26404942 chr20:628016-628017(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628042-628043(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628115-628116(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628121-628122(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628127-628128(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628150-628151(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628435-628436(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr20:628450-628451(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr20:628461-628462(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628527-628528(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628553-628554(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628577-628578(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628600-628601(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628610-628611(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628621-628622(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628717-628718(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628744-628745(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628753-628754(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:628967-628968(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr20:628988-628989(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr20:629015-629016(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:629059-629060(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr20:629109-629110(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr20:629196-629197(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr20:629314-629315(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr20:629367-629368(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:629400-629401(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:629437-629438(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr20:629550-629551(-) m6A CDS       24284625//24209618//27773535//27371828//27773536//22575960 chr20:629556-629557(-) m6A CDS       24284625//24209618//27773535//27371828//27773536//22575960 chr20:633629-633630(-) m6A CDS       24284625//24209618//27773535//27773536//22575960 chr20:633656-633657(-) m6A CDS       24284625//24209618//27773535//27773536//22575960 chr20:633958-633959(-) m6A 5'UTR       24981863//27773536 chr20:633977-633978(-) m6A 5'UTR       24981863//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	SRXN1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-7-3p
Interactor2: SRXN1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.