Basic Information:

  VIRBase ID:  

VHID00449168

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-7-3p:  MIMAT0002187          NAV1:  NM_001389611     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-7-3p	NAV1
miRBase Accession/Entrez ID	MIMAT0002187	89796
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	POMFIL3//STEERIN1//UNC53H1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NAV1	chr1:201770083(+) A-I      intronic chr1:201770078(+) A-I      intronic chr1:201770021(+) A-I      intronic chr1:201768868(+) A-I      intronic chr1:201768867(+) A-I      intronic chr1:201768823(+) A-I      intronic chr1:201768812(+) A-I      intronic chr1:201768811(+) A-I      intronic chr1:201768804(+) A-I      intronic chr1:201737291(+) A-I      intronic chr1:201770134(+) A-I      intronic chr1:201770140(+) A-I      intronic chr1:201771494(+) A-I      intronic chr1:201771510(+) A-I      intronic chr1:201771523(+) A-I      intronic chr1:201771535(+) A-I      intronic chr1:201771548(+) A-I      intronic chr1:201771570(+) A-I      intronic chr1:201771571(+) A-I      intronic chr1:201771797(+) A-I      intronic chr1:201774850(+) A-I      intronic chr1:201770086(+) A-I      intronic chr1:201774855(+) A-I      intronic chr1:201774886(+) A-I      intronic chr1:201701338(+) A-I      intronic chr1:201774901(+) A-I      intronic chr1:201774918(+) A-I      intronic chr1:201774936(+) A-I      intronic chr1:201775009(+) A-I      intronic chr1:201785849(+) A-I      intronic chr1:201785883(+) A-I      intronic chr1:201785907(+) A-I      intronic chr1:201785915(+) A-I      intronic chr1:201785916(+) A-I      intronic chr1:201785919(+) A-I      intronic chr1:201737288(+) A-I      intronic chr1:201737277(+) A-I      intronic chr1:201737267(+) A-I      intronic chr1:201731099(+) A-I      intronic chr1:201597146(+) A-I      intronic chr1:201731097(+) A-I      intronic chr1:201731080(+) A-I      intronic chr1:201731079(+) A-I      intronic chr1:201731071(+) A-I      intronic chr1:201731066(+) A-I      intronic chr1:201596421(+) A-I      intronic chr1:201697883(+) A-I      intronic chr1:201646893(+) A-I      intronic chr1:201646885(+) A-I      intronic chr1:201768802(+) A-I      intronic chr1:201737300(+) A-I      intronic chr1:201646882(+) A-I      intronic chr1:201737297(+) A-I      intronic chr1:201737295(+) A-I      intronic chr1:201646873(+) A-I      intronic chr1:201646868(+) A-I      intronic chr1:201646862(+) A-I      intronic chr1:201737292(+) A-I      intronic chr1:201771529(+) A-I      intronic chr1:201774890(+) A-I      intronic chr1:201775168(+) A-I      intronic chr1:201775156(+) A-I      intronic chr1:201775006(+) A-I      intronic chr1:201774999(+) A-I      intronic chr1:201774970(+) A-I      intronic chr1:201774964(+) A-I      intronic chr1:201774940(+) A-I      intronic chr1:201774892(+) A-I      intronic chr1:201774873(+) A-I      intronic chr1:201787416(+) A-I      intronic chr1:201774779(+) A-I      intronic chr1:201774777(+) A-I      intronic chr1:201771895(+) A-I      intronic chr1:201697862(+) A-I      intronic chr1:201697867(+) A-I      intronic chr1:201698495(+) A-I      intronic chr1:201698690(+) A-I      intronic chr1:201698913(+) A-I      intronic chr1:201698940(+) A-I      intronic chr1:201698955(+) A-I      intronic chr1:201787423(+) A-I      intronic chr1:201701472(+) A-I      intronic chr1:201701527(+) A-I      intronic chr1:201702079(+) A-I      intronic chr1:201702119(+) A-I      intronic chr1:201702253(+) A-I      intronic chr1:201702254(+) A-I      intronic chr1:201702276(+) A-I      intronic chr1:201731090(+) A-I      intronic chr1:201731167(+) A-I      intronic chr1:201731177(+) A-I      intronic chr1:201731181(+) A-I      intronic chr1:201731185(+) A-I      intronic chr1:201731230(+) A-I      intronic chr1:201731262(+) A-I      intronic chr1:201734587(+) A-I      intronic chr1:201734592(+) A-I      intronic chr1:201734603(+) A-I      intronic chr1:201734626(+) A-I      intronic chr1:201734775(+) A-I      intronic chr1:201734785(+) A-I      intronic chr1:201734805(+) A-I      intronic chr1:201736006(+) A-I      intronic chr1:201736020(+) A-I      intronic chr1:201736031(+) A-I      intronic chr1:201736050(+) A-I      intronic chr1:201736067(+) A-I      intronic chr1:201736209(+) A-I      intronic chr1:201736318(+) A-I      intronic chr1:201736327(+) A-I      intronic chr1:201737243(+) A-I      intronic chr1:201737363(+) A-I      intronic chr1:201741907(+) A-I      intronic chr1:201742362(+) A-I      intronic chr1:201742366(+) A-I      intronic chr1:201742374(+) A-I      intronic chr1:201745062(+) A-I      intronic chr1:201767931(+) A-I      intronic chr1:201767935(+) A-I      intronic chr1:201768011(+) A-I      intronic chr1:201768014(+) A-I      intronic chr1:201768028(+) A-I      intronic chr1:201768031(+) A-I      intronic chr1:201768052(+) A-I      intronic chr1:201768710(+) A-I      intronic chr1:201768730(+) A-I      intronic chr1:201768732(+) A-I      intronic chr1:201771654(+) A-I      intronic chr1:201768764(+) A-I      intronic chr1:201768778(+) A-I      intronic chr1:201768786(+) A-I      intronic chr1:201768826(+) A-I      intronic chr1:201768827(+) A-I      intronic chr1:201768836(+) A-I      intronic chr1:201768881(+) A-I      intronic chr1:201768894(+) A-I      intronic chr1:201768951(+) A-I      intronic chr1:201768953(+) A-I      intronic chr1:201784971(+) A-I      intronic chr1:201769147(+) A-I      intronic chr1:201769181(+) A-I      intronic chr1:201769183(+) A-I      intronic chr1:201769192(+) A-I      intronic chr1:201769197(+) A-I      intronic chr1:201769207(+) A-I      intronic chr1:201769240(+) A-I      intronic chr1:201769257(+) A-I      intronic chr1:201769267(+) A-I      intronic chr1:201769349(+) A-I      intronic chr1:201769350(+) A-I      intronic chr1:201769363(+) A-I      intronic chr1:201769364(+) A-I      intronic chr1:201769367(+) A-I      intronic chr1:201769368(+) A-I      intronic chr1:201770008(+) A-I      intronic chr1:201770020(+) A-I      intronic chr1:201770026(+) A-I      intronic chr1:201770034(+) A-I      intronic chr1:201770037(+) A-I      intronic chr1:201770043(+) A-I      intronic chr1:201770061(+) A-I      intronic chr1:201770096(+) A-I      intronic chr1:201770112(+) A-I      intronic chr1:201770114(+) A-I      intronic chr1:201770118(+) A-I      intronic chr1:201770122(+) A-I      intronic chr1:201770123(+) A-I      intronic chr1:201770154(+) A-I      intronic chr1:201770157(+) A-I      intronic chr1:201770166(+) A-I      intronic chr1:201770218(+) A-I      intronic chr1:201770646(+) A-I      intronic chr1:201770670(+) A-I      intronic chr1:201770671(+) A-I      intronic chr1:201770683(+) A-I      intronic chr1:201770684(+) A-I      intronic chr1:201770723(+) A-I      intronic chr1:201770995(+) A-I      intronic chr1:201771000(+) A-I      intronic chr1:201771035(+) A-I      intronic chr1:201771044(+) A-I      intronic chr1:201771065(+) A-I      intronic chr1:201771128(+) A-I      intronic chr1:201771144(+) A-I      intronic chr1:201771154(+) A-I      intronic chr1:201771171(+) A-I      intronic chr1:201771302(+) A-I      intronic chr1:201771312(+) A-I      intronic chr1:201771339(+) A-I      intronic chr1:201771374(+) A-I      intronic chr1:201771382(+) A-I      intronic chr1:201771383(+) A-I      intronic chr1:201771475(+) A-I      intronic chr1:201768092(+) A-I      intronic chr1:201771491(+) A-I      intronic chr1:201771493(+) A-I      intronic chr1:201771511(+) A-I      intronic chr1:201771520(+) A-I      intronic chr1:201771521(+) A-I      intronic chr1:201771547(+) A-I      intronic chr1:201771653(+) A-I      intronic chr1:201771721(+) A-I      intronic chr1:201771723(+) A-I      intronic chr1:201771787(+) A-I      intronic chr1:201771788(+) A-I      intronic chr1:201771814(+) A-I      intronic chr1:201771849(+) A-I      intronic chr1:201771862(+) A-I      intronic chr1:201771864(+) A-I      intronic chr1:201771894(+) A-I      intronic chr1:201787277(+) A-I      intronic chr1:201785314(+) A-I      intronic chr1:201785310(+) A-I      intronic chr1:201785006(+) A-I      intronic chr1:201784996(+) A-I      intronic chr1:201784897(+) A-I      intronic chr1:201784479(+) A-I      intronic chr1:201784468(+) A-I      intronic chr1:201784079(+) A-I      intronic chr1:201596350(+) A-I      intronic chr1:201650945(+) A-I      intronic chr1:201671506(+) A-I      intronic chr1:201678260(+) A-I      intronic chr1:201692121(+) A-I      intronic chr1:201692145(+) A-I      intronic chr1:201692151(+) A-I      intronic chr1:201784076(+) A-I      intronic chr1:201697271(+) A-I      intronic chr1:201697273(+) A-I      intronic chr1:201783956(+) A-I      intronic chr1:201775347(+) A-I      intronic chr1:201775327(+) A-I      intronic chr1:201697343(+) A-I      intronic chr1:201775322(+) A-I      intronic chr1:201775313(+) A-I      intronic chr1:201697367(+) A-I      intronic chr1:201775296(+) A-I      intronic chr1:201697379(+) A-I      intronic chr1:201697389(+) A-I      intronic chr1:201775293(+) A-I      intronic chr1:201697778(+) A-I      intronic chr1:201697798(+) A-I      intronic chr1:201697855(+) A-I      intronic chr1:201697861(+) A-I      intronic chr1:201775275(+) A-I      intronic chr1:201775242(+) A-I      intronic chr1:201775213(+) A-I      intronic chr1:201597044(+) A-I      intronic chr1:201646329(+) A-I      intronic chr1:201650852(+) A-I      intronic chr1:201650855(+) A-I      intronic chr1:201769343(+) A-I      intronic chr1:201702387(+) A-I      intronic chr1:201597052(+) A-I      intronic chr1:201650987(+) A-I      intronic chr1:201702414(+) A-I      intronic chr1:201627040(+) A-I      intronic chr1:201597014(+) A-I      intronic chr1:201652578(+) A-I      intronic chr1:201647019(+) A-I      intronic chr1:201601618(+) A-I      intronic chr1:201596566(+) A-I      intronic chr1:201654244(+) A-I      intronic chr1:201652589(+) A-I      intronic chr1:201702428(+) A-I      intronic chr1:201646889(+) A-I      intronic chr1:201646233(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NAV1	chr1:201702387(+) A-I intron -    15258596 chr1:201702414(+) A-I intron -    15258596 chr1:201702428(+) A-I intron -    15258596 chr1:201764945(+) A-I intron -    15258596 chr1:201764953(+) A-I intron -    15258596 chr1:201764975(+) A-I intron -    15258596 chr1:201765001(+) A-I intron -    15258596 chr1:201767492(+) A-I intron -    15258596

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NAV1	chr1:201592093-201592094(+) m6A 5'UTR//CDS       - chr1:201592182-201592183(+) m6A 5'UTR//CDS       - chr1:201592211-201592212(+) m6A 5'UTR//CDS       24981863 chr1:201592324-201592325(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863 chr1:201592380-201592381(+) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863 chr1:201592420-201592421(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863 chr1:201592435-201592436(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863 chr1:201592477-201592478(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863 chr1:201592532-201592533(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863 chr1:201592547-201592548(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863 chr1:201592564-201592565(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863 chr1:201598538-201598539(+) m6A 5'UTR//exon       - chr1:201598549-201598550(+) m6A 5'UTR//exon       - chr1:201617382-201617383(+) m6A 5'UTR//intron       24981863 chr1:201617417-201617418(+) m6A 5'UTR//intron       24981863 chr1:201617873-201617874(+) m6A CDS       24209618//24981863 chr1:201618013-201618014(+) m6A CDS       24284625//24209618//25456834//24981863 chr1:201618091-201618092(+) m6A CDS       24284625//25456834//24981863//22608085 chr1:201618270-201618271(+) m6A CDS       - chr1:201618326-201618327(+) m6A CDS       24284625 chr1:201618490-201618491(+) m6A CDS       - chr1:201708494-201708495(+) m6A exon//intron       - chr1:201708524-201708525(+) m6A exon//intron       - chr1:201750222-201750223(+) m6A CDS//exon       25456834//24981863 chr1:201750255-201750256(+) m6A CDS//exon       25456834//24981863 chr1:201750262-201750263(+) m6A CDS//exon       25456834//24981863 chr1:201750321-201750322(+) m6A CDS//exon       24284625//25456834//24981863 chr1:201750364-201750365(+) m1A CDS//exon       26863410 chr1:201750373-201750374(+) m6A CDS//exon       24284625//25456834//24981863 chr1:201751307-201751308(+) m6A CDS//exon       24284625 chr1:201751327-201751328(+) m6A CDS//exon       24284625 chr1:201751390-201751391(+) m6A CDS//exon       24284625 chr1:201751503-201751504(+) m6A CDS//exon       24284625 chr1:201751578-201751579(+) m6A CDS//exon       24284625 chr1:201751709-201751710(+) m6A CDS//exon       24284625//24981863//22575960 chr1:201751781-201751782(+) m6A CDS//exon       24284625//25456834//24981863//22575960 chr1:201751815-201751816(+) m6A CDS//exon       24284625//25456834//24981863//22575960 chr1:201751839-201751840(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr1:201751885-201751886(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr1:201751891-201751892(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960 chr1:201751939-201751940(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960 chr1:201752557-201752558(+) m6A CDS//exon       24284625//24209618//25456834//24981863 chr1:201752789-201752790(+) m6A CDS//exon       24284625//24209618//25456834//24981863 chr1:201752806-201752807(+) m6A CDS//exon       24284625//24209618//25456834//24981863 chr1:201777196-201777197(+) m6A CDS       24981863 chr1:201777218-201777219(+) m6A CDS       24981863 chr1:201786294-201786295(+) m6A CDS       - chr1:201786368-201786369(+) m6A CDS       - chr1:201786378-201786379(+) m6A CDS       - chr1:201786399-201786400(+) m6A CDS       - chr1:201788981-201788982(+) m6A CDS       24209618 chr1:201789024-201789025(+) m6A CDS       24284625//24209618 chr1:201789034-201789035(+) m6A CDS       24284625//24209618//24981863//22608085 chr1:201789087-201789088(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr1:201789173-201789174(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:201789204-201789205(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:201789232-201789233(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:201789268-201789269(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:201789283-201789284(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:201789364-201789365(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:201789396-201789397(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr1:201789404-201789405(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr1:201789451-201789452(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr1:201789507-201789508(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr1:201789630-201789631(+) m6A 3'UTR       24284625//24981863//22608085 chr1:201789636-201789637(+) m6A 3'UTR       24284625//24981863//22608085 chr1:201789644-201789645(+) m6A 3'UTR       24284625//24981863//22608085 chr1:201789655-201789656(+) m6A 3'UTR       24284625//24981863//22608085 chr1:201789687-201789688(+) m6A 3'UTR       24284625//24981863//22608085 chr1:201789741-201789742(+) m6A 3'UTR       24284625//24981863//22608085 chr1:201789779-201789780(+) m6A 3'UTR       24981863//22608085 chr1:201789813-201789814(+) m6A 3'UTR       24981863 chr1:201790282-201790283(+) m6A 3'UTR       24284625//24981863 chr1:201790293-201790294(+) m6A 3'UTR       24284625//24981863 chr1:201790301-201790302(+) m6A 3'UTR       24284625//24981863 chr1:201790308-201790309(+) m6A 3'UTR       24284625//24981863 chr1:201790434-201790435(+) m6A 3'UTR       24284625//24981863 chr1:201790469-201790470(+) m6A 3'UTR       24981863 chr1:201790682-201790683(+) m6A 3'UTR       24981863 chr1:201790754-201790755(+) m6A 3'UTR       24284625//24981863 chr1:201790786-201790787(+) m6A 3'UTR       24284625//24981863 chr1:201790878-201790879(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr1:201790944-201790945(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr1:201790987-201790988(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:201791059-201791060(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr1:201791240-201791241(+) m6A 3'UTR       24981863//22608085 chr1:201791432-201791433(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr1:201791469-201791470(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr1:201791506-201791507(+) m6A 3'UTR       24284625//24981863 chr1:201791623-201791624(+) m6A 3'UTR       24284625//24981863 chr1:201791896-201791897(+) m6A 3'UTR       24209618//24981863//22608085 chr1:201792019-201792020(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr1:201792031-201792032(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr1:201792049-201792050(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr1:201792139-201792140(+) m6A 3'UTR       24284625//24981863//22608085 chr1:201792164-201792165(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	NAV1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-7-3p
Interactor2: NAV1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).