Detail Information

Basic Information:


  VIRBase ID:  

VHID00449013

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-7-3p:           ZNF436:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-7-3p ZNF436
miRBase
Accession/Entrez ID		 MIMAT0002187 80818
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - Zfp46//ZNF

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF436
chr1:23689920(-) A-I      intronic
chr1:23690440(-) A-I      intronic
chr1:23689906(-) A-I      intronic
chr1:23690868(-) A-I      intronic
chr1:23690851(-) A-I      intronic
chr1:23690842(-) A-I      intronic
chr1:23690453(-) A-I      intronic
chr1:23690276(-) A-I      intronic
chr1:23689981(-) A-I      intronic
chr1:23691026(-) A-I      intronic
chr1:23690348(-) A-I      intronic
chr1:23690473(-) A-I      intronic
chr1:23690413(-) A-I      intronic
chr1:23690423(-) A-I      intronic
chr1:23690315(-) A-I      intronic
chr1:23689946(-) A-I      intronic
chr1:23690452(-) A-I      intronic
chr1:23692316(-) A-I      intronic
chr1:23690288(-) A-I      intronic
chr1:23690316(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF436
chr1:23687652-23687653(-) m6A 3'UTR       27773535
chr1:23687781-23687782(-) m6A 3'UTR       24981863//27773535//22608085
chr1:23687788-23687789(-) m6A 3'UTR       24981863//27773535//22608085
chr1:23687802-23687803(-) m6A 3'UTR       24981863//27773535//22608085
chr1:23688049-23688050(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23688095-23688096(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23688117-23688118(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23688195-23688196(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23688203-23688204(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23688339-23688340(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr1:23688386-23688387(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr1:23688465-23688466(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr1:23688485-23688486(-) m6A CDS       24981863//27773535//22608085
chr1:23688542-23688543(-) m6A CDS       27773535//27371828//22608085
chr1:23688643-23688644(-) m6A CDS       27773535//27371828
chr1:23688653-23688654(-) m6A CDS       27773535//27371828
chr1:23688811-23688812(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr1:23688921-23688922(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr1:23688989-23688990(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr1:23689046-23689047(-) m6A CDS       24981863//27773535//27371828//22608085
chr1:23689063-23689064(-) m6A CDS       24981863//27773535//27371828//22608085
chr1:23689130-23689131(-) m6A CDS       24981863//27773535//27371828//22608085
chr1:23689147-23689148(-) m6A CDS       24981863//27773535//27371828//22608085
chr1:23689234-23689235(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23689315-23689316(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:23689386-23689387(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085
chr1:23689399-23689400(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085
chr1:23689419-23689420(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr1:23689562-23689563(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr1:23689631-23689632(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr1:23689645-23689646(-) m6A CDS       24284625//24981863//27773535//27371828//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate kshv-miR-K12-7-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
ZNF436
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-7-3p
Interactor2: ZNF436

Evidence Support:


Weak-Evidence Microarray//PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


[1]PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.
[2]PMID 22174674 Target region None
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EA.hy926 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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