Detail Information

Basic Information:


  VIRBase ID:  

VHID00448811

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-7-3p:           CREBZF:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-7-3p CREBZF
miRBase
Accession/Entrez ID		 MIMAT0002187 58487
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - SMILE//ZF

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CREBZF
chr11:85371357(-) A-I      3'UTR
chr11:85378838(-) A-I      intronic
chr11:85378310(-) A-I      intronic
chr11:85381512(-) A-I      intronic
chr11:85381061(-) A-I      intronic
chr11:85378836(-) A-I      intronic
chr11:85378822(-) A-I      intronic
chr11:85378839(-) A-I      intronic
chr11:85378390(-) A-I      intronic
chr11:85378389(-) A-I      intronic
chr11:85378892(-) A-I      intronic
chr11:85378757(-) A-I      intronic
chr11:85387846(-) A-I      intronic
chr11:85387938(-) A-I      intronic
chr11:85378745(-) A-I      intronic
chr11:85378320(-) A-I      intronic
chr11:85381617(-) A-I      intronic
chr11:85378784(-) A-I      intronic
chr11:85381123(-) A-I      intronic
chr11:85387753(-) A-I      intronic
chr11:85381515(-) A-I      intronic
chr11:85381016(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CREBZF
chr11:85370760-85370761(-) m6A 3'UTR       27773535
chr11:85370851-85370852(-) m6A 3'UTR       27773535
chr11:85371102-85371103(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr11:85371149-85371150(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr11:85371174-85371175(-) m6A 3'UTR       24284625//24981863//28052920//27773535//22608085
chr11:85371239-85371240(-) m6A 3'UTR//exon       24284625//24981863//28052920//27773535//22608085
chr11:85371393-85371394(-) m6A 3'UTR//exon       24209618//24981863//27773535//22608085
chr11:85371410-85371411(-) m6A 3'UTR//exon       24209618//24981863//27773535//22608085
chr11:85371430-85371431(-) m6A 3'UTR//exon       24209618//24981863//27773535//22608085
chr11:85371560-85371561(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr11:85371587-85371588(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr11:85371644-85371645(-) m6A 3'UTR//intron       24284625//24981863//26404942//27773535//22608085
chr11:85371978-85371979(-) m6A 3'UTR//intron       24981863
chr11:85372109-85372110(-) m6A 3'UTR//intron       24981863
chr11:85372814-85372815(-) m6A 3'UTR//intron       27773535
chr11:85372885-85372886(-) m6A 3'UTR//intron       27773535
chr11:85372921-85372922(-) m6A 3'UTR//intron       27773535
chr11:85374225-85374226(-) m6A 3'UTR//intron       27773535
chr11:85374233-85374234(-) m6A 3'UTR//intron       27773535
chr11:85374244-85374245(-) m6A 3'UTR//intron       27773535
chr11:85374260-85374261(-) m6A 3'UTR//intron       27773535
chr11:85374300-85374301(-) m6A 3'UTR//intron       27773535
chr11:85374336-85374337(-) m6A 3'UTR//intron       27773535
chr11:85374414-85374415(-) m6A 3'UTR//intron       27773535
chr11:85374591-85374592(-) m6A 3'UTR//CDS//exon       24284625//27773535//22608085
chr11:85374765-85374766(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr11:85374778-85374779(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr11:85374793-85374794(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chr11:85374924-85374925(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85374972-85374973(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85375026-85375027(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85375055-85375056(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85375091-85375092(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85375096-85375097(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85375191-85375192(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85375246-85375247(-) m1A CDS//intron       26863196
chr11:85375557-85375558(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85375569-85375570(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85375584-85375585(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85375601-85375602(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85375620-85375621(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:85376041-85376042(-) m6A 5'UTR//intron       24284625//24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate kshv-miR-K12-7-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
CREBZF
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-7-3p
Interactor2: CREBZF

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 22174674 Target region None
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line EA.hy926 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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