Basic Information:

  VIRBase ID:  

VHID00448452

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-7-3p:  MIMAT0002187          MDFIC:  NM_001166345     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-7-3p	MDFIC
miRBase Accession/Entrez ID	MIMAT0002187	29969
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HIC//MDFIC1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MDFIC	chr7:114642033(+) A-I      intronic chr7:114642014(+) A-I      intronic chr7:114642089(+) A-I      intronic chr7:114642071(+) A-I      intronic chr7:114623752(+) A-I      intronic chr7:114604723(+) A-I      intronic chr7:114652854(+) A-I      intronic chr7:114652975(+) A-I      intronic chr7:114604705(+) A-I      intronic chr7:114652853(+) A-I      intronic chr7:114647936(+) A-I      intronic chr7:114647805(+) A-I      intronic chr7:114647802(+) A-I      intronic chr7:114642210(+) A-I      intronic chr7:114642199(+) A-I      intronic chr7:114656462(+) A-I      3'UTR chr7:114656453(+) A-I      3'UTR chr7:114656432(+) A-I      3'UTR chr7:114656431(+) A-I      3'UTR chr7:114656472(+) A-I      3'UTR chr7:114647759(+) A-I      intronic chr7:114598731(+) A-I      intronic chr7:114647907(+) A-I      intronic chr7:114622689(+) A-I      intronic chr7:114647765(+) A-I      intronic chr7:114637650(+) A-I      intronic chr7:114652849(+) A-I      intronic chr7:114642178(+) A-I      intronic chr7:114652846(+) A-I      intronic chr7:114647814(+) A-I      intronic chr7:114647889(+) A-I      intronic chr7:114652886(+) A-I      intronic chr7:114652799(+) A-I      intronic chr7:114591120(+) A-I      intronic chr7:114603769(+) A-I      intronic chr7:114641966(+) A-I      intronic chr7:114642044(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MDFIC	chr7:114658248(+) A-C intron -    21725310 chr7:114598731(+) A-G intron -    22484847 chr7:114604629(+) A-G intron -    22484847 chr7:114608007(+) T-C intron -    22484847 chr7:114623698(+) A-C intron -    22484847 chr7:114641966(+) A-G intron -    22484847 chr7:114642019(+) T-C intron -    22484847 chr7:114642024(+) G-C intron -    22484847 chr7:114642044(+) A-G intron -    22484847 chr7:114642178(+) A-G intron -    22484847 chr7:114647759(+) A-G intron -    22484847 chr7:114647765(+) A-G intron -    22484847 chr7:114647814(+) A-G intron -    22484847 chr7:114647889(+) A-G intron -    22484847 chr7:114652799(+) A-G intron -    22484847 chr7:114652849(+) A-G intron -    22484847 chr7:114652886(+) A-G intron -    22484847 chr7:114656743(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MDFIC	chr7:114562237-114562238(+) m6A 5'UTR       24981863 chr7:114562944-114562945(+) m6A 5'UTR//intron       24209618//24981863 chr7:114655811-114655812(+) m6A 3'UTR//CDS       24981863 chr7:114655903-114655904(+) m6A 3'UTR//CDS       24209618//24981863//22608085 chr7:114655939-114655940(+) m6A 3'UTR//CDS       24209618//24981863//22608085 chr7:114656014-114656015(+) m6A 3'UTR       24981863//22608085 chr7:114656487-114656488(+) m6A 3'UTR       - chr7:114656510-114656511(+) m6A 3'UTR       - chr7:114656607-114656608(+) m6A 3'UTR       24981863 chr7:114656651-114656652(+) m6A 3'UTR       24981863 chr7:114656688-114656689(+) m6A 3'UTR       24981863 chr7:114656741-114656742(+) m6A 3'UTR       24981863//27773535 chr7:114656767-114656768(+) m6A 3'UTR       24981863//27773535//22608085 chr7:114656777-114656778(+) m6A 3'UTR       24981863//27773535//22608085 chr7:114656781-114656782(+) m6A 3'UTR       24981863 chr7:114656800-114656801(+) m6A 3'UTR       24981863//27773535//22608085 chr7:114656845-114656846(+) m6A 3'UTR       24981863//27773535//22608085 chr7:114656867-114656868(+) m6A 3'UTR       24981863//27773535//22608085 chr7:114656881-114656882(+) m6A 3'UTR       24981863//27773535//22608085 chr7:114656890-114656891(+) m6A 3'UTR       24981863//27773535//22608085 chr7:114656920-114656921(+) m6A 3'UTR       24981863//27773535//22608085 chr7:114656936-114656937(+) m6A 3'UTR       24981863//22608085 chr7:114656960-114656961(+) m6A 3'UTR       24981863//22608085 chr7:114657005-114657006(+) m6A 3'UTR       24981863 chr7:114658077-114658078(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	MDFIC	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-7-3p
Interactor2: MDFIC

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.