Detail Information

Basic Information:


  VIRBase ID:  

VHID00448451

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-7-3p:           LRP12:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-7-3p LRP12
miRBase
Accession/Entrez ID		 MIMAT0002187 29967
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - MIG13A//ST7

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LRP12
chr8:105563830(-) A-I      intronic
chr8:105523357(-) A-I      intronic
chr8:105523332(-) A-I      intronic
chr8:105556112(-) A-I      intronic
chr8:105561854(-) A-I      intronic
chr8:105523423(-) A-I      intronic
chr8:105524462(-) A-I      intronic
chr8:105561911(-) A-I      intronic
chr8:105524397(-) A-I      intronic
chr8:105561089(-) A-I      intronic
chr8:105560934(-) A-I      intronic
chr8:105524463(-) A-I      intronic
chr8:105561859(-) A-I      intronic
chr8:105560935(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LRP12
chr8:105501915-105501916(-) m6A 3'UTR//exon       27773535
chr8:105502047-105502048(-) m6A 3'UTR//exon       27773535
chr8:105502825-105502826(-) m6A 3'UTR//exon       24981863//27773535
chr8:105502964-105502965(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503059-105503060(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503071-105503072(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503101-105503102(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503126-105503127(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503206-105503207(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503222-105503223(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503335-105503336(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr8:105503513-105503514(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr8:105503569-105503570(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr8:105503669-105503670(-) m6A CDS//exon       24209618//24981863//22608085
chr8:105509400-105509401(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509439-105509440(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509557-105509558(-) m6A 5'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509735-105509736(-) m6A 5'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509864-105509865(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr8:105509910-105509911(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:105509949-105509950(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr8:105510021-105510022(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:105510054-105510055(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:105510290-105510291(-) m6A CDS//exon       24209618
chr8:105518064-105518065(-) m6A exon//intron       27773535
chr8:105518085-105518086(-) m6A exon//intron       27773535
chr8:105518094-105518095(-) m6A exon//intron       27773535
chr8:105518999-105519000(-) m6A exon//intron       27773535
chr8:105519053-105519054(-) m6A exon//intron       27773535
chr8:105519067-105519068(-) m6A exon//intron       27773535
chr8:105519079-105519080(-) m6A exon//intron       27773535
chr8:105519099-105519100(-) m6A exon//intron       27773535
chr8:105521290-105521291(-) m6A CDS//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate kshv-miR-K12-7-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
LRP12
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-7-3p
Interactor2: LRP12

Evidence Support:


Weak-Evidence Microarray
Support Database ViRBase

References:


PMID 22174674 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line EA.hy926 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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