Basic Information:

  VIRBase ID:  

VHID00448057

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-7-3p:  MIMAT0002187          SF3A1:  NM_005877     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-7-3p	SF3A1
miRBase Accession/Entrez ID	MIMAT0002187	10291
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRP21//PRPF21//SAP114//SF3A120

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SF3A1	chr22:30743234(-) A-I      intronic chr22:30743253(-) A-I      intronic chr22:30744041(-) A-I      intronic chr22:30744414(-) A-I      intronic chr22:30746347(-) A-I      intronic chr22:30746376(-) A-I      intronic chr22:30746401(-) A-I      intronic chr22:30747033(-) A-I      intronic chr22:30747045(-) A-I      intronic chr22:30747125(-) A-I      intronic chr22:30747131(-) A-I      intronic chr22:30747166(-) A-I      intronic chr22:30747188(-) A-I      intronic chr22:30747206(-) A-I      intronic chr22:30747235(-) A-I      intronic chr22:30747236(-) A-I      intronic chr22:30747666(-) A-I      intronic chr22:30747664(-) A-I      intronic chr22:30750861(-) A-I      intronic chr22:30746465(-) A-I      intronic chr22:30743115(-) A-I      intronic chr22:30745703(-) A-I      intronic chr22:30743250(-) A-I      intronic chr22:30743191(-) A-I      intronic chr22:30747622(-) A-I      intronic chr22:30747690(-) A-I      intronic chr22:30744397(-) A-I      intronic chr22:30745765(-) A-I      intronic chr22:30745801(-) A-I      intronic chr22:30747071(-) A-I      intronic chr22:30747627(-) A-I      intronic chr22:30744467(-) A-I      intronic chr22:30747738(-) A-I      intronic chr22:30743252(-) A-I      intronic chr22:30735605(-) A-I      intronic chr22:30747205(-) A-I      intronic chr22:30744067(-) A-I      intronic chr22:30747662(-) A-I      intronic chr22:30747600(-) A-I      intronic chr22:30747122(-) A-I      intronic chr22:30746349(-) A-I      intronic chr22:30745677(-) A-I      intronic chr22:30745797(-) A-I      intronic chr22:30743174(-) A-I      intronic chr22:30745852(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SF3A1	chr22:30730516-30730517(-) m6A 3'UTR       27773535 chr22:30730572-30730573(-) m6A 3'UTR       27773535 chr22:30730581-30730582(-) m6A 3'UTR       27773535 chr22:30731473-30731474(-) m6A CDS       27773535 chr22:30731644-30731645(-) m6A CDS       27773535 chr22:30731685-30731686(-) m6A CDS       27773535 chr22:30733018-30733019(-) m6A CDS       27773535 chr22:30733054-30733055(-) m6A CDS       24284625//27773535 chr22:30733061-30733062(-) m6A CDS       24284625//27773535 chr22:30733068-30733069(-) m6A CDS       24284625//27773535 chr22:30734986-30734987(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//27773536//22575960 chr22:30735101-30735102(-) m6A exon//intron       24981863//27773535 chr22:30735156-30735157(-) Am CDS//exon//intron       - chr22:30735171-30735172(-) m6A CDS//exon//intron       27773535//22575960 chr22:30736263-30736264(-) m6A CDS//exon//intron       27773535//22575960 chr22:30736278-30736279(-) m6A CDS//exon//intron       27773535//22575960 chr22:30736387-30736388(-) m6A exon//intron       24981863//27773535//27371828//27773536 chr22:30736718-30736719(-) m6A CDS//exon//intron       24981863//27371828 chr22:30736752-30736753(-) m6A CDS//exon//intron       24981863//27773535//27371828 chr22:30737705-30737706(-) m6A CDS//intron       24981863//28052920//26404942//27773535//27371828 chr22:30737711-30737712(-) m6A CDS//intron       24981863//28052920//26404942//27773535//27371828//22575960 chr22:30737746-30737747(-) m6A CDS//intron       24981863//28052920//26404942//27773535//27371828//22575960 chr22:30737870-30737871(-) m6A CDS//intron       24981863//28052920//26404942//27773535//27371828//27773536//22575960 chr22:30738208-30738209(-) m6A CDS//intron       24981863//28052920//26404942//27773535//27371828//27773536//22575960 chr22:30738215-30738216(-) m6A CDS//intron       24981863//28052920//26404942//27773535//27371828//27773536//22575960 chr22:30738555-30738556(-) m6A exon//intron       24981863//27773535//27371828 chr22:30738730-30738731(-) m6A exon//intron       24981863 chr22:30738788-30738789(-) m6A exon//intron       24981863 chr22:30738815-30738816(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863 chr22:30740933-30740934(-) m6A CDS//exon//intron       24284625//27773535 chr22:30741154-30741155(-) m6A CDS//exon//intron       24284625//27773535 chr22:30742252-30742253(-) m6A exon//intron       24284625//24981863//27773535 chr22:30742326-30742327(-) m6A CDS//exon//intron       24284625//24981863//26404942//27773535 chr22:30742439-30742440(-) m6A CDS//exon//intron       24284625//26404942//27773535 chr22:30748585-30748586(-) m6A exon//intron       27773535 chr22:30749050-30749051(-) m1A CDS//exon//intron       26863410//26863196 chr22:30752721-30752722(-) m6A CDS//exon       27371828//27773536 chr22:30752769-30752770(-) m6A CDS//exon       24981863//27371828//27773536 chr22:30752805-30752806(-) m6A 5'UTR//exon       24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	SF3A1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-7-3p
Interactor2: SF3A1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.