Basic Information:

  VIRBase ID:  

VHID00447862

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-7-3p:  MIMAT0002187          EED:  NM_001308007     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-7-3p	EED
miRBase Accession/Entrez ID	MIMAT0002187	8726
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	COGIS//HEED//WAIT1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EED	chr11:85974831(+) A-I      intronic chr11:85974807(+) A-I      intronic chr11:85969932(+) A-I      intronic chr11:85970110(+) A-I      intronic chr11:85964951(+) A-I      intronic chr11:85965022(+) A-I      intronic chr11:85965382(+) A-I      intronic chr11:85965621(+) A-I      intronic chr11:85965635(+) A-I      intronic chr11:85963865(+) A-I      intronic chr11:85970436(+) A-I      intronic chr11:85973623(+) A-I      intronic chr11:85964025(+) A-I      intronic chr11:85970074(+) A-I      intronic chr11:85964900(+) A-I      intronic chr11:85964835(+) A-I      intronic chr11:85965568(+) A-I      intronic chr11:85964818(+) A-I      intronic chr11:85964840(+) A-I      intronic chr11:85964861(+) A-I      intronic chr11:85964870(+) A-I      intronic chr11:85964925(+) A-I      intronic chr11:85970090(+) A-I      intronic chr11:85970075(+) A-I      intronic chr11:85983307(+) A-I      intronic chr11:85974809(+) A-I      intronic chr11:85964052(+) A-I      intronic chr11:85969654(+) A-I      intronic chr11:85974835(+) A-I      intronic chr11:85964943(+) A-I      intronic chr11:85974836(+) A-I      intronic chr11:85965480(+) A-I      intronic chr11:85969662(+) A-I      intronic chr11:85965830(+) A-I      intronic chr11:85973624(+) A-I      intronic chr11:85965839(+) A-I      intronic chr11:85965765(+) A-I      intronic chr11:85965729(+) A-I      intronic chr11:85965005(+) A-I      intronic chr11:85969727(+) A-I      intronic chr11:85965080(+) A-I      intronic chr11:85974777(+) A-I      intronic chr11:85964940(+) A-I      intronic chr11:85974837(+) A-I      intronic chr11:85964970(+) A-I      intronic chr11:85964956(+) A-I      intronic chr11:85973608(+) A-I      intronic chr11:85965623(+) A-I      intronic chr11:85973109(+) A-I      intronic chr11:85984145(+) A-I      intronic chr11:85973979(+) A-I      intronic chr11:85964930(+) A-I      intronic chr11:85970487(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EED	chr11:85963865(+) A-G intron -    22484847 chr11:85964930(+) A-G intron -    22484847 chr11:85964956(+) A-G intron -    22484847 chr11:85971557(+) T-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EED	chr11:85955776-85955777(+) m6A 5'UTR       24981863 chr11:85955803-85955804(+) m6A 5'UTR       24284625//24209618//25456834//24981863 chr11:85955939-85955940(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr11:85955971-85955972(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr11:85955987-85955988(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr11:85956249-85956250(+) m6A 5'UTR       24209618//24981863//22575960 chr11:85956307-85956308(+) m6A CDS       24209618//24981863//22575960 chr11:85956353-85956354(+) m6A CDS//exon       24209618//24981863//22575960 chr11:85956365-85956366(+) m6A CDS//exon       24209618//24981863//22575960 chr11:85961368-85961369(+) m6A CDS//exon//intron       24209618//24981863//27773535//22575960 chr11:85961395-85961396(+) m6A CDS//exon//intron       24209618//24981863//27773535//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	EED	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-7-3p
Interactor2: EED

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Rep//RNAHybrid//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).