Basic Information:

  VIRBase ID:  

VHID00447402

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-7-3p:  MIMAT0002187          IMPDH1:  NM_183243     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-7-3p	IMPDH1
miRBase Accession/Entrez ID	MIMAT0002187	3614
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	IMPD//IMPD1//IMPDH-I//LCA11//RP10//sWSS2608

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IMPDH1	chr7:128043512(-) A-I      intronic chr7:128043529(-) A-I      intronic chr7:128043420(-) A-I      intronic chr7:128032412(-) A-I      3'UTR chr7:128032420(-) A-I      3'UTR chr7:128032372(-) A-I      3'UTR chr7:128032391(-) A-I      3'UTR chr7:128032393(-) A-I      3'UTR chr7:128032375(-) A-I      3'UTR chr7:128032413(-) A-I      3'UTR chr7:128043394(-) A-I      intronic chr7:128042253(-) A-I      intronic chr7:128042294(-) A-I      intronic chr7:128042350(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IMPDH1	chr7:128032451-128032452(-) m6A 3'UTR       24284625 chr7:128032509-128032510(-) m6A 3'UTR       24284625 chr7:128032871-128032872(-) m6A 3'UTR       24284625 chr7:128032909-128032910(-) m6A 3'UTR       24284625 chr7:128034374-128034375(-) m6A 3'UTR//CDS//exon       27773535 chr7:128034602-128034603(-) m6A 3'UTR//CDS//exon       24981863//27773535 chr7:128034748-128034749(-) m6A exon//intron       27773535//27371828 chr7:128035221-128035222(-) m6A 3'UTR//CDS//exon       22575960 chr7:128035229-128035230(-) m6A 3'UTR//CDS       22575960 chr7:128038591-128038592(-) m6A 3'UTR//CDS//exon       - chr7:128038597-128038598(-) m6A 3'UTR//CDS//exon       - chr7:128040215-128040216(-) m6A 3'UTR//CDS//exon       - chr7:128041105-128041106(-) m6A 3'UTR//CDS//exon       24284625 chr7:128043778-128043779(-) m6A 3'UTR//CDS//exon       24284625//22575960 chr7:128045910-128045911(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960 chr7:128049526-128049527(-) m6A 5'UTR//CDS//exon//intron       27371828//27773536 chr7:128049871-128049872(-) m6A 5'UTR//CDS//exon       24981863//27371828//27773536 chr7:128050035-128050036(-) m6A 5'UTR//exon       24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-7-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	IMPDH1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-7-3p
Interactor2: IMPDH1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.