Detail Information

Basic Information:


  VIRBase ID:  

VHID00447042

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:           CCDC88C:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-8-3p CCDC88C
miRBase
Accession/Entrez ID		 MIMAT0002186 440193
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - DAPLE//HKRP2//HYC1//KIAA1509//SCA40

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CCDC88C
chr14:91811300(-) A-I      intronic
chr14:91811304(-) A-I      intronic
chr14:91811311(-) A-I      intronic
chr14:91811316(-) A-I      intronic
chr14:91811357(-) A-I      intronic
chr14:91776893(-) A-I      intronic
chr14:91776899(-) A-I      intronic
chr14:91776954(-) A-I      intronic
chr14:91776915(-) A-I      intronic
chr14:91776919(-) A-I      intronic
chr14:91776930(-) A-I      intronic
chr14:91776951(-) A-I      intronic
chr14:91789426(-) A-I      intronic
chr14:91803939(-) A-I      intronic
chr14:91810941(-) A-I      intronic
chr14:91810984(-) A-I      intronic
chr14:91850530(-) A-I      intronic
chr14:91811243(-) A-I      intronic
chr14:91811336(-) A-I      intronic
chr14:91811405(-) A-I      intronic
chr14:91813005(-) A-I      intronic
chr14:91813134(-) A-I      intronic
chr14:91878124(-) A-I      intronic
chr14:91784513(-) A-I      intronic
chr14:91784636(-) A-I      intronic
chr14:91813142(-) A-I      intronic
chr14:91813196(-) A-I      intronic
chr14:91813218(-) A-I      intronic
chr14:91813237(-) A-I      intronic
chr14:91814426(-) A-I      intronic
chr14:91814442(-) A-I      intronic
chr14:91814446(-) A-I      intronic
chr14:91814760(-) A-I      intronic
chr14:91814816(-) A-I      intronic
chr14:91829089(-) A-I      intronic
chr14:91847985(-) A-I      intronic
chr14:91813143(-) A-I      intronic
chr14:91847994(-) A-I      intronic
chr14:91864889(-) A-I      intronic
chr14:91864892(-) A-I      intronic
chr14:91865010(-) A-I      intronic
chr14:91867733(-) A-I      intronic
chr14:91867746(-) A-I      intronic
chr14:91867790(-) A-I      intronic
chr14:91867847(-) A-I      intronic
chr14:91867860(-) A-I      intronic
chr14:91867901(-) A-I      intronic
chr14:91867925(-) A-I      intronic
chr14:91867951(-) A-I      intronic
chr14:91868498(-) A-I      intronic
chr14:91868552(-) A-I      intronic
chr14:91868612(-) A-I      intronic
chr14:91874394(-) A-I      intronic
chr14:91878980(-) A-I      intronic
chr14:91878984(-) A-I      intronic
chr14:91881936(-) A-I      intronic
chr14:91882012(-) A-I      intronic
chr14:91882025(-) A-I      intronic
chr14:91868589(-) A-I      intronic
chr14:91743591(-) A-I      intronic
chr14:91811233(-) A-I      intronic
chr14:91811701(-) A-I      intronic
chr14:91813060(-) A-I      intronic
chr14:91811404(-) A-I      intronic
chr14:91809427(-) A-I      intronic
chr14:91868588(-) A-I      intronic
chr14:91867858(-) A-I      intronic
chr14:91753752(-) A-I      intronic
chr14:91753939(-) A-I      intronic
chr14:91784665(-) A-I      intronic
chr14:91874306(-) A-I      intronic
chr14:91813006(-) A-I      intronic
chr14:91813161(-) A-I      intronic
chr14:91878231(-) A-I      intronic
chr14:91874300(-) A-I      intronic
chr14:91813186(-) A-I      intronic
chr14:91753880(-) A-I      intronic
chr14:91753932(-) A-I      intronic
chr14:91867857(-) A-I      intronic
chr14:91784730(-) A-I      intronic
chr14:91753956(-) A-I      intronic
chr14:91755012(-) A-I      intronic
chr14:91755035(-) A-I      intronic
chr14:91867859(-) A-I      intronic
chr14:91755126(-) A-I      intronic
chr14:91767975(-) A-I      intronic
chr14:91767978(-) A-I      intronic
chr14:91782888(-) A-I      intronic
chr14:91782915(-) A-I      intronic
chr14:91786257(-) A-I      intronic
chr14:91783045(-) A-I      intronic
chr14:91784498(-) A-I      intronic
chr14:91784683(-) A-I      intronic
chr14:91784698(-) A-I      intronic
chr14:91812998(-) A-I      intronic
chr14:91782891(-) A-I      intronic
chr14:91778907(-) A-I      intronic
chr14:91784754(-) A-I      intronic
chr14:91814778(-) A-I      intronic
chr14:91811308(-) A-I      intronic
chr14:91874288(-) A-I      intronic
chr14:91784727(-) A-I      intronic
chr14:91813217(-) A-I      intronic
chr14:91865006(-) A-I      intronic
chr14:91814765(-) A-I      intronic
chr14:91813121(-) A-I      intronic
chr14:91878095(-) A-I      intronic
chr14:91810437(-) A-I      intronic
chr14:91868435(-) A-I      intronic
chr14:91814746(-) A-I      intronic
chr14:91784673(-) A-I      intronic
chr14:91803808(-) A-I      intronic
chr14:91782905(-) A-I      intronic
chr14:91811249(-) A-I      intronic
chr14:91778649(-) A-I      intronic
chr14:91755036(-) A-I      intronic
chr14:91829084(-) A-I      intronic
chr14:91753908(-) A-I      intronic
chr14:91813004(-) A-I      intronic
chr14:91813191(-) A-I      intronic
chr14:91868450(-) A-I      intronic
chr14:91784529(-) A-I      intronic
chr14:91784758(-) A-I      intronic
chr14:91874251(-) A-I      intronic
chr14:91784719(-) A-I      intronic
chr14:91813131(-) A-I      intronic
chr14:91813077(-) A-I      intronic
chr14:91782943(-) A-I      intronic
chr14:91811033(-) A-I      intronic
chr14:91874194(-) A-I      intronic
chr14:91811284(-) A-I      intronic
chr14:91753742(-) A-I      intronic
chr14:91825754(-) A-I      intronic
chr14:91811223(-) A-I      intronic
chr14:91813160(-) A-I      intronic
chr14:91868525(-) A-I      intronic
chr14:91810373(-) A-I      intronic
chr14:91847926(-) A-I      intronic
chr14:91814740(-) A-I      intronic
chr14:91811756(-) A-I      intronic
chr14:91811269(-) A-I      intronic
chr14:91811209(-) A-I      intronic
chr14:91811309(-) A-I      intronic
chr14:91811237(-) A-I      intronic
chr14:91755084(-) A-I      intronic
chr14:91868446(-) A-I      intronic
chr14:91814488(-) A-I      intronic
chr14:91867817(-) A-I      intronic
chr14:91811417(-) A-I      intronic
chr14:91778710(-) A-I      intronic
chr14:91881955(-) A-I      intronic
chr14:91775366(-) A-I      intronic
chr14:91753927(-) A-I      intronic
chr14:91811032(-) A-I      intronic
chr14:91874302(-) A-I      intronic
chr14:91874273(-) A-I      intronic
chr14:91868568(-) A-I      intronic
chr14:91813180(-) A-I      intronic
chr14:91782878(-) A-I      intronic
chr14:91786286(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CCDC88C
chr14:91753908(-) A-I intron -    22327324
chr14:91814740(-) A-I intron -    22327324
chr14:91814746(-) A-I intron -    22327324
chr14:91753908(-) A-G intron -    22484847
chr14:91755036(-) A-G intron -    22484847
chr14:91784665(-) A-G intron -    22484847
chr14:91814740(-) A-G intron -    22484847
chr14:91814746(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CCDC88C
chr14:91737671-91737672(-) m6A 3'UTR       27773535
chr14:91737692-91737693(-) m6A 3'UTR       27773535
chr14:91737697-91737698(-) m6A 3'UTR       27773535
chr14:91737705-91737706(-) m6A 3'UTR       27773535
chr14:91737776-91737777(-) m6A 3'UTR       27773535
chr14:91737845-91737846(-) m6A 3'UTR       27773535
chr14:91737850-91737851(-) m6A 3'UTR       27773535
chr14:91738466-91738467(-) m6A 3'UTR       25456834//27371828
chr14:91738502-91738503(-) m6A 3'UTR       25456834//27371828
chr14:91738634-91738635(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr14:91738660-91738661(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr14:91738680-91738681(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr14:91738702-91738703(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr14:91738727-91738728(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828
chr14:91738815-91738816(-) m6A 3'UTR       24284625//25456834//24981863//27371828
chr14:91738936-91738937(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27371828
chr14:91738944-91738945(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27371828
chr14:91738997-91738998(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//27773536//22608085
chr14:91739062-91739063(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//27773536
chr14:91739240-91739241(-) m6A 3'UTR//CDS       27371828
chr14:91739410-91739411(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//27773536
chr14:91739474-91739475(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//27773536
chr14:91739537-91739538(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//27773536
chr14:91739589-91739590(-) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//28052920//27371828//27773536
chr14:91739712-91739713(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//27773536
chr14:91739748-91739749(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr14:91739787-91739788(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr14:91739794-91739795(-) m6A 3'UTR//CDS       24284625//25456834//24981863//28052920//27371828//22575960
chr14:91739913-91739914(-) m6A 3'UTR//CDS//exon       27773535//27371828
chr14:91749747-91749748(-) m6A 3'UTR//CDS//exon       27773535
chr14:91749844-91749845(-) m6A 3'UTR//CDS//exon       27773536
chr14:91751955-91751956(-) m6A 3'UTR//5'UTR//intron       27773535
chr14:91752128-91752129(-) m6A CDS//intron       27371828
chr14:91752134-91752135(-) m6A CDS//intron       27371828
chr14:91752140-91752141(-) m6A CDS//intron       27371828
chr14:91755519-91755520(-) m6A CDS//exon       27773536
chr14:91755567-91755568(-) m6A CDS//exon       27773536
chr14:91755597-91755598(-) m6A CDS//exon       27773536
chr14:91757403-91757404(-) m6A CDS//exon       24981863
chr14:91757425-91757426(-) m6A CDS       24981863//27773535
chr14:91760552-91760553(-) m6A CDS       24981863//27773535
chr14:91760561-91760562(-) m6A CDS       24981863//27773535
chr14:91760582-91760583(-) m6A CDS       24981863//27773535
chr14:91760639-91760640(-) m6A CDS       24981863//27773535
chr14:91763661-91763662(-) m6A CDS       27773535//27371828//27773536
chr14:91763682-91763683(-) m6A CDS       27371828//27773536
chr14:91763689-91763690(-) m6A CDS       27371828//27773536
chr14:91763754-91763755(-) m6A CDS       27371828//27773536
chr14:91763764-91763765(-) m6A CDS       27371828//27773536
chr14:91766273-91766274(-) m6A CDS       25456834//27371828//27773536
chr14:91766297-91766298(-) m6A CDS       25456834//27371828//27773536
chr14:91766322-91766323(-) m6A CDS       25456834//24981863//28052920//27371828//27773536
chr14:91770057-91770058(-) Gm CDS       -
chr14:91770090-91770091(-) m6A CDS       24981863//27371828//27773536
chr14:91770170-91770171(-) m6A CDS       24981863//27371828//27773536
chr14:91770257-91770258(-) m6A CDS       27371828//27773536
chr14:91770314-91770315(-) m6A CDS       24284625//27773535//27371828//27773536
chr14:91772122-91772123(-) m6A CDS       24284625//27773535//27371828//27773536
chr14:91772128-91772129(-) m6A CDS       24284625//27773535//27371828//27773536
chr14:91772168-91772169(-) m6A CDS       24284625//27773535//27371828//27773536
chr14:91772212-91772213(-) m6A CDS       27371828
chr14:91772231-91772232(-) m6A CDS       27371828
chr14:91773406-91773407(-) m6A CDS       27371828
chr14:91773485-91773486(-) m6A CDS       24981863//27773535//27371828
chr14:91773511-91773512(-) m6A CDS       24981863//27773535//27371828
chr14:91773538-91773539(-) m6A CDS       24981863//27773535//27371828
chr14:91773551-91773552(-) m6A CDS       24981863//27773535//27371828
chr14:91774792-91774793(-) m6A CDS       24981863//28052920//27773535//27371828
chr14:91776264-91776265(-) m6A CDS       24981863//27773535//27371828//27773536
chr14:91776280-91776281(-) m6A CDS       24981863//27773535//27371828//27773536
chr14:91779443-91779444(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr14:91779475-91779476(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr14:91779484-91779485(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr14:91779541-91779542(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr14:91779576-91779577(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr14:91779703-91779704(-) m6A CDS       24284625//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr14:91779754-91779755(-) m6A CDS       24284625//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr14:91779809-91779810(-) m6A CDS       24284625//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr14:91779856-91779857(-) m6A CDS       24284625//25456834//24981863//28052920//27371828//27773536//22608085
chr14:91779970-91779971(-) m6A CDS       24284625//25456834//27773535//27371828//27773536//22608085
chr14:91780016-91780017(-) m6A CDS       24284625//25456834//28052920//27773535//27371828//27773536//22575960//22608085
chr14:91780042-91780043(-) m6A CDS       24284625//25456834//27773535//27371828//27773536//22575960//22608085
chr14:91780111-91780112(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr14:91780130-91780131(-) m6A CDS       24284625//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr14:91780135-91780136(-) m6A CDS       24284625//25456834//24981863//28052920//27371828//27773536//22575960//22608085
chr14:91780193-91780194(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr14:91780303-91780304(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr14:91780384-91780385(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr14:91780468-91780469(-) m6A CDS//exon       24981863//27773535//27371828
chr14:91780486-91780487(-) m6A CDS//exon       24981863//27773535//27371828
chr14:91782019-91782020(-) m6A CDS//exon       24981863//27773535//27371828
chr14:91782073-91782074(-) m6A CDS//exon       24981863//27773535//27371828
chr14:91782115-91782116(-) m6A CDS//exon       24981863//27773535//27371828
chr14:91782169-91782170(-) m6A exon//intron       24981863//27773535//27371828
chr14:91787482-91787483(-) m6A CDS       24981863//27773535//27371828
chr14:91804430-91804431(-) m6A CDS//exon       27773535
chr14:91804853-91804854(-) m6A CDS//exon       27371828
chr14:91804869-91804870(-) m6A CDS//exon       27371828
chr14:91804880-91804881(-) m6A CDS//exon       27371828
chr14:91804887-91804888(-) m6A CDS//exon       27371828
chr14:91804903-91804904(-) m6A CDS//exon       27371828
chr14:91805687-91805688(-) m6A CDS//exon       27371828//27773536
chr14:91805777-91805778(-) m6A CDS//exon       27371828//27773536
chr14:91805795-91805796(-) m6A CDS//exon       27371828//27773536
chr14:91844998-91844999(-) m6A 3'UTR//intron       27773535
chr14:91845171-91845172(-) m6A 3'UTR//intron       27773535
chr14:91845208-91845209(-) m6A 3'UTR//intron       27773535
chr14:91845261-91845262(-) m6A 3'UTR//intron       27773535
chr14:91845293-91845294(-) m6A 3'UTR//intron       27773535
chr14:91845402-91845403(-) m6A 3'UTR//intron       25456834//27773535//27371828
chr14:91845497-91845498(-) m6A 3'UTR//intron       27773535
chr14:91845531-91845532(-) m6A 3'UTR//intron       -
chr14:91845599-91845600(-) m6A 3'UTR//intron       -
chr14:91845758-91845759(-) m6A 3'UTR//intron       -
chr14:91845868-91845869(-) m6A 3'UTR//intron       -
chr14:91845883-91845884(-) m6A 3'UTR//intron       -
chr14:91845897-91845898(-) m6A 3'UTR//intron       -
chr14:91846125-91846126(-) m6A 3'UTR//intron       25456834//27371828
chr14:91846130-91846131(-) m6A 3'UTR//intron       25456834//27371828
chr14:91846137-91846138(-) m6A 3'UTR//intron       25456834//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate kshv-miR-K12-8-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
CCDC88C
Centrosome Cells (HeLa-Kyoto|HeLa)     33649340
Chromatin K562 cells     -
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-8-3p
Interactor2: CCDC88C

Evidence Support:


Weak-Evidence Microarray
Support Database ViRBase

References:


PMID 22174674 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line DG-75 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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