Basic Information:

  VIRBase ID:  

VHID00447040

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          ZBTB34:  NM_001099270     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	ZBTB34
miRBase Accession/Entrez ID	MIMAT0002186	403341
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ZNF918

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZBTB34	chr9:129640128(+) A-I      intronic chr9:129641225(+) A-I      intronic chr9:129641238(+) A-I      intronic chr9:129633742(+) A-I      intronic chr9:129633741(+) A-I      intronic chr9:129636045(+) A-I      intronic chr9:129641223(+) A-I      intronic chr9:129640704(+) A-I      intronic chr9:129640694(+) A-I      intronic chr9:129640690(+) A-I      intronic chr9:129633746(+) A-I      intronic chr9:129640494(+) A-I      intronic chr9:129634365(+) A-I      intronic chr9:129640539(+) A-I      intronic chr9:129634413(+) A-I      intronic chr9:129633745(+) A-I      intronic chr9:129640155(+) A-I      intronic chr9:129640198(+) A-I      intronic chr9:129646380(+) A-I      3'UTR chr9:129633113(+) A-I      intronic chr9:129634140(+) A-I      intronic chr9:129640524(+) A-I      intronic chr9:129640176(+) A-I      intronic chr9:129641128(+) A-I      intronic chr9:129640163(+) A-I      intronic chr9:129641265(+) A-I      intronic chr9:129641103(+) A-I      intronic chr9:129641097(+) A-I      intronic chr9:129641183(+) A-I      intronic chr9:129640642(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZBTB34	chr9:129623014-129623015(+) m6A 5'UTR       24284625 chr9:129641651-129641652(+) m6A 5'UTR//intron       24284625//22608085 chr9:129641694-129641695(+) m6A CDS       24284625//24981863//22575960//22608085 chr9:129641761-129641762(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr9:129641779-129641780(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr9:129641865-129641866(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642147-129642148(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642291-129642292(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642342-129642343(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642357-129642358(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642484-129642485(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr9:129642732-129642733(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642927-129642928(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642967-129642968(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643038-129643039(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643088-129643089(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643105-129643106(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643111-129643112(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643215-129643216(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643330-129643331(+) m6A 3'UTR       24284625//24981863//22608085 chr9:129643411-129643412(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:129643442-129643443(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:129644892-129644893(+) m6A 3'UTR       - chr9:129644935-129644936(+) m6A 3'UTR       - chr9:129644970-129644971(+) m6A 3'UTR       - chr9:129646203-129646204(+) m6A 3'UTR       24284625//24981863 chr9:129646209-129646210(+) m6A 3'UTR       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	ZBTB34	Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: ZBTB34

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells//EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).