Detail Information

Basic Information:


  VIRBase ID:  

VHID00446979

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:           THAP5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-8-3p THAP5
miRBase
Accession/Entrez ID		 MIMAT0002186 168451
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - -

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR THAP5
chr7:108205877(-) A-I      intronic
chr7:108205849(-) A-I      intronic
chr7:108205846(-) A-I      intronic
chr7:108205981(-) A-I      intronic
chr7:108206005(-) A-I      intronic
chr7:108206010(-) A-I      intronic
chr7:108208712(-) A-I      intronic
chr7:108206006(-) A-I      intronic
chr7:108205929(-) A-I      intronic
chr7:108205998(-) A-I      intronic
chr7:108203725(-) A-I      3'UTR
chr7:108203870(-) A-I      3'UTR
chr7:108203882(-) A-I      3'UTR
chr7:108208930(-) A-I      intronic
chr7:108208865(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED THAP5
chr7:108203800(-) C-T exon 3'UTR    22484847
chr7:108203870(-) A-G exon 3'UTR    22484847
chr7:108203873(-) A-G exon 3'UTR    22484847
chr7:108203920(-) A-G exon 3'UTR    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase THAP5
chr7:108204343-108204344(-) m6A 3'UTR//intron       27773535
chr7:108204368-108204369(-) m6A 3'UTR//intron       27773535
chr7:108204466-108204467(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr7:108204502-108204503(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr7:108204529-108204530(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr7:108204562-108204563(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr7:108204578-108204579(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr7:108204583-108204584(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr7:108204616-108204617(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr7:108204668-108204669(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr7:108204704-108204705(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr7:108204759-108204760(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr7:108204826-108204827(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr7:108204844-108204845(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr7:108204859-108204860(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr7:108204879-108204880(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr7:108204887-108204888(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr7:108204908-108204909(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr7:108204917-108204918(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr7:108204923-108204924(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr7:108204939-108204940(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr7:108204976-108204977(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr7:108205028-108205029(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22608085
chr7:108205044-108205045(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085
chr7:108205115-108205116(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085
chr7:108205161-108205162(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085
chr7:108205278-108205279(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085
chr7:108205297-108205298(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085
chr7:108205312-108205313(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085
chr7:108205356-108205357(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085
chr7:108205446-108205447(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085
chr7:108205511-108205512(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//22608085
chr7:108205541-108205542(-) m6A CDS//exon//intron       27773535//22608085
chr7:108206280-108206281(-) m6A CDS//exon//intron       27773535
chr7:108206318-108206319(-) m6A CDS//exon//intron       27773535
chr7:108209591-108209592(-) m6A 5'UTR//exon//intron       27773535
chr7:108209622-108209623(-) m6A 5'UTR//exon//intron       27773535
chr7:108209954-108209955(-) m6A CDS//exon       27371828//27773536
chr7:108209963-108209964(-) m6A CDS//exon       24981863//27371828//27773536
chr7:108209978-108209979(-) m6A CDS//exon       24981863//27371828//27773536
chr7:108210090-108210091(-) m6A 5'UTR//exon       24284625//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate kshv-miR-K12-8-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
THAP5
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-8-3p
Interactor2: THAP5

Evidence Support:


Weak-Evidence Microarray
Support Database ViRBase

References:


PMID 22174674 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line DG-75 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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