Basic Information:

  VIRBase ID:  

VHID00446947

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          FAM199X:  NM_207318     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	FAM199X
miRBase Accession/Entrez ID	MIMAT0002186	139231
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CXorf39

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM199X	chrX:103414483(+) A-I      intronic chrX:103414464(+) A-I      intronic chrX:103417716(+) A-I      intronic chrX:103414446(+) A-I      intronic chrX:103414438(+) A-I      intronic chrX:103418785(+) A-I      intronic chrX:103418700(+) A-I      intronic chrX:103422980(+) A-I      intronic chrX:103423571(+) A-I      intronic chrX:103417675(+) A-I      intronic chrX:103417707(+) A-I      intronic chrX:103416902(+) A-I      intronic chrX:103416996(+) A-I      intronic chrX:103417735(+) A-I      intronic chrX:103417700(+) A-I      intronic chrX:103423750(+) A-I      intronic chrX:103417857(+) A-I      intronic chrX:103417002(+) A-I      intronic chrX:103418862(+) A-I      intronic chrX:103414423(+) A-I      intronic chrX:103418770(+) A-I      intronic chrX:103422917(+) A-I      intronic chrX:103414329(+) A-I      intronic chrX:103414274(+) A-I      intronic chrX:103418777(+) A-I      intronic chrX:103423610(+) A-I      intronic chrX:103414421(+) A-I      intronic chrX:103423045(+) A-I      intronic chrX:103423752(+) A-I      intronic chrX:103414429(+) A-I      intronic chrX:103414388(+) A-I      intronic chrX:103422922(+) A-I      intronic chrX:103422977(+) A-I      intronic chrX:103423609(+) A-I      intronic chrX:103423087(+) A-I      intronic chrX:103417676(+) A-I      intronic chrX:103414297(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM199X	chrX:103435264(+) T-G intron -    21725310 chrX:103417676(+) A-G intron -    22484847 chrX:103417700(+) A-G intron -    22484847 chrX:103418770(+) A-G intron -    22484847 chrX:103418777(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM199X	chrX:103411386-103411387(+) m6A 5'UTR       - chrX:103432895-103432896(+) m6A CDS//intron       22575960 chrX:103432907-103432908(+) m6A CDS//intron       22575960 chrX:103434427-103434428(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chrX:103435673-103435674(+) m6A 3'UTR//exon       - chrX:103435701-103435702(+) m6A 3'UTR//exon       - chrX:103435818-103435819(+) m6A 3'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	FAM199X	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: FAM199X

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).