Basic Information:

  VIRBase ID:  

VHID00446942

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          TAF8:  NM_138572     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	TAF8
miRBase Accession/Entrez ID	MIMAT0002186	129685
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	II//TAF//TAF(II)43//TAFII-43//TAFII43//TBN

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TAF8	chr6:42031030(+) A-I      ncRNA chr6:42031101(+) A-I      ncRNA chr6:42031091(+) A-I      ncRNA chr6:42031090(+) A-I      ncRNA chr6:42031062(+) A-I      ncRNA chr6:42032231(+) A-I      intronic chr6:42032254(+) A-I      intronic chr6:42032255(+) A-I      intronic chr6:42032564(+) A-I      intronic chr6:42032158(+) A-I      intronic chr6:42032014(+) A-I      intronic chr6:42030489(+) A-I      intronic chr6:42041819(+) A-I      intronic chr6:42041862(+) A-I      intronic chr6:42021101(+) A-I      intronic chr6:42021149(+) A-I      intronic chr6:42021152(+) A-I      intronic chr6:42021156(+) A-I      intronic chr6:42025935(+) A-I      intronic chr6:42025940(+) A-I      intronic chr6:42025946(+) A-I      intronic chr6:42025975(+) A-I      intronic chr6:42042292(+) A-I      intronic chr6:42042296(+) A-I      intronic chr6:42042334(+) A-I      intronic chr6:42026974(+) A-I      intronic chr6:42026994(+) A-I      intronic chr6:42030328(+) A-I      intronic chr6:42030342(+) A-I      intronic chr6:42044003(+) A-I      intronic chr6:42044028(+) A-I      intronic chr6:42044138(+) A-I      intronic chr6:42026971(+) A-I      intronic chr6:42026970(+) A-I      intronic chr6:42026866(+) A-I      intronic chr6:42026083(+) A-I      intronic chr6:42025850(+) A-I      intronic chr6:42021253(+) A-I      intronic chr6:42021252(+) A-I      intronic chr6:42021228(+) A-I      intronic chr6:42021144(+) A-I      intronic chr6:42021140(+) A-I      intronic chr6:42021107(+) A-I      intronic chr6:42020910(+) A-I      intronic chr6:42020322(+) A-I      intronic chr6:42020294(+) A-I      intronic chr6:42020257(+) A-I      intronic chr6:42020243(+) A-I      intronic chr6:42020234(+) A-I      intronic chr6:42020199(+) A-I      intronic chr6:42020189(+) A-I      intronic chr6:42020153(+) A-I      intronic chr6:42020083(+) A-I      intronic chr6:42019636(+) A-I      intronic chr6:42019513(+) A-I      intronic chr6:42035555(+) A-I      intronic chr6:42032990(+) A-I      intronic chr6:42032574(+) A-I      intronic chr6:42035571(+) A-I      intronic chr6:42035595(+) A-I      intronic chr6:42046707(+) A-I      3'UTR chr6:42048154(+) A-I      3'UTR chr6:42048197(+) A-I      3'UTR chr6:42048210(+) A-I      3'UTR chr6:42048215(+) A-I      3'UTR chr6:42048338(+) A-I      3'UTR chr6:42046683(+) A-I      3'UTR chr6:42046676(+) A-I      3'UTR chr6:42046664(+) A-I      3'UTR chr6:42050312(+) A-I      3'UTR chr6:42049479(+) A-I      3'UTR chr6:42049428(+) A-I      3'UTR chr6:42049273(+) A-I      3'UTR chr6:42049246(+) A-I      3'UTR chr6:42049211(+) A-I      3'UTR chr6:42049171(+) A-I      3'UTR chr6:42049143(+) A-I      3'UTR chr6:42045889(+) A-I      3'UTR chr6:42045864(+) A-I      3'UTR chr6:42045829(+) A-I      3'UTR chr6:42045768(+) A-I      3'UTR chr6:42045756(+) A-I      3'UTR chr6:42045723(+) A-I      3'UTR chr6:42045660(+) A-I      3'UTR chr6:42045641(+) A-I      3'UTR chr6:42045599(+) A-I      3'UTR chr6:42046596(+) A-I      3'UTR chr6:42046640(+) A-I      3'UTR chr6:42046650(+) A-I      3'UTR chr6:42046653(+) A-I      3'UTR chr6:42045537(+) A-I      3'UTR chr6:42048374(+) A-I      3'UTR chr6:42047405(+) A-I      3'UTR chr6:42047453(+) A-I      3'UTR chr6:42047513(+) A-I      3'UTR chr6:42046855(+) A-I      3'UTR chr6:42046820(+) A-I      3'UTR chr6:42046812(+) A-I      3'UTR chr6:42046810(+) A-I      3'UTR chr6:42046801(+) A-I      3'UTR chr6:42046775(+) A-I      3'UTR chr6:42046772(+) A-I      3'UTR chr6:42048129(+) A-I      3'UTR chr6:42048131(+) A-I      3'UTR chr6:42049019(+) A-I      3'UTR chr6:42048335(+) A-I      3'UTR chr6:42047535(+) A-I      3'UTR chr6:42047428(+) A-I      3'UTR chr6:42047400(+) A-I      3'UTR chr6:42047380(+) A-I      3'UTR chr6:42047365(+) A-I      3'UTR chr6:42046769(+) A-I      3'UTR chr6:42045897(+) A-I      3'UTR chr6:42045863(+) A-I      3'UTR chr6:42045647(+) A-I      3'UTR chr6:42045549(+) A-I      3'UTR chr6:42046766(+) A-I      3'UTR chr6:42045507(+) A-I      3'UTR chr6:42048147(+) A-I      3'UTR chr6:42046756(+) A-I      3'UTR chr6:42046745(+) A-I      3'UTR chr6:42046710(+) A-I      3'UTR chr6:42031084(+) A-I      ncRNA chr6:42031019(+) A-I      ncRNA chr6:42032084(+) A-I      intronic chr6:42021091(+) A-I      intronic chr6:42044108(+) A-I      intronic chr6:42021153(+) A-I      intronic chr6:42032207(+) A-I      intronic chr6:42030540(+) A-I      intronic chr6:42032091(+) A-I      intronic chr6:42033822(+) A-I      intronic chr6:42024360(+) A-I      intronic chr6:42030919(+) A-I      intronic chr6:42026849(+) A-I      intronic chr6:42032548(+) A-I      intronic chr6:42032108(+) A-I      intronic chr6:42025957(+) A-I      intronic chr6:42026867(+) A-I      intronic chr6:42031443(+) A-I      ncRNA chr6:42030922(+) A-I      intronic chr6:42030994(+) A-I      ncRNA chr6:42031633(+) A-I      intronic chr6:42030393(+) A-I      intronic chr6:42045790(+) A-I      3'UTR chr6:42048343(+) A-I      3'UTR chr6:42049381(+) A-I      3'UTR chr6:42048395(+) A-I      3'UTR chr6:42049425(+) A-I      3'UTR chr6:42050114(+) A-I      3'UTR chr6:42048211(+) A-I      3'UTR chr6:42046631(+) A-I      3'UTR chr6:42045594(+) A-I      3'UTR chr6:42048288(+) A-I      3'UTR chr6:42049015(+) A-I      3'UTR chr6:42047531(+) A-I      3'UTR chr6:42045758(+) A-I      3'UTR chr6:42045781(+) A-I      3'UTR chr6:42047320(+) A-I      3'UTR chr6:42047375(+) A-I      3'UTR chr6:42045703(+) A-I      3'UTR chr6:42045624(+) A-I      3'UTR chr6:42048141(+) A-I      3'UTR chr6:42049044(+) A-I      3'UTR chr6:42048311(+) A-I      3'UTR chr6:42047472(+) A-I      3'UTR chr6:42045668(+) A-I      3'UTR chr6:42045754(+) A-I      3'UTR chr6:42046862(+) A-I      3'UTR chr6:42050144(+) A-I      3'UTR chr6:42048361(+) A-I      3'UTR chr6:42050107(+) A-I      3'UTR chr6:42045803(+) A-I      3'UTR chr6:42047345(+) A-I      3'UTR chr6:42050179(+) A-I      3'UTR chr6:42046788(+) A-I      3'UTR chr6:42046674(+) A-I      3'UTR chr6:42047501(+) A-I      3'UTR chr6:42047387(+) A-I      3'UTR chr6:42045794(+) A-I      3'UTR chr6:42046740(+) A-I      3'UTR chr6:42045784(+) A-I      3'UTR chr6:42048276(+) A-I      3'UTR chr6:42045812(+) A-I      3'UTR chr6:42046708(+) A-I      3'UTR chr6:42047552(+) A-I      3'UTR chr6:42047514(+) A-I      3'UTR chr6:42047381(+) A-I      3'UTR chr6:42050345(+) A-I      3'UTR chr6:42047475(+) A-I      3'UTR chr6:42048136(+) A-I      3'UTR chr6:42048228(+) A-I      3'UTR chr6:42045890(+) A-I      3'UTR chr6:42049445(+) A-I      3'UTR chr6:42047553(+) A-I      3'UTR chr6:42049259(+) A-I      3'UTR chr6:42045563(+) A-I      3'UTR chr6:42047566(+) A-I      3'UTR chr6:42049518(+) A-I      3'UTR chr6:42046678(+) A-I      3'UTR chr6:42045674(+) A-I      3'UTR chr6:42048971(+) A-I      3'UTR chr6:42045545(+) A-I      3'UTR chr6:42046588(+) A-I      3'UTR chr6:42045733(+) A-I      3'UTR chr6:42050090(+) A-I      3'UTR chr6:42047492(+) A-I      3'UTR chr6:42045634(+) A-I      3'UTR chr6:42047324(+) A-I      3'UTR chr6:42048389(+) A-I      3'UTR chr6:42048314(+) A-I      3'UTR chr6:42048979(+) A-I      3'UTR chr6:42045683(+) A-I      3'UTR chr6:42048336(+) A-I      3'UTR chr6:42046749(+) A-I      3'UTR chr6:42048297(+) A-I      3'UTR chr6:42045729(+) A-I      3'UTR chr6:42045888(+) A-I      3'UTR chr6:42046604(+) A-I      3'UTR chr6:42045513(+) A-I      3'UTR chr6:42047527(+) A-I      3'UTR chr6:42047362(+) A-I      3'UTR chr6:42045755(+) A-I      3'UTR chr6:42050177(+) A-I      3'UTR chr6:42047554(+) A-I      3'UTR chr6:42046684(+) A-I      3'UTR chr6:42046866(+) A-I      3'UTR chr6:42046699(+) A-I      3'UTR chr6:42046842(+) A-I      3'UTR chr6:42045716(+) A-I      3'UTR chr6:42049107(+) A-I      3'UTR chr6:42047526(+) A-I      3'UTR chr6:42046695(+) A-I      3'UTR chr6:42046704(+) A-I      3'UTR chr6:42047354(+) A-I      3'UTR chr6:42048250(+) A-I      3'UTR chr6:42049314(+) A-I      3'UTR chr6:42045573(+) A-I      3'UTR chr6:42045595(+) A-I      3'UTR chr6:42047404(+) A-I      3'UTR chr6:42045677(+) A-I      3'UTR chr6:42046805(+) A-I      3'UTR chr6:42049016(+) A-I      3'UTR chr6:42030920(+) A-I      intronic chr6:42041791(+) A-I      intronic chr6:42021224(+) A-I      intronic chr6:42042472(+) A-I      intronic chr6:42021235(+) A-I      intronic chr6:42042543(+) A-I      intronic chr6:42044023(+) A-I      intronic chr6:42031512(+) A-I      intronic chr6:42044009(+) A-I      intronic chr6:42032193(+) A-I      intronic chr6:42032829(+) A-I      intronic chr6:42026059(+) A-I      intronic chr6:42019539(+) A-I      intronic chr6:42031597(+) A-I      intronic chr6:42025912(+) A-I      intronic chr6:42020904(+) A-I      intronic chr6:42032440(+) A-I      intronic chr6:42033901(+) A-I      intronic chr6:42024554(+) A-I      intronic chr6:42026093(+) A-I      intronic chr6:42041773(+) A-I      intronic chr6:42032122(+) A-I      intronic chr6:42025971(+) A-I      intronic chr6:42035010(+) A-I      intronic chr6:42026070(+) A-I      intronic chr6:42032441(+) A-I      intronic chr6:42032834(+) A-I      intronic chr6:42026001(+) A-I      intronic chr6:42041771(+) A-I      intronic chr6:42032213(+) A-I      intronic chr6:42030958(+) A-I      ncRNA chr6:42031415(+) A-I      ncRNA chr6:42031001(+) A-I      ncRNA chr6:42031485(+) A-I      ncRNA chr6:42031050(+) A-I      ncRNA chr6:42030970(+) A-I      ncRNA chr6:42031040(+) A-I      ncRNA chr6:42030978(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TAF8	chr6:42045530(+) A-I exon 3'UTR    15342557   //15258596 chr6:42045545(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr6:42045563(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr6:42045595(+) A-I exon 3'UTR    15342557   //15258596 chr6:42045668(+) A-I exon 3'UTR    15342557   //15258596 chr6:42045677(+) A-I exon 3'UTR    15342557   //15258596 chr6:42045683(+) A-I exon 3'UTR    15342557   //15258596 chr6:42045694(+) A-I exon 3'UTR    15342557   //15258596 chr6:42045703(+) A-I exon 3'UTR    15342557   //15258596 chr6:42045729(+) A-I exon 3'UTR    15342557   //15258596 chr6:42045733(+) A-I exon 3'UTR    15342557   //15258596 chr6:42045754(+) A-I exon 3'UTR    15342557   //15258596 chr6:42045790(+) A-I exon 3'UTR    15342557 chr6:42045803(+) A-I exon 3'UTR    15342557 chr6:42045809(+) A-I exon 3'UTR    15342557 chr6:42045819(+) A-I exon 3'UTR    15342557 chr6:42045838(+) A-I exon 3'UTR    15342557 chr6:42045888(+) A-I exon 3'UTR    15342557   //15258596 chr6:42045890(+) A-I exon 3'UTR    15342557   //15258596 chr6:42046026(+) A-I exon 3'UTR    15342557 chr6:42046588(+) A-I exon 3'UTR    15342557 chr6:42046605(+) A-I exon 3'UTR    15342557 chr6:42046631(+) A-I intron -    22327324 chr6:42047354(+) A-I intron -    21960545   //22327324 chr6:42047375(+) A-I intron -    22327324 chr6:42047426(+) A-I intron -    21960545   //22327324 chr6:42048348(+) A-I intron -    22327324 chr6:42047404(+) A-I intron -    21960545 chr6:42025416(+) A-G intron -    21725310   //22484847 chr6:42045563(+) A-G intron -    21725310   //22484847 chr6:42047527(+) A-G intron -    21725310   //22484847 chr6:42048167(+) A-G intron -    21725310 chr6:42048276(+) A-G intron -    21725310   //22484847 chr6:42024554(+) A-G intron -    22484847 chr6:42025396(+) A-G intron -    22484847 chr6:42025912(+) A-G intron -    22484847 chr6:42025957(+) A-G intron -    22484847 chr6:42025971(+) A-G intron -    22484847 chr6:42026001(+) A-G intron -    22484847 chr6:42026867(+) A-G intron -    22484847 chr6:42027000(+) A-G intron -    22484847 chr6:42030919(+) A-G intron -    22484847 chr6:42031013(+) A-G intron -    22484847 chr6:42031018(+) A-G intron -    22484847 chr6:42033901(+) A-G intron -    22484847 chr6:42042402(+) A-G intron -    22484847 chr6:42043992(+) T-C intron -    22484847 chr6:42045545(+) A-G intron -    22484847 chr6:42045595(+) A-G intron -    22484847 chr6:42045634(+) A-G intron -    22484847 chr6:42045673(+) G-T intron -    22484847 chr6:42045694(+) A-G intron -    22484847 chr6:42045809(+) A-G intron -    22484847 chr6:42045810(+) A-G intron -    22484847 chr6:42045819(+) A-G intron -    22484847 chr6:42045888(+) A-G intron -    22484847 chr6:42046588(+) A-G intron -    22484847 chr6:42046604(+) A-G intron -    22484847 chr6:42046610(+) A-G intron -    22484847 chr6:42046621(+) A-G intron -    22484847 chr6:42046631(+) A-G intron -    22484847 chr6:42046678(+) A-G intron -    22484847 chr6:42046684(+) A-G intron -    22484847 chr6:42046695(+) A-G intron -    22484847 chr6:42046780(+) A-G intron -    22484847 chr6:42047324(+) A-G intron -    22484847 chr6:42047345(+) A-G intron -    22484847 chr6:42047354(+) A-G intron -    22484847 chr6:42047362(+) A-G intron -    22484847 chr6:42047375(+) A-G intron -    22484847 chr6:42047387(+) A-G intron -    22484847 chr6:42047426(+) A-G intron -    22484847 chr6:42047492(+) A-G intron -    22484847 chr6:42047552(+) A-G intron -    22484847 chr6:42047553(+) A-G intron -    22484847 chr6:42047554(+) A-G intron -    22484847 chr6:42047566(+) A-G intron -    22484847 chr6:42048106(+) C-T intron -    22484847 chr6:42048111(+) C-T intron -    22484847 chr6:42048136(+) A-G intron -    22484847 chr6:42048141(+) A-G intron -    22484847 chr6:42048211(+) A-G intron -    22484847 chr6:42048240(+) A-G intron -    22484847 chr6:42048311(+) A-G intron -    22484847 chr6:42048348(+) A-G intron -    22484847 chr6:42048389(+) A-G intron -    22484847 chr6:42046582(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TAF8	chr6:42018274-42018275(+) m6A 5'UTR//exon       24284625//25456834//24981863 chr6:42018852-42018853(+) m6A 5'UTR//intron       24981863 chr6:42018875-42018876(+) m6A 5'UTR//intron       24981863 chr6:42019108-42019109(+) m6A 5'UTR//CDS//exon       24981863 chr6:42019154-42019155(+) m6A 5'UTR//CDS//exon       24981863 chr6:42025177-42025178(+) m6A CDS//exon       - chr6:42045406-42045407(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr6:42045424-42045425(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr6:42045480-42045481(+) m6A 3'UTR//intron       24981863//22608085 chr6:42045715-42045716(+) m6A 3'UTR//intron       24209618 chr6:42045850-42045851(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr6:42045931-42045932(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:42046016-42046017(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:42046025-42046026(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:42046083-42046084(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:42046165-42046166(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr6:42046254-42046255(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr6:42046458-42046459(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr6:42046535-42046536(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr6:42046562-42046563(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr6:42046660-42046661(+) m6A 3'UTR//intron       24209618//22608085 chr6:42046683-42046684(+) m6A 3'UTR//intron       24209618//22608085 chr6:42046780-42046781(+) m6A 3'UTR//intron       24209618 chr6:42046849-42046850(+) m6A 3'UTR//intron       24981863 chr6:42046885-42046886(+) m6A 3'UTR//intron       24981863 chr6:42047476-42047477(+) m6A 3'UTR//intron       24981863 chr6:42047513-42047514(+) m6A 3'UTR//intron       24981863//22608085 chr6:42047628-42047629(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr6:42047637-42047638(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr6:42047645-42047646(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr6:42047763-42047764(+) m6A 3'UTR//intron       24284625//25456834//24981863//22608085 chr6:42047800-42047801(+) m6A 3'UTR//intron       22608085 chr6:42047807-42047808(+) Tm 3'UTR//intron       - chr6:42047824-42047825(+) m6A 3'UTR//intron       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	TAF8	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: TAF8

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).