Basic Information:

  VIRBase ID:  

VHID00446922

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          DHRS1:  NM_138452     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	DHRS1
miRBase Accession/Entrez ID	MIMAT0002186	115817
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	SDR19C1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DHRS1	chr14:24767508(-) A-I      intronic chr14:24768455(-) A-I      5'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DHRS1	chr14:24765994-24765995(-) m6A CDS//exon       27773535 chr14:24767961-24767962(-) m6A exon//intron       27773535 chr14:24768653-24768654(-) m6A 5'UTR//intron       24981863 chr14:24768810-24768811(-) m6A 5'UTR//exon       24284625//24981863 chr14:24768838-24768839(-) m6A 5'UTR//exon       24284625//24981863 chr14:24768844-24768845(-) m6A 5'UTR//exon       24284625//24981863 chr14:24768881-24768882(-) m6A 5'UTR//exon       24284625//24981863 chr14:24768942-24768943(-) m6A 5'UTR//exon       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	DHRS1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: DHRS1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).