Basic Information:

  VIRBase ID:  

VHID00446913

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          CMTM7:  NM_181472     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	CMTM7
miRBase Accession/Entrez ID	MIMAT0002186	112616
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CKLFSF7

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CMTM7	chr3:32442126(+) A-I      intronic chr3:32440220(+) A-I      intronic chr3:32440221(+) A-I      intronic chr3:32440343(+) A-I      intronic chr3:32440356(+) A-I      intronic chr3:32440362(+) A-I      intronic chr3:32481135(+) A-I      intronic chr3:32494683(+) A-I      intronic chr3:32440366(+) A-I      intronic chr3:32453900(+) A-I      intronic chr3:32453715(+) A-I      intronic chr3:32444852(+) A-I      intronic chr3:32444248(+) A-I      intronic chr3:32444225(+) A-I      intronic chr3:32481085(+) A-I      intronic chr3:32481087(+) A-I      intronic chr3:32481107(+) A-I      intronic chr3:32481093(+) A-I      intronic chr3:32475561(+) A-I      intronic chr3:32484684(+) A-I      intronic chr3:32484703(+) A-I      intronic chr3:32491797(+) A-I      intronic chr3:32491793(+) A-I      intronic chr3:32484639(+) A-I      intronic chr3:32494264(+) A-I      intronic chr3:32494677(+) A-I      intronic chr3:32480955(+) A-I      intronic chr3:32440321(+) A-I      intronic chr3:32494343(+) A-I      intronic chr3:32494705(+) A-I      intronic chr3:32444188(+) A-I      intronic chr3:32467383(+) A-I      intronic chr3:32481670(+) A-I      intronic chr3:32475494(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CMTM7	chr3:32433194-32433195(+) m6A 5'UTR       24981863 chr3:32433285-32433286(+) m6A 5'UTR       24981863 chr3:32433454-32433455(+) m6A CDS       24981863 chr3:32495930-32495931(+) m6A 3'UTR//CDS//exon       25456834 chr3:32495956-32495957(+) m6A 3'UTR//CDS//exon       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	CMTM7	Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: CMTM7

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.