Basic Information:

  VIRBase ID:  

VHID00446902

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          ZNF551:  NM_138347     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	ZNF551
miRBase Accession/Entrez ID	MIMAT0002186	90233
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF551	chr19:58197863(+) A-I intron -    21960545 chr19:58197942(+) A-I intron -    21960545 chr19:58197943(+) A-I intron -    21960545 chr19:58198308(+) A-I intron -    21960545 chr19:58200282(+) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF551	chr19:58193442-58193443(+) m6A 5'UTR//exon       - chr19:58193517-58193518(+) m6A 5'UTR//exon//intron       - chr19:58197913-58197914(+) m6A CDS//exon//intron       24981863//22608085 chr19:58197943-58197944(+) m6A CDS//exon//intron       24981863//22608085 chr19:58197986-58197987(+) m6A CDS//exon//intron       24981863//22608085 chr19:58198012-58198013(+) m6A CDS//exon//intron       24981863//22608085 chr19:58198433-58198434(+) m6A CDS//intron       22608085 chr19:58198467-58198468(+) m6A CDS//intron       22608085 chr19:58198669-58198670(+) m6A CDS//intron       22608085 chr19:58198698-58198699(+) m6A CDS//intron       22608085 chr19:58198761-58198762(+) m6A CDS//intron       24981863//22608085 chr19:58198845-58198846(+) m6A CDS//intron       24209618//24981863//22608085 chr19:58198941-58198942(+) m6A CDS//intron       24209618//25456834//24981863//22608085 chr19:58198977-58198978(+) m6A CDS//intron       25456834//24981863//22608085 chr19:58199013-58199014(+) m6A CDS//intron       24209618//25456834//24981863//22608085 chr19:58199145-58199146(+) m6A CDS//intron       24209618//25456834//24981863//22608085 chr19:58199229-58199230(+) m6A CDS//intron       24209618//25456834//24981863//22608085 chr19:58199265-58199266(+) m6A CDS//intron       24209618//25456834//24981863//22608085 chr19:58199295-58199296(+) m6A CDS//intron       24209618//25456834//24981863//22608085 chr19:58199481-58199482(+) m6A CDS//intron       24209618//24981863//22608085 chr19:58199508-58199509(+) m6A CDS//intron       24209618//24981863//22608085 chr19:58199528-58199529(+) m6A CDS//intron       24209618//24981863//22608085 chr19:58199707-58199708(+) m6A 3'UTR//intron       24981863//22608085 chr19:58199735-58199736(+) m6A 3'UTR//intron       24981863 chr19:58199950-58199951(+) m6A 3'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	ZNF551	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: ZNF551

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).