Basic Information:

  VIRBase ID:  

VHID00446896

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          KLHL6:  NM_130446     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	KLHL6
miRBase Accession/Entrez ID	MIMAT0002186	89857
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KLHL6	chr3:183240760(-) A-I      ncRNA chr3:183240757(-) A-I      ncRNA chr3:183240717(-) A-I      ncRNA chr3:183240796(-) A-I      ncRNA chr3:183240886(-) A-I      ncRNA chr3:183240676(-) A-I      ncRNA chr3:183221520(-) A-I      intronic chr3:183224371(-) A-I      intronic chr3:183224516(-) A-I      intronic chr3:183225417(-) A-I      intronic chr3:183225424(-) A-I      intronic chr3:183225449(-) A-I      intronic chr3:183228605(-) A-I      intronic chr3:183233260(-) A-I      intronic chr3:183233314(-) A-I      intronic chr3:183233330(-) A-I      intronic chr3:183234794(-) A-I      intronic chr3:183234835(-) A-I      intronic chr3:183234981(-) A-I      intronic chr3:183241672(-) A-I      intronic chr3:183241680(-) A-I      intronic chr3:183244824(-) A-I      intronic chr3:183241828(-) A-I      intronic chr3:183243851(-) A-I      intronic chr3:183243950(-) A-I      intronic chr3:183243961(-) A-I      intronic chr3:183243977(-) A-I      intronic chr3:183244012(-) A-I      intronic chr3:183244624(-) A-I      intronic chr3:183244630(-) A-I      intronic chr3:183244642(-) A-I      intronic chr3:183244669(-) A-I      intronic chr3:183244825(-) A-I      intronic chr3:183244853(-) A-I      intronic chr3:183241822(-) A-I      intronic chr3:183241821(-) A-I      intronic chr3:183244765(-) A-I      intronic chr3:183244748(-) A-I      intronic chr3:183241722(-) A-I      intronic chr3:183216962(-) A-I      intronic chr3:183241686(-) A-I      intronic chr3:183244779(-) A-I      intronic chr3:183264919(-) A-I      intronic chr3:183264928(-) A-I      intronic chr3:183247409(-) A-I      intronic chr3:183244778(-) A-I      intronic chr3:183247511(-) A-I      intronic chr3:183258435(-) A-I      intronic chr3:183241685(-) A-I      intronic chr3:183247435(-) A-I      intronic chr3:183221398(-) A-I      intronic chr3:183221491(-) A-I      intronic chr3:183221504(-) A-I      intronic chr3:183248802(-) A-I      intronic chr3:183253661(-) A-I      intronic chr3:183253702(-) A-I      intronic chr3:183253841(-) A-I      intronic chr3:183253851(-) A-I      intronic chr3:183257375(-) A-I      intronic chr3:183257456(-) A-I      intronic chr3:183257475(-) A-I      intronic chr3:183244805(-) A-I      intronic chr3:183209075(-) A-I      3'UTR chr3:183209077(-) A-I      3'UTR chr3:183240682(-) A-I      ncRNA chr3:183239558(-) A-I      ncRNA chr3:183240686(-) A-I      ncRNA chr3:183239992(-) A-I      intronic chr3:183249525(-) A-I      intronic chr3:183247438(-) A-I      intronic chr3:183241776(-) A-I      intronic chr3:183247521(-) A-I      intronic chr3:183239990(-) A-I      intronic chr3:183234793(-) A-I      intronic chr3:183264824(-) A-I      intronic chr3:183233163(-) A-I      intronic chr3:183221528(-) A-I      intronic chr3:183224521(-) A-I      intronic chr3:183208410(-) A-I      3'UTR chr3:183209080(-) A-I      3'UTR chr3:183209009(-) A-I      3'UTR chr3:183209104(-) A-I      3'UTR chr3:183208388(-) A-I      3'UTR chr3:183208430(-) A-I      3'UTR chr3:183208427(-) A-I      3'UTR chr3:183208567(-) A-I      3'UTR chr3:183208511(-) A-I      3'UTR chr3:183208458(-) A-I      3'UTR chr3:183209035(-) A-I      3'UTR chr3:183208469(-) A-I      3'UTR chr3:183208987(-) A-I      3'UTR chr3:183208995(-) A-I      3'UTR chr3:183209062(-) A-I      3'UTR chr3:183208465(-) A-I      3'UTR chr3:183209067(-) A-I      3'UTR chr3:183209068(-) A-I      3'UTR chr3:183209026(-) A-I      3'UTR chr3:183209052(-) A-I      3'UTR chr3:183208350(-) A-I      3'UTR chr3:183209046(-) A-I      3'UTR chr3:183209022(-) A-I      3'UTR chr3:183208436(-) A-I      3'UTR chr3:183208445(-) A-I      3'UTR chr3:183208493(-) A-I      3'UTR chr3:183209071(-) A-I      3'UTR chr3:183208510(-) A-I      3'UTR chr3:183209066(-) A-I      3'UTR chr3:183208994(-) A-I      3'UTR chr3:183209096(-) A-I      3'UTR chr3:183209174(-) A-I      3'UTR chr3:183209036(-) A-I      3'UTR chr3:183208444(-) A-I      3'UTR chr3:183209119(-) A-I      3'UTR chr3:183208484(-) A-I      3'UTR chr3:183248717(-) A-I      intronic chr3:183224540(-) A-I      intronic chr3:183221455(-) A-I      intronic chr3:183234764(-) A-I      intronic chr3:183239774(-) A-I      intronic chr3:183244016(-) A-I      intronic chr3:183244063(-) A-I      intronic chr3:183247450(-) A-I      intronic chr3:183228406(-) A-I      intronic chr3:183247546(-) A-I      intronic chr3:183224492(-) A-I      intronic chr3:183252205(-) A-I      intronic chr3:183249373(-) A-I      intronic chr3:183239957(-) A-I      intronic chr3:183233250(-) A-I      intronic chr3:183225348(-) A-I      intronic chr3:183244775(-) A-I      intronic chr3:183258448(-) A-I      intronic chr3:183247526(-) A-I      intronic chr3:183247408(-) A-I      intronic chr3:183225387(-) A-I      intronic chr3:183224443(-) A-I      intronic chr3:183225327(-) A-I      intronic chr3:183257483(-) A-I      intronic chr3:183240108(-) A-I      ncRNA chr3:183240664(-) A-I      ncRNA chr3:183239567(-) A-I      ncRNA chr3:183240766(-) A-I      ncRNA chr3:183239544(-) A-I      ncRNA chr3:183239542(-) A-I      ncRNA chr3:183240769(-) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KLHL6	chr3:183209022(-) A-I exon 3'UTR    15258596 chr3:183209035(-) A-I exon 3'UTR    15258596 chr3:183209052(-) A-I exon 3'UTR    15258596 chr3:183209062(-) A-I exon 3'UTR    15258596 chr3:183208511(-) A-I exon 3'UTR    22327324 chr3:183209026(-) A-G exon 3'UTR    21725310   //22484847 chr3:183208388(-) A-G exon 3'UTR    22484847 chr3:183208413(-) A-G exon 3'UTR    22484847 chr3:183208444(-) A-G exon 3'UTR    22484847 chr3:183208445(-) A-G exon 3'UTR    22484847 chr3:183208465(-) A-G exon 3'UTR    22484847 chr3:183208471(-) A-G exon 3'UTR    22484847 chr3:183208481(-) A-G exon 3'UTR    22484847 chr3:183208506(-) A-G exon 3'UTR    22484847 chr3:183208510(-) A-G exon 3'UTR    22484847 chr3:183208511(-) A-G exon 3'UTR    22484847 chr3:183208902(-) A-C exon 3'UTR    22484847 chr3:183208904(-) A-T exon 3'UTR    22484847 chr3:183208995(-) A-G exon 3'UTR    22484847 chr3:183209022(-) A-G exon 3'UTR    22484847 chr3:183209030(-) A-G exon 3'UTR    22484847 chr3:183209036(-) A-G exon 3'UTR    22484847 chr3:183209052(-) A-G exon 3'UTR    22484847 chr3:183209062(-) A-G exon 3'UTR    22484847 chr3:183209065(-) A-G exon 3'UTR    22484847 chr3:183209066(-) A-G exon 3'UTR    22484847 chr3:183209068(-) A-G exon 3'UTR    22484847 chr3:183209128(-) A-G exon 3'UTR    22484847 chr3:183209173(-) A-G exon 3'UTR    22484847 chr3:183221402(-) A-G intron -    22484847 chr3:183221587(-) A-G intron -    22484847 chr3:183224365(-) A-G intron -    22484847 chr3:183224443(-) A-G intron -    22484847 chr3:183224540(-) A-G intron -    22484847 chr3:183225327(-) A-G intron -    22484847 chr3:183225348(-) A-G intron -    22484847 chr3:183225358(-) A-G intron -    22484847 chr3:183233163(-) A-G intron -    22484847 chr3:183233250(-) A-G intron -    22484847 chr3:183233300(-) A-G intron -    22484847 chr3:183233305(-) A-G intron -    22484847 chr3:183239957(-) A-G intron -    22484847 chr3:183239986(-) A-G intron -    22484847 chr3:183239990(-) A-G intron -    22484847 chr3:183239992(-) A-G intron -    22484847 chr3:183240664(-) A-G intron -    22484847 chr3:183240686(-) A-G intron -    22484847 chr3:183240765(-) G-C intron -    22484847 chr3:183240766(-) A-G intron -    22484847 chr3:183241728(-) A-G intron -    22484847 chr3:183241776(-) A-G intron -    22484847 chr3:183244016(-) A-G intron -    22484847 chr3:183244080(-) G-A intron -    22484847 chr3:183247408(-) A-G intron -    22484847 chr3:183247438(-) A-G intron -    22484847 chr3:183247452(-) A-G intron -    22484847 chr3:183247521(-) A-G intron -    22484847 chr3:183247526(-) A-G intron -    22484847 chr3:183247529(-) A-G intron -    22484847 chr3:183247546(-) A-G intron -    22484847 chr3:183257483(-) A-G intron -    22484847 chr3:183257510(-) T-G intron -    22484847 chr3:183258419(-) A-G intron -    22484847 chr3:183258424(-) A-G intron -    22484847 chr3:183264824(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KLHL6	chr3:183206320-183206321(-) m6A 3'UTR       27371828 chr3:183206343-183206344(-) m6A 3'UTR       27371828 chr3:183206350-183206351(-) m6A 3'UTR       27371828 chr3:183206377-183206378(-) m6A 3'UTR       27371828 chr3:183206388-183206389(-) m6A 3'UTR       27371828 chr3:183206396-183206397(-) m6A 3'UTR       27371828 chr3:183206403-183206404(-) m6A 3'UTR       27371828 chr3:183206411-183206412(-) m6A 3'UTR       27371828 chr3:183207787-183207788(-) m6A 3'UTR       - chr3:183207867-183207868(-) m6A 3'UTR       - chr3:183207948-183207949(-) m6A 3'UTR       - chr3:183208009-183208010(-) m6A 3'UTR       - chr3:183208136-183208137(-) m6A 3'UTR       - chr3:183208160-183208161(-) m6A 3'UTR       - chr3:183208166-183208167(-) m6A 3'UTR       - chr3:183208183-183208184(-) m6A 3'UTR       - chr3:183208877-183208878(-) m6A 3'UTR//exon//intron       27371828 chr3:183208885-183208886(-) m6A 3'UTR//exon//intron       27371828 chr3:183208891-183208892(-) m6A 3'UTR//exon//intron       27371828 chr3:183208897-183208898(-) m6A 3'UTR//exon//intron       27371828 chr3:183208903-183208904(-) m6A 3'UTR//exon//intron       27371828 chr3:183208909-183208910(-) m6A 3'UTR//exon//intron       27371828 chr3:183208934-183208935(-) m6A 3'UTR//exon//intron       27371828 chr3:183208993-183208994(-) m6A 3'UTR//exon//intron       27371828 chr3:183209209-183209210(-) m6A 3'UTR//exon       - chr3:183209220-183209221(-) m6A 3'UTR//exon       - chr3:183209231-183209232(-) m6A 3'UTR//exon       - chr3:183209370-183209371(-) m6A 3'UTR//exon       - chr3:183209471-183209472(-) m6A 3'UTR//exon       27371828 chr3:183209541-183209542(-) m6A 3'UTR//exon       28052920//27371828 chr3:183209573-183209574(-) m6A 3'UTR//exon       28052920//27371828 chr3:183209825-183209826(-) m6A CDS//exon       28052920//27371828 chr3:183209841-183209842(-) m6A CDS//exon       28052920//27371828 chr3:183209973-183209974(-) m6A CDS//exon       27371828 chr3:183226043-183226044(-) m6A CDS//exon       - chr3:183226108-183226109(-) m6A CDS//exon       27371828 chr3:183226138-183226139(-) m6A CDS//exon       27371828 chr3:183226156-183226157(-) m6A CDS//exon       27371828 chr3:183226195-183226196(-) m6A CDS//exon       27371828 chr3:183226237-183226238(-) m6A CDS//exon       27371828 chr3:183226246-183226247(-) m6A CDS//exon       27371828 chr3:183239112-183239113(-) m6A exon//intron       - chr3:183239157-183239158(-) m6A exon//intron       - chr3:183239180-183239181(-) m6A exon//intron       - chr3:183239216-183239217(-) m6A exon//intron       - chr3:183240368-183240369(-) m6A exon//intron       - chr3:183240374-183240375(-) m6A exon//intron       - chr3:183240574-183240575(-) m6A exon//intron       - chr3:183240584-183240585(-) m6A exon//intron       - chr3:183240591-183240592(-) m6A exon//intron       - chr3:183240599-183240600(-) m6A exon//intron       - chr3:183240607-183240608(-) m6A exon//intron       - chr3:183240612-183240613(-) m6A exon//intron       - chr3:183240618-183240619(-) m6A exon//intron       - chr3:183240631-183240632(-) m6A exon//intron       - chr3:183240699-183240700(-) m6A exon//intron       - chr3:183273251-183273252(-) m6A CDS//exon       27371828 chr3:183273282-183273283(-) m6A CDS//exon       27371828 chr3:183273331-183273332(-) m6A CDS//exon       27371828 chr3:183273338-183273339(-) m6A CDS//exon       27371828 chr3:183273410-183273411(-) m6A CDS//exon       27371828 chr3:183273426-183273427(-) m6A CDS//exon       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	KLHL6	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: KLHL6

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells//EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).