Basic Information:

  VIRBase ID:  

VHID00446791

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          CBX8:  NM_020649     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	CBX8
miRBase Accession/Entrez ID	MIMAT0002186	57332
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PC3//RC1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CBX8	chr17:77766944-77766945(-) m6A 3'UTR       27371828 chr17:77767152-77767153(-) m6A 3'UTR       27773536 chr17:77767227-77767228(-) m6A 3'UTR       27371828//27773536//22608085 chr17:77767258-77767259(-) m6A 3'UTR       27371828//27773536//22608085 chr17:77767351-77767352(-) m6A 3'UTR       24981863//27371828//27773536//22608085 chr17:77767369-77767370(-) m6A 3'UTR       24981863//27371828//27773536//22608085 chr17:77767381-77767382(-) m6A 3'UTR       25456834//24981863//27371828//27773536//22608085 chr17:77767427-77767428(-) m6A 3'UTR       24981863//27371828//27773536//22608085 chr17:77767499-77767500(-) m6A 3'UTR       24981863//27371828 chr17:77768151-77768152(-) m6A 3'UTR       27773535 chr17:77768461-77768462(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:77768497-77768498(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:77768569-77768570(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:77768635-77768636(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr17:77768770-77768771(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr17:77768781-77768782(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr17:77768833-77768834(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr17:77768839-77768840(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr17:77768844-77768845(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr17:77768952-77768953(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr17:77768977-77768978(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr17:77769022-77769023(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:77769133-77769134(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:77769145-77769146(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:77769151-77769152(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:77769157-77769158(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:77769226-77769227(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536//22608085 chr17:77769265-77769266(-) m6A CDS//exon       24284625//24981863//27773535//27371828//27773536//22608085 chr17:77769332-77769333(-) m6A CDS//exon       24284625//24981863//27773535//27371828//27773536 chr17:77769869-77769870(-) m6A CDS//exon       24284625//24981863//27773535//27371828//27773536 chr17:77769882-77769883(-) m6A CDS//exon       24284625//24981863//27773535//27371828//27773536 chr17:77770087-77770088(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828 chr17:77770098-77770099(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828 chr17:77770890-77770891(-) m6A 5'UTR//intron       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	CBX8	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: CBX8

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.