Basic Information:

  VIRBase ID:  

VHID00446643

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          GSE1:  NM_001278184     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	GSE1
miRBase Accession/Entrez ID	MIMAT0002186	23199
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CRHSP24//KIAA0182

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GSE1	chr16:85705731(+) A-I      ncRNA chr16:85705744(+) A-I      ncRNA chr16:85705770(+) A-I      intronic chr16:85705668(+) A-I      ncRNA chr16:85705649(+) A-I      ncRNA chr16:85705624(+) A-I      ncRNA chr16:85652349(+) A-I      intronic chr16:85652531(+) A-I      intronic chr16:85656840(+) A-I      intronic chr16:85656891(+) A-I      intronic chr16:85656906(+) A-I      intronic chr16:85693969(+) A-I      intronic chr16:85693996(+) A-I      intronic chr16:85694114(+) A-I      intronic chr16:85694354(+) A-I      intronic chr16:85694423(+) A-I      intronic chr16:85694498(+) A-I      intronic chr16:85705154(+) A-I      intronic chr16:85652490(+) A-I      intronic chr16:85652530(+) A-I      intronic chr16:85705705(+) A-I      ncRNA chr16:85694366(+) A-I      intronic chr16:85694009(+) A-I      intronic chr16:85694042(+) A-I      intronic chr16:85694033(+) A-I      intronic chr16:85664053(+) A-I      intronic chr16:85694036(+) A-I      intronic chr16:85694510(+) A-I      intronic chr16:85705636(+) A-I      ncRNA chr16:85705175(+) A-I      intronic chr16:85694148(+) A-I      intronic chr16:85694125(+) A-I      intronic chr16:85694458(+) A-I      intronic chr16:85694056(+) A-I      intronic chr16:85705207(+) A-I      intronic chr16:85693988(+) A-I      intronic chr16:85705096(+) A-I      intronic chr16:85694418(+) A-I      intronic chr16:85694421(+) A-I      intronic chr16:85705103(+) A-I      intronic chr16:85694165(+) A-I      intronic chr16:85694337(+) A-I      intronic chr16:85694336(+) A-I      intronic chr16:85694067(+) A-I      intronic chr16:85705656(+) A-I      ncRNA chr16:85705135(+) A-I      intronic chr16:85705734(+) A-I      ncRNA chr16:85705644(+) A-I      ncRNA chr16:85694166(+) A-I      intronic chr16:85652522(+) A-I      intronic chr16:85694081(+) A-I      intronic chr16:85704844(+) A-I      intronic chr16:85694376(+) A-I      intronic chr16:85705722(+) A-I      ncRNA chr16:85694157(+) A-I      intronic chr16:85693987(+) A-I      intronic chr16:85705177(+) A-I      intronic chr16:85705102(+) A-I      intronic chr16:85664020(+) A-I      intronic chr16:85705140(+) A-I      intronic chr16:85694340(+) A-I      intronic chr16:85693455(+) A-I      intronic chr16:85694173(+) A-I      intronic chr16:85694057(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GSE1	chr16:85646934-85646935(+) m6A 5'UTR//intron       24284625//24981863 chr16:85667575-85667576(+) m6A CDS//intron       24284625//24981863 chr16:85667718-85667719(+) m6A CDS//intron       24284625 chr16:85682321-85682322(+) m6A CDS       24284625 chr16:85687963-85687964(+) m6A CDS       24284625 chr16:85688449-85688450(+) m6A CDS       24284625 chr16:85688524-85688525(+) m6A CDS       24284625 chr16:85691098-85691099(+) m6A CDS       - chr16:85691189-85691190(+) Cm CDS       - chr16:85694757-85694758(+) m6A CDS       24284625//25456834//24981863//22608085 chr16:85694762-85694763(+) m6A CDS       24284625//25456834//24981863//22608085 chr16:85694867-85694868(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr16:85694885-85694886(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr16:85695050-85695051(+) m6A CDS       24284625//25456834//24981863//22575960 chr16:85695160-85695161(+) m6A CDS//exon       24284625 chr16:85695222-85695223(+) m6A CDS//exon       24284625 chr16:85695332-85695333(+) m6A CDS//exon       24284625 chr16:85695980-85695981(+) m6A exon//intron       24284625 chr16:85696416-85696417(+) m6A exon//intron       24284625 chr16:85696453-85696454(+) m6A exon//intron       24284625 chr16:85696538-85696539(+) m6A exon//intron       24284625 chr16:85696680-85696681(+) m6A CDS//exon       24284625 chr16:85696685-85696686(+) m6A CDS//exon       24284625 chr16:85696722-85696723(+) m6A exon//intron       24284625 chr16:85696868-85696869(+) m6A exon//intron       24284625 chr16:85696881-85696882(+) m6A exon//intron       24284625 chr16:85696889-85696890(+) m6A exon//intron       24284625 chr16:85696922-85696923(+) m6A exon//intron       - chr16:85698698-85698699(+) m6A CDS//exon//intron       24284625 chr16:85698710-85698711(+) m6A CDS//exon//intron       24284625 chr16:85699681-85699682(+) m6A CDS//exon       24284625 chr16:85699818-85699819(+) m6A CDS//exon       24284625//24209618//24981863//22575960 chr16:85700063-85700064(+) m6A exon//intron       - chr16:85701775-85701776(+) m6A CDS//exon       24284625 chr16:85701907-85701908(+) m6A CDS//exon       24284625//25456834//24981863 chr16:85701913-85701914(+) m6A CDS//exon       24284625//25456834//24981863 chr16:85702019-85702020(+) m6A CDS//exon       24284625//24209618//25456834//24981863 chr16:85704284-85704285(+) m6A exon//intron       24284625//24209618 chr16:85704629-85704630(+) m6A CDS//exon       24284625//24209618 chr16:85705520-85705521(+) m6A exon//intron       24284625//24981863//27773535 chr16:85705539-85705540(+) m6A exon//intron       24284625//24981863//27773535 chr16:85705564-85705565(+) m6A exon//intron       27773535 chr16:85705903-85705904(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr16:85706027-85706028(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22608085 chr16:85706066-85706067(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22608085 chr16:85706071-85706072(+) m6A 3'UTR//CDS//exon       24284625//25456834//24981863//22608085 chr16:85706168-85706169(+) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//22608085 chr16:85706303-85706304(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:85706432-85706433(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr16:85706460-85706461(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr16:85706501-85706502(+) m6A 3'UTR//exon       24284625 chr16:85706951-85706952(+) m6A 3'UTR//exon       27773535 chr16:85707099-85707100(+) m6A 3'UTR//exon       27773535 chr16:85707135-85707136(+) m6A 3'UTR//exon       27773535 chr16:85707842-85707843(+) m6A 3'UTR//exon       27773536 chr16:85708008-85708009(+) m6A 3'UTR//exon       25456834//24981863//22608085 chr16:85708044-85708045(+) m6A 3'UTR//exon       25456834//24981863//22608085 chr16:85708095-85708096(+) m6A 3'UTR//exon       25456834//24981863//22608085 chr16:85708134-85708135(+) m6A 3'UTR//exon       24981863 chr16:85708348-85708349(+) m6A 3'UTR//exon       - chr16:85708553-85708554(+) m6A 3'UTR//exon       24981863 chr16:85708575-85708576(+) m6A 3'UTR//exon       24981863 chr16:85708593-85708594(+) m6A 3'UTR//exon       24981863 chr16:85708625-85708626(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	GSE1	Chromatin K562 cells     - Cytoplasm Cell line (HeLa)     22319583 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Cell line (HeLa)     22319583 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: GSE1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).