Basic Information:

  VIRBase ID:  

VHID00446603

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          TSPAN9:  NM_006675     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	TSPAN9
miRBase Accession/Entrez ID	MIMAT0002186	10867
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	NET-5//NET5//PP1057

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TSPAN9	chr12:3218817(+) A-I      intronic chr12:3218807(+) A-I      intronic chr12:3218798(+) A-I      intronic chr12:3218802(+) A-I      intronic chr12:3386070(+) A-I      intronic chr12:3218843(+) A-I      intronic chr12:3218844(+) A-I      intronic chr12:3218833(+) A-I      intronic chr12:3218825(+) A-I      intronic chr12:3287371(+) A-I      intronic chr12:3293387(+) A-I      intronic chr12:3267678(+) A-I      intronic chr12:3318294(+) A-I      intronic chr12:3293399(+) A-I      intronic chr12:3318350(+) A-I      intronic chr12:3335736(+) A-I      intronic chr12:3267687(+) A-I      intronic chr12:3268808(+) A-I      intronic chr12:3267692(+) A-I      intronic chr12:3267863(+) A-I      intronic chr12:3319004(+) A-I      intronic chr12:3188728(+) A-I      intronic chr12:3233850(+) A-I      intronic chr12:3318358(+) A-I      intronic chr12:3289458(+) A-I      intronic chr12:3234033(+) A-I      intronic chr12:3293404(+) A-I      intronic chr12:3234042(+) A-I      intronic chr12:3318351(+) A-I      intronic chr12:3293405(+) A-I      intronic chr12:3235935(+) A-I      intronic chr12:3235949(+) A-I      intronic chr12:3266335(+) A-I      intronic chr12:3266474(+) A-I      intronic chr12:3267652(+) A-I      intronic chr12:3265839(+) A-I      intronic chr12:3293467(+) A-I      intronic chr12:3318322(+) A-I      intronic chr12:3198951(+) A-I      intronic chr12:3268854(+) A-I      intronic chr12:3198236(+) A-I      intronic chr12:3319246(+) A-I      intronic chr12:3319208(+) A-I      intronic chr12:3335738(+) A-I      intronic chr12:3330618(+) A-I      intronic chr12:3203225(+) A-I      intronic chr12:3303743(+) A-I      intronic chr12:3268807(+) A-I      intronic chr12:3289510(+) A-I      intronic chr12:3329143(+) A-I      intronic chr12:3329212(+) A-I      intronic chr12:3293443(+) A-I      intronic chr12:3329144(+) A-I      intronic chr12:3270293(+) A-I      intronic chr12:3329190(+) A-I      intronic chr12:3221949(+) A-I      intronic chr12:3329213(+) A-I      intronic chr12:3268804(+) A-I      intronic chr12:3319187(+) A-I      intronic chr12:3330642(+) A-I      intronic chr12:3211681(+) A-I      intronic chr12:3268818(+) A-I      intronic chr12:3303742(+) A-I      intronic chr12:3198567(+) A-I      intronic chr12:3318147(+) A-I      intronic chr12:3293449(+) A-I      intronic chr12:3293493(+) A-I      intronic chr12:3330947(+) A-I      intronic chr12:3265857(+) A-I      intronic chr12:3319941(+) A-I      intronic chr12:3265926(+) A-I      intronic chr12:3331076(+) A-I      intronic chr12:3318148(+) A-I      intronic chr12:3268769(+) A-I      intronic chr12:3344212(+) A-I      intronic chr12:3189684(+) A-I      intronic chr12:3329246(+) A-I      intronic chr12:3327946(+) A-I      intronic chr12:3188757(+) A-I      intronic chr12:3328101(+) A-I      intronic chr12:3319181(+) A-I      intronic chr12:3329145(+) A-I      intronic chr12:3344222(+) A-I      intronic chr12:3198238(+) A-I      intronic chr12:3196559(+) A-I      intronic chr12:3329135(+) A-I      intronic chr12:3233678(+) A-I      intronic chr12:3394456(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TSPAN9	chr12:3327471(+) A-I intron -    15342557 chr12:3327548(+) A-I intron -    15342557 chr12:3327805(+) A-I intron -    15342557 chr12:3327946(+) A-I intron -    15342557 chr12:3328101(+) A-I intron -    15342557 chr12:3329135(+) A-I intron -    15342557 chr12:3329143(+) A-I intron -    15342557 chr12:3329144(+) A-I intron -    15342557 chr12:3329145(+) A-I intron -    15342557 chr12:3329212(+) A-I intron -    15342557 chr12:3329213(+) A-I intron -    15342557 chr12:3329246(+) A-I intron -    15342557

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TSPAN9	chr12:3387758-3387759(+) m6A 3'UTR//CDS//exon       24284625 chr12:3388227-3388228(+) m6A CDS//exon       24284625//24981863 chr12:3389569-3389570(+) m6A CDS//exon       24284625//24981863 chr12:3389605-3389606(+) m6A CDS//exon       24284625//24981863 chr12:3389632-3389633(+) m6A CDS//exon       24284625//24981863 chr12:3390394-3390395(+) m6A CDS//exon       24284625 chr12:3390418-3390419(+) m6A CDS//exon       24284625 chr12:3392258-3392259(+) m6A CDS       24284625//24209618 chr12:3392432-3392433(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:3392476-3392477(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:3392564-3392565(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr12:3392939-3392940(+) m6A 3'UTR       25456834 chr12:3392962-3392963(+) m6A 3'UTR       24209618//25456834 chr12:3393044-3393045(+) m6A 3'UTR       24209618//25456834 chr12:3393049-3393050(+) m6A 3'UTR       24209618//25456834 chr12:3393056-3393057(+) m6A 3'UTR       24209618//25456834 chr12:3393081-3393082(+) m6A 3'UTR       24209618//25456834 chr12:3393225-3393226(+) m6A 3'UTR       24209618 chr12:3393607-3393608(+) m6A 3'UTR       24209618 chr12:3393671-3393672(+) m6A 3'UTR       24209618//24981863 chr12:3393687-3393688(+) m6A 3'UTR       24209618//24981863 chr12:3393821-3393822(+) m6A 3'UTR       25456834 chr12:3394211-3394212(+) m6A 3'UTR       - chr12:3394325-3394326(+) m6A 3'UTR       - chr12:3394352-3394353(+) m6A 3'UTR       - chr12:3394370-3394371(+) m6A 3'UTR       - chr12:3394379-3394380(+) m6A 3'UTR       - chr12:3394404-3394405(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	TSPAN9	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: TSPAN9

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).