Basic Information:

  VIRBase ID:  

VHID00446511

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          APOL1:  NM_001136540     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	APOL1
miRBase Accession/Entrez ID	MIMAT0002186	8542
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	APO-L//APOL//APOL-I//FSGS4

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	APOL1	chr22:36662289(+) A-I      3'UTR chr22:36662292(+) A-I      3'UTR chr22:36656390(+) A-I      intronic chr22:36656366(+) A-I      intronic chr22:36662941(+) A-I      3'UTR chr22:36662916(+) A-I      3'UTR chr22:36662905(+) A-I      3'UTR chr22:36662853(+) A-I      3'UTR chr22:36662349(+) A-I      3'UTR chr22:36662322(+) A-I      3'UTR chr22:36662812(+) A-I      3'UTR chr22:36662262(+) A-I      3'UTR chr22:36662796(+) A-I      3'UTR chr22:36662211(+) A-I      3'UTR chr22:36662201(+) A-I      3'UTR chr22:36662187(+) A-I      3'UTR chr22:36662157(+) A-I      3'UTR chr22:36662705(+) A-I      3'UTR chr22:36662792(+) A-I      3'UTR chr22:36662791(+) A-I      3'UTR chr22:36662766(+) A-I      3'UTR chr22:36662751(+) A-I      3'UTR chr22:36662745(+) A-I      3'UTR chr22:36662358(+) A-I      3'UTR chr22:36662836(+) A-I      3'UTR chr22:36662411(+) A-I      3'UTR chr22:36662732(+) A-I      3'UTR chr22:36662955(+) A-I      3'UTR chr22:36662764(+) A-I      3'UTR chr22:36662278(+) A-I      3'UTR chr22:36662303(+) A-I      3'UTR chr22:36662871(+) A-I      3'UTR chr22:36662697(+) A-I      3'UTR chr22:36662754(+) A-I      3'UTR chr22:36662790(+) A-I      3'UTR chr22:36662800(+) A-I      3'UTR chr22:36662921(+) A-I      3'UTR chr22:36662772(+) A-I      3'UTR chr22:36662935(+) A-I      3'UTR chr22:36662857(+) A-I      3'UTR chr22:36662903(+) A-I      3'UTR chr22:36662862(+) A-I      3'UTR chr22:36662743(+) A-I      3'UTR chr22:36662911(+) A-I      3'UTR chr22:36662892(+) A-I      3'UTR chr22:36662740(+) A-I      3'UTR chr22:36662798(+) A-I      3'UTR chr22:36662217(+) A-I      3'UTR chr22:36662346(+) A-I      3'UTR chr22:36662773(+) A-I      3'UTR chr22:36662396(+) A-I      3'UTR chr22:36662804(+) A-I      3'UTR chr22:36662799(+) A-I      3'UTR chr22:36662263(+) A-I      3'UTR chr22:36662879(+) A-I      3'UTR chr22:36662830(+) A-I      3'UTR chr22:36662840(+) A-I      3'UTR chr22:36662181(+) A-I      3'UTR chr22:36662713(+) A-I      3'UTR chr22:36662946(+) A-I      3'UTR chr22:36662311(+) A-I      3'UTR chr22:36662192(+) A-I      3'UTR chr22:36662241(+) A-I      3'UTR chr22:36662418(+) A-I      3'UTR chr22:36662788(+) A-I      3'UTR chr22:36662735(+) A-I      3'UTR chr22:36662395(+) A-I      3'UTR chr22:36662366(+) A-I      3'UTR chr22:36662374(+) A-I      3'UTR chr22:36662872(+) A-I      3'UTR chr22:36662334(+) A-I      3'UTR chr22:36662801(+) A-I      3'UTR chr22:36662206(+) A-I      3'UTR chr22:36662789(+) A-I      3'UTR chr22:36662320(+) A-I      3'UTR chr22:36662317(+) A-I      3'UTR chr22:36662237(+) A-I      3'UTR chr22:36660958(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	APOL1	chr22:36662696(+) A-I exon 3'UTR    15258596   //16100382   //22028664 chr22:36662697(+) A-I exon 3'UTR    15258596   //22028664   //22327324 chr22:36662735(+) A-I exon 3'UTR    15258596   //22028664 chr22:36662740(+) A-I exon 3'UTR    15258596   //22028664   //22327324 chr22:36662768(+) A-I exon 3'UTR    15258596   //22028664 chr22:36662788(+) A-I exon 3'UTR    15258596   //22028664 chr22:36662161(+) A-I intron -    22327324 chr22:36662181(+) A-I intron -    22327324 chr22:36662193(+) A-I intron -    22327324 chr22:36662266(+) A-I intron -    22327324 chr22:36662276(+) A-I intron -    22327324 chr22:36662298(+) A-I intron -    22327324 chr22:36662317(+) A-I intron -    22327324 chr22:36662318(+) A-I intron -    22327324 chr22:36662366(+) A-I intron -    22327324 chr22:36662374(+) A-I intron -    22327324 chr22:36662382(+) A-I intron -    22327324 chr22:36662396(+) A-I intron -    22327324 chr22:36662397(+) A-I intron -    22327324 chr22:36662409(+) A-I intron -    22327324 chr22:36662797(+) A-I intron -    22028664   //22327324 chr22:36662804(+) A-I intron -    22028664   //22327324 chr22:36662719(+) A-I intron -    22028664 chr22:36662743(+) A-I intron -    22028664 chr22:36662754(+) A-I intron -    22028664 chr22:36662764(+) A-I intron -    22028664 chr22:36662772(+) A-I intron -    22028664 chr22:36662774(+) A-I intron -    22028664 chr22:36662789(+) A-I intron -    22028664 chr22:36662790(+) A-I intron -    22028664 chr22:36662794(+) A-I intron -    22028664 chr22:36662798(+) A-I intron -    22028664 chr22:36662830(+) A-I intron -    22028664   //21960545 chr22:36662840(+) A-I intron -    22028664 chr22:36662857(+) A-I intron -    22028664 chr22:36662862(+) A-I intron -    22028664 chr22:36662863(+) A-I intron -    22028664 chr22:36662871(+) A-I intron -    22028664   //21960545 chr22:36662872(+) A-I intron -    22028664   //21960545 chr22:36662892(+) A-I intron -    22028664 chr22:36662901(+) A-I intron -    22028664 chr22:36662911(+) A-I intron -    22028664 chr22:36662921(+) A-I intron -    22028664 chr22:36662935(+) A-I intron -    22028664 chr22:36662397(+) A-G intron -    21725310   //22484847 chr22:36662161(+) A-G intron -    22484847 chr22:36662181(+) A-G intron -    22484847 chr22:36662193(+) A-G intron -    22484847 chr22:36662206(+) A-G intron -    22484847 chr22:36662217(+) A-G intron -    22484847 chr22:36662236(+) A-G intron -    22484847 chr22:36662237(+) A-G intron -    22484847 chr22:36662263(+) A-G intron -    22484847 chr22:36662266(+) A-G intron -    22484847 chr22:36662276(+) A-G intron -    22484847 chr22:36662278(+) A-G intron -    22484847 chr22:36662298(+) A-G intron -    22484847 chr22:36662302(+) A-G intron -    22484847 chr22:36662311(+) A-G intron -    22484847 chr22:36662317(+) A-G intron -    22484847 chr22:36662318(+) A-G intron -    22484847 chr22:36662334(+) A-G intron -    22484847 chr22:36662337(+) A-G intron -    22484847 chr22:36662346(+) A-G intron -    22484847 chr22:36662366(+) A-G intron -    22484847 chr22:36662374(+) A-G intron -    22484847 chr22:36662382(+) A-G intron -    22484847 chr22:36662396(+) A-G intron -    22484847 chr22:36662409(+) A-G intron -    22484847 chr22:36662418(+) A-G intron -    22484847 chr22:36662696(+) A-G intron -    22484847 chr22:36662697(+) A-G intron -    22484847 chr22:36662702(+) A-G intron -    22484847 chr22:36662719(+) A-G intron -    22484847 chr22:36662740(+) A-G intron -    22484847 chr22:36662774(+) A-G intron -    22484847 chr22:36662788(+) A-G intron -    22484847 chr22:36662797(+) A-G intron -    22484847 chr22:36662800(+) A-G intron -    22484847 chr22:36662801(+) A-G intron -    22484847 chr22:36662804(+) A-G intron -    22484847 chr22:36662830(+) A-G intron -    22484847 chr22:36662840(+) A-G intron -    22484847 chr22:36662841(+) A-G intron -    22484847 chr22:36662863(+) A-G intron -    22484847 chr22:36662871(+) A-G intron -    22484847 chr22:36662872(+) A-G intron -    22484847 chr22:36662879(+) A-G intron -    22484847 chr22:36662901(+) A-G intron -    22484847 chr22:36662903(+) A-G intron -    22484847 chr22:36662933(+) A-G intron -    22484847 chr22:36662946(+) A-G intron -    22484847 chr22:36662950(+) C-A intron -    22484847 chr22:36662952(+) A-G intron -    22484847 chr22:36662957(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	APOL1	chr22:36649158-36649159(+) m6A 5'UTR       24981863 chr22:36649166-36649167(+) m6A 5'UTR       24981863 chr22:36649222-36649223(+) m6A 5'UTR//exon       24981863 chr22:36649906-36649907(+) m6A 5'UTR//exon//intron       24981863 chr22:36649945-36649946(+) m6A 5'UTR//exon//intron       24981863 chr22:36657759-36657760(+) m6A CDS       24209618//24981863 chr22:36661228-36661229(+) m6A CDS       24209618//24981863 chr22:36661241-36661242(+) m6A CDS       24209618//24981863 chr22:36661258-36661259(+) m6A CDS       24209618//24981863 chr22:36661264-36661265(+) m6A CDS       24209618//24981863 chr22:36661294-36661295(+) m6A CDS       24209618//24981863 chr22:36661508-36661509(+) m6A CDS       24209618//24981863//22575960 chr22:36661567-36661568(+) m6A CDS       24209618//24981863//27773535//22575960 chr22:36661587-36661588(+) m6A CDS       24209618//24981863//27773535//22575960 chr22:36661663-36661664(+) m6A CDS       24209618//24981863//22575960 chr22:36661726-36661727(+) m6A CDS       24209618//24981863//22575960 chr22:36661829-36661830(+) m6A CDS       24209618//24981863 chr22:36661850-36661851(+) m6A CDS       24209618//24981863 chr22:36661980-36661981(+) m6A CDS       24209618//24981863//22575960 chr22:36662029-36662030(+) m6A CDS       24209618//24981863//22575960 chr22:36662065-36662066(+) m6A CDS       24209618//24981863//22575960 chr22:36662072-36662073(+) m6A CDS       24209618//24981863//22575960 chr22:36662128-36662129(+) m6A 3'UTR       24209618//24981863//22575960 chr22:36662139-36662140(+) m6A 3'UTR       24209618//24981863//22575960 chr22:36662158-36662159(+) m6A 3'UTR//intron       24209618//24981863 chr22:36662272-36662273(+) m6A 3'UTR//intron       24209618 chr22:36662443-36662444(+) m6A 3'UTR//intron       24209618 chr22:36662487-36662488(+) m6A 3'UTR//intron       24209618//24981863 chr22:36662501-36662502(+) m6A 3'UTR//intron       24209618//24981863 chr22:36662577-36662578(+) m6A 3'UTR//intron       24209618//24981863 chr22:36662609-36662610(+) m6A 3'UTR//intron       24209618//24981863 chr22:36662650-36662651(+) m6A 3'UTR//intron       24209618//24981863 chr22:36662750-36662751(+) m6A 3'UTR//intron       24209618 chr22:36662773-36662774(+) m6A 3'UTR//intron       24209618 chr22:36662871-36662872(+) m6A 3'UTR//intron       24209618 chr22:36662940-36662941(+) m6A 3'UTR       24209618//24981863 chr22:36663006-36663007(+) m6A 3'UTR       24209618//24981863//27773535 chr22:36663067-36663068(+) m6A 3'UTR       24209618//24981863//27773535 chr22:36663089-36663090(+) m6A 3'UTR       24209618//24981863//27773535 chr22:36663107-36663108(+) m6A 3'UTR       24209618//24981863 chr22:36663312-36663313(+) m6A 3'UTR       24981863 chr22:36663376-36663377(+) m6A 3'UTR       24981863 chr22:36663382-36663383(+) m6A 3'UTR       24981863 chr22:36663404-36663405(+) m6A 3'UTR       24981863 chr22:36663418-36663419(+) m6A 3'UTR       24981863 chr22:36663448-36663449(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	APOL1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: APOL1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).