Basic Information:

  VIRBase ID:  

VHID00446507

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          SORBS2:  NM_001145671     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	SORBS2
miRBase Accession/Entrez ID	MIMAT0002186	8470
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARGBP2//PRO0618

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SORBS2	chr4:186580790(-) A-I      intronic chr4:186667653(-) A-I      intronic chr4:186667647(-) A-I      intronic chr4:186557150(-) A-I      intronic chr4:186549734(-) A-I      intronic chr4:186549870(-) A-I      intronic chr4:186689587(-) A-I      intronic chr4:186668964(-) A-I      intronic chr4:186557292(-) A-I      intronic chr4:186569371(-) A-I      intronic chr4:186690809(-) A-I      intronic chr4:186579892(-) A-I      intronic chr4:186692412(-) A-I      intronic chr4:186690895(-) A-I      intronic chr4:186690935(-) A-I      intronic chr4:186692241(-) A-I      intronic chr4:186692382(-) A-I      intronic chr4:186689580(-) A-I      intronic chr4:186692272(-) A-I      intronic chr4:186692273(-) A-I      intronic chr4:186692291(-) A-I      intronic chr4:186692377(-) A-I      intronic chr4:186579950(-) A-I      intronic chr4:186582391(-) A-I      intronic chr4:186582318(-) A-I      intronic chr4:186582172(-) A-I      intronic chr4:186579946(-) A-I      intronic chr4:186667727(-) A-I      intronic chr4:186579963(-) A-I      intronic chr4:186580057(-) A-I      intronic chr4:186580780(-) A-I      intronic chr4:186668978(-) A-I      intronic chr4:186689589(-) A-I      intronic chr4:186558080(-) A-I      intronic chr4:186580847(-) A-I      intronic chr4:186721134(-) A-I      intronic chr4:186668897(-) A-I      intronic chr4:186859231(-) A-I      intronic chr4:186702328(-) A-I      intronic chr4:186692231(-) A-I      intronic chr4:186569489(-) A-I      intronic chr4:186689628(-) A-I      intronic chr4:186692203(-) A-I      intronic chr4:186692275(-) A-I      intronic chr4:186569421(-) A-I      intronic chr4:186863616(-) A-I      intronic chr4:186735441(-) A-I      intronic chr4:186580638(-) A-I      intronic chr4:186689806(-) A-I      intronic chr4:186639125(-) A-I      intronic chr4:186569466(-) A-I      intronic chr4:186708065(-) A-I      intronic chr4:186625681(-) A-I      intronic chr4:186533742(-) A-I      intronic chr4:186692348(-) A-I      intronic chr4:186817675(-) A-I      intronic chr4:186692238(-) A-I      intronic chr4:186617647(-) A-I      intronic chr4:186539237(-) A-I      intronic chr4:186612996(-) A-I      intronic chr4:186817656(-) A-I      intronic chr4:186832556(-) A-I      intronic chr4:186533764(-) A-I      intronic chr4:186832582(-) A-I      intronic chr4:186569334(-) A-I      intronic chr4:186832654(-) A-I      intronic chr4:186580848(-) A-I      intronic chr4:186569465(-) A-I      intronic chr4:186651307(-) A-I      intronic chr4:186668910(-) A-I      intronic chr4:186667744(-) A-I      intronic chr4:186807520(-) A-I      intronic chr4:186669131(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SORBS2	chr4:186550957(-) A-I intron -    21960545 chr4:186550987(-) A-I intron -    21960545 chr4:186569343(-) A-I intron -    21960545 chr4:186569372(-) A-I intron -    21960545 chr4:186569383(-) A-I intron -    21960545 chr4:186569393(-) A-I intron -    21960545 chr4:186569458(-) A-I intron -    21960545 chr4:186569465(-) A-I intron -    21960545 chr4:186569489(-) A-I intron -    21960545 chr4:186569685(-) A-I intron -    21960545 chr4:186609491(-) A-I intron -    21960545 chr4:186609494(-) A-I intron -    21960545 chr4:186609584(-) A-I intron -    21960545 chr4:186609585(-) A-I intron -    21960545 chr4:186609707(-) A-I intron -    21960545 chr4:186609714(-) A-I intron -    21960545 chr4:186609786(-) A-I intron -    21960545 chr4:186609818(-) A-I intron -    21960545 chr4:186689691(-) A-I intron -    21960545 chr4:186692420(-) A-I intron -    21960545 chr4:186699468(-) A-I intron -    21960545 chr4:186699484(-) A-I intron -    21960545 chr4:186699612(-) A-I intron -    21960545 chr4:186717356(-) A-I intron -    21960545 chr4:186517838(-) T-C intron -    22484847 chr4:186651298(-) C-T intron -    22484847 chr4:186651307(-) A-G intron -    22484847 chr4:186669123(-) A-G intron -    22484847 chr4:186863605(-) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SORBS2	chr4:186519639-186519640(-) Am intron       - chr4:186528287-186528288(-) m6A exon//intron       24284625 chr4:186570748-186570749(-) m6A CDS//exon       24981863//27773535 chr4:186570756-186570757(-) m6A CDS//exon       24981863//27773535 chr4:186570762-186570763(-) m6A CDS//exon       24981863//27773535 chr4:186572969-186572970(-) m6A CDS//exon//intron       27773535 chr4:186578740-186578741(-) m6A CDS//exon       24284625//27773535 chr4:186696506-186696507(-) m6A 5'UTR//exon//intron       24284625 chr4:186696519-186696520(-) m6A 5'UTR//exon//intron       24284625 chr4:186854145-186854146(-) m6A exon//intron       - chr4:186854166-186854167(-) m6A exon//intron       - chr4:186854211-186854212(-) m6A exon//intron       - chr4:186854291-186854292(-) m6A exon//intron       - chr4:186854303-186854304(-) m6A exon//intron       - chr4:186854315-186854316(-) m6A exon//intron       - chr4:186854326-186854327(-) m6A exon//intron       - chr4:186854363-186854364(-) m6A exon//intron       - chr4:186854406-186854407(-) m6A exon//intron       - chr4:186854427-186854428(-) m6A exon//intron       - chr4:186854496-186854497(-) m6A exon//intron       - chr4:186854513-186854514(-) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	SORBS2	Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: SORBS2

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).