Basic Information:

  VIRBase ID:  

VHID00446467

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          SORL1:  NM_003105     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	SORL1
miRBase Accession/Entrez ID	MIMAT0002186	6653
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C11orf32//gp250//LR11//LRP9//SORLA//SorLA-1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SORL1	chr11:121432874(+) A-I      intronic chr11:121431708(+) A-I      intronic chr11:121431724(+) A-I      intronic chr11:121431692(+) A-I      intronic chr11:121431691(+) A-I      intronic chr11:121432894(+) A-I      intronic chr11:121364194(+) A-I      intronic chr11:121431730(+) A-I      intronic chr11:121431742(+) A-I      intronic chr11:121431778(+) A-I      intronic chr11:121432854(+) A-I      intronic chr11:121432866(+) A-I      intronic chr11:121432858(+) A-I      intronic chr11:121432862(+) A-I      intronic chr11:121365816(+) A-I      intronic chr11:121455324(+) A-I      intronic chr11:121355738(+) A-I      intronic chr11:121407302(+) A-I      intronic chr11:121362931(+) A-I      intronic chr11:121357549(+) A-I      intronic chr11:121362894(+) A-I      intronic chr11:121407203(+) A-I      intronic chr11:121362886(+) A-I      intronic chr11:121362884(+) A-I      intronic chr11:121357370(+) A-I      intronic chr11:121355486(+) A-I      intronic chr11:121407391(+) A-I      intronic chr11:121403654(+) A-I      intronic chr11:121412155(+) A-I      intronic chr11:121399070(+) A-I      intronic chr11:121347557(+) A-I      intronic chr11:121347710(+) A-I      intronic chr11:121412156(+) A-I      intronic chr11:121403607(+) A-I      intronic chr11:121364066(+) A-I      intronic chr11:121362972(+) A-I      intronic chr11:121456112(+) A-I      intronic chr11:121455937(+) A-I      intronic chr11:121399957(+) A-I      intronic chr11:121400043(+) A-I      intronic chr11:121482783(+) A-I      intronic chr11:121357106(+) A-I      intronic chr11:121386590(+) A-I      intronic chr11:121357093(+) A-I      intronic chr11:121355494(+) A-I      intronic chr11:121361330(+) A-I      intronic chr11:121399088(+) A-I      intronic chr11:121374386(+) A-I      intronic chr11:121456180(+) A-I      intronic chr11:121456014(+) A-I      intronic chr11:121455538(+) A-I      intronic chr11:121413773(+) A-I      intronic chr11:121413753(+) A-I      intronic chr11:121412193(+) A-I      intronic chr11:121413745(+) A-I      intronic chr11:121347763(+) A-I      intronic chr11:121412180(+) A-I      intronic chr11:121412199(+) A-I      intronic chr11:121412153(+) A-I      intronic chr11:121411930(+) A-I      intronic chr11:121411203(+) A-I      intronic chr11:121407257(+) A-I      intronic chr11:121407227(+) A-I      intronic chr11:121403636(+) A-I      intronic chr11:121403481(+) A-I      intronic chr11:121400026(+) A-I      intronic chr11:121400012(+) A-I      intronic chr11:121403593(+) A-I      intronic chr11:121399945(+) A-I      intronic chr11:121389802(+) A-I      intronic chr11:121389726(+) A-I      intronic chr11:121347762(+) A-I      intronic chr11:121387693(+) A-I      intronic chr11:121374251(+) A-I      intronic chr11:121362889(+) A-I      intronic chr11:121373052(+) A-I      intronic chr11:121347626(+) A-I      intronic chr11:121373010(+) A-I      intronic chr11:121364240(+) A-I      intronic chr11:121364227(+) A-I      intronic chr11:121364046(+) A-I      intronic chr11:121363707(+) A-I      intronic chr11:121362976(+) A-I      intronic chr11:121362955(+) A-I      intronic chr11:121361326(+) A-I      intronic chr11:121455332(+) A-I      intronic chr11:121362949(+) A-I      intronic chr11:121375000(+) A-I      intronic chr11:121413777(+) A-I      intronic chr11:121413631(+) A-I      intronic chr11:121373044(+) A-I      intronic chr11:121407222(+) A-I      intronic chr11:121363077(+) A-I      intronic chr11:121375019(+) A-I      intronic chr11:121357115(+) A-I      intronic chr11:121362823(+) A-I      intronic chr11:121364228(+) A-I      intronic chr11:121431675(+) A-I      intronic chr11:121374237(+) A-I      intronic chr11:121411108(+) A-I      intronic chr11:121362793(+) A-I      intronic chr11:121344348(+) A-I      intronic chr11:121347631(+) A-I      intronic chr11:121456049(+) A-I      intronic chr11:121391041(+) A-I      intronic chr11:121482788(+) A-I      intronic chr11:121456179(+) A-I      intronic chr11:121403538(+) A-I      intronic chr11:121411176(+) A-I      intronic chr11:121374956(+) A-I      intronic chr11:121374378(+) A-I      intronic chr11:121362815(+) A-I      intronic chr11:121348621(+) A-I      intronic chr11:121432908(+) A-I      intronic chr11:121431645(+) A-I      intronic chr11:121363872(+) A-I      intronic chr11:121399077(+) A-I      intronic chr11:121407379(+) A-I      intronic chr11:121374903(+) A-I      intronic chr11:121400391(+) A-I      intronic chr11:121361339(+) A-I      intronic chr11:121448269(+) A-I      intronic chr11:121343445(+) A-I      intronic chr11:121496787(+) A-I      intronic chr11:121373632(+) A-I      intronic chr11:121362923(+) A-I      intronic chr11:121432838(+) A-I      intronic chr11:121403576(+) A-I      intronic chr11:121403446(+) A-I      intronic chr11:121411929(+) A-I      intronic chr11:121364024(+) A-I      intronic chr11:121403534(+) A-I      intronic chr11:121364095(+) A-I      intronic chr11:121341526(+) A-I      intronic chr11:121431640(+) A-I      intronic chr11:121496780(+) A-I      intronic chr11:121403464(+) A-I      intronic chr11:121456028(+) A-I      intronic chr11:121362814(+) A-I      intronic chr11:121431641(+) A-I      intronic chr11:121374249(+) A-I      intronic chr11:121373779(+) A-I      intronic chr11:121347753(+) A-I      intronic chr11:121455951(+) A-I      intronic chr11:121411131(+) A-I      intronic chr11:121341581(+) A-I      intronic chr11:121364149(+) A-I      intronic chr11:121357149(+) A-I      intronic chr11:121412011(+) A-I      intronic chr11:121364146(+) A-I      intronic chr11:121448268(+) A-I      intronic chr11:121403573(+) A-I      intronic chr11:121413910(+) A-I      intronic chr11:121413779(+) A-I      intronic chr11:121361357(+) A-I      intronic chr11:121391034(+) A-I      intronic chr11:121470133(+) A-I      intronic chr11:121373036(+) A-I      intronic chr11:121374299(+) A-I      intronic chr11:121496779(+) A-I      intronic chr11:121362820(+) A-I      intronic chr11:121456011(+) A-I      intronic chr11:121391035(+) A-I      intronic chr11:121407308(+) A-I      intronic chr11:121403655(+) A-I      intronic chr11:121357306(+) A-I      intronic chr11:121448359(+) A-I      intronic chr11:121413632(+) A-I      intronic chr11:121398996(+) A-I      intronic chr11:121372876(+) A-I      intronic chr11:121363800(+) A-I      intronic chr11:121390900(+) A-I      intronic chr11:121374974(+) A-I      intronic chr11:121403532(+) A-I      intronic chr11:121434367(+) A-I      intronic chr11:121374868(+) A-I      intronic chr11:121411130(+) A-I      intronic chr11:121411166(+) A-I      intronic chr11:121347640(+) A-I      intronic chr11:121391112(+) A-I      intronic chr11:121407248(+) A-I      intronic chr11:121400385(+) A-I      intronic chr11:121347673(+) A-I      intronic chr11:121364157(+) A-I      intronic chr11:121347554(+) A-I      intronic chr11:121362860(+) A-I      intronic chr11:121403448(+) A-I      intronic chr11:121362959(+) A-I      intronic chr11:121446900(+) A-I      intronic chr11:121496784(+) A-I      intronic chr11:121363821(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SORL1	chr11:121496784(+) A-I intron -    22327324 chr11:121503149(+) A-I intron -    22327324 chr11:121391034(+) A-G intron -    22484847 chr11:121391035(+) A-G intron -    22484847 chr11:121448269(+) A-G intron -    22484847 chr11:121357549(+) A-G intron -    22484847 chr11:121403538(+) A-G intron -    22484847 chr11:121407308(+) A-G intron -    22484847 chr11:121412156(+) A-G intron -    22484847 chr11:121412180(+) A-G intron -    22484847 chr11:121482788(+) A-G intron -    22484847 chr11:121431641(+) A-G intron -    22484847 chr11:121496784(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SORL1	chr11:121323321-121323322(+) m6A CDS//exon       27371828 chr11:121448067-121448068(+) m6A CDS       - chr11:121448082-121448083(+) m6A CDS       - chr11:121483352-121483353(+) m6A exon//intron       - chr11:121483463-121483464(+) m6A CDS//exon       - chr11:121483504-121483505(+) m6A CDS//exon       - chr11:121483511-121483512(+) m6A CDS//exon       - chr11:121485629-121485630(+) m6A CDS//exon       - chr11:121485725-121485726(+) m6A CDS//exon       - chr11:121485746-121485747(+) m6A CDS//exon       - chr11:121500391-121500392(+) m6A 3'UTR//exon//intron       27773535 chr11:121500398-121500399(+) m6A 3'UTR//exon//intron       27773535 chr11:121500434-121500435(+) m6A 3'UTR//intron       27773535 chr11:121500456-121500457(+) m6A 3'UTR//intron       27773535 chr11:121500463-121500464(+) m6A 3'UTR//intron       27773535 chr11:121501392-121501393(+) m6A 3'UTR//intron       - chr11:121501440-121501441(+) m6A 3'UTR//intron       - chr11:121501503-121501504(+) m6A 3'UTR//intron       - chr11:121501554-121501555(+) m6A 3'UTR//intron       - chr11:121503878-121503879(+) m6A 3'UTR       26404942 chr11:121504073-121504074(+) m6A 3'UTR       26404942 chr11:121504114-121504115(+) m6A 3'UTR       24981863//26404942 chr11:121504127-121504128(+) m6A 3'UTR       24981863//26404942 chr11:121504137-121504138(+) m6A 3'UTR       24981863//26404942 chr11:121504203-121504204(+) m6A 3'UTR       26404942//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	SORL1	Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: SORL1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).