Basic Information:

  VIRBase ID:  

VHID00446413

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          MIF:  NM_002415     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	MIF
miRBase Accession/Entrez ID	MIMAT0002186	4282
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	GIF//GLIF//MMIF

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MIF	chr22:24236329-24236330(+) m6A 5'UTR       25456834 chr22:24236339-24236340(+) m6A 5'UTR       25456834 chr22:24236357-24236358(+) m6A 5'UTR       25456834 chr22:24236387-24236388(+) m6A 5'UTR       25456834 chr22:24236564-24236565(+) m6A 5'UTR       24284625//25456834//24981863//26404942//27371828//22575960 chr22:24236660-24236661(+) Cm 5'UTR//exon       - chr22:24236680-24236681(+) m6A CDS//exon       24284625//24981863//27371828//22575960 chr22:24236983-24236984(+) m6A CDS//exon       22575960 chr22:24237048-24237049(+) Am CDS//exon       - chr22:24237067-24237068(+) m6A CDS//exon       22575960 chr22:24237127-24237128(+) m6A CDS//exon       26404942//22575960 chr22:24237187-24237188(+) m6A exon//intron       26404942//22575960 chr22:24237273-24237274(+) m6A CDS//exon       22575960 chr22:24237304-24237305(+) m6A 3'UTR//exon       22575960 chr22:24237336-24237337(+) m6A 3'UTR//exon       22575960 chr22:24237406-24237407(+) m6A 3'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	MIF	Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: MIF

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.