Basic Information:

  VIRBase ID:  

VHID00446364

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          MARK2:  NM_001163297     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	MARK2
miRBase Accession/Entrez ID	MIMAT0002186	2011
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	EMK-1//EMK1//PAR-1//Par-1b//Par1b

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MARK2	chr11:63628207(+) A-I      intronic chr11:63617134(+) A-I      intronic chr11:63617145(+) A-I      intronic chr11:63628164(+) A-I      intronic chr11:63628171(+) A-I      intronic chr11:63628179(+) A-I      intronic chr11:63628285(+) A-I      intronic chr11:63628255(+) A-I      intronic chr11:63627278(+) A-I      intronic chr11:63627243(+) A-I      intronic chr11:63627230(+) A-I      intronic chr11:63627199(+) A-I      intronic chr11:63627127(+) A-I      intronic chr11:63626099(+) A-I      intronic chr11:63625992(+) A-I      intronic chr11:63625943(+) A-I      intronic chr11:63625868(+) A-I      intronic chr11:63624670(+) A-I      intronic chr11:63627293(+) A-I      intronic chr11:63622849(+) A-I      intronic chr11:63622833(+) A-I      intronic chr11:63622832(+) A-I      intronic chr11:63622713(+) A-I      intronic chr11:63622123(+) A-I      intronic chr11:63622097(+) A-I      intronic chr11:63621941(+) A-I      intronic chr11:63621924(+) A-I      intronic chr11:63621722(+) A-I      intronic chr11:63621510(+) A-I      intronic chr11:63621462(+) A-I      intronic chr11:63621394(+) A-I      intronic chr11:63620721(+) A-I      intronic chr11:63620711(+) A-I      intronic chr11:63620706(+) A-I      intronic chr11:63618370(+) A-I      intronic chr11:63617180(+) A-I      intronic chr11:63611944(+) A-I      intronic chr11:63617098(+) A-I      intronic chr11:63617096(+) A-I      intronic chr11:63617075(+) A-I      intronic chr11:63617073(+) A-I      intronic chr11:63617047(+) A-I      intronic chr11:63616969(+) A-I      intronic chr11:63615921(+) A-I      intronic chr11:63615911(+) A-I      intronic chr11:63614550(+) A-I      intronic chr11:63614491(+) A-I      intronic chr11:63614488(+) A-I      intronic chr11:63613274(+) A-I      intronic chr11:63613234(+) A-I      intronic chr11:63609872(+) A-I      intronic chr11:63614462(+) A-I      intronic chr11:63609869(+) A-I      intronic chr11:63609788(+) A-I      intronic chr11:63651169(+) A-I      intronic chr11:63632400(+) A-I      intronic chr11:63644709(+) A-I      intronic chr11:63621625(+) A-I      intronic chr11:63646606(+) A-I      intronic chr11:63637793(+) A-I      intronic chr11:63653490(+) A-I      intronic chr11:63626049(+) A-I      intronic chr11:63611865(+) A-I      intronic chr11:63632140(+) A-I      intronic chr11:63627979(+) A-I      intronic chr11:63620615(+) A-I      intronic chr11:63616528(+) A-I      intronic chr11:63625408(+) A-I      intronic chr11:63628658(+) A-I      intronic chr11:63621789(+) A-I      intronic chr11:63614515(+) A-I      intronic chr11:63613469(+) A-I      intronic chr11:63622845(+) A-I      intronic chr11:63652888(+) A-I      intronic chr11:63629659(+) A-I      intronic chr11:63617069(+) A-I      intronic chr11:63624815(+) A-I      intronic chr11:63653738(+) A-I      intronic chr11:63646615(+) A-I      intronic chr11:63633703(+) A-I      intronic chr11:63616525(+) A-I      intronic chr11:63621811(+) A-I      intronic chr11:63625955(+) A-I      intronic chr11:63642735(+) A-I      intronic chr11:63644766(+) A-I      intronic chr11:63652432(+) A-I      intronic chr11:63615996(+) A-I      intronic chr11:63621607(+) A-I      intronic chr11:63622753(+) A-I      intronic chr11:63626814(+) A-I      intronic chr11:63629577(+) A-I      intronic chr11:63609818(+) A-I      intronic chr11:63622959(+) A-I      intronic chr11:63617035(+) A-I      intronic chr11:63653977(+) A-I      intronic chr11:63653961(+) A-I      intronic chr11:63653928(+) A-I      intronic chr11:63653818(+) A-I      intronic chr11:63653783(+) A-I      intronic chr11:63653781(+) A-I      intronic chr11:63646598(+) A-I      intronic chr11:63625334(+) A-I      intronic chr11:63653638(+) A-I      intronic chr11:63653629(+) A-I      intronic chr11:63652764(+) A-I      intronic chr11:63652625(+) A-I      intronic chr11:63652519(+) A-I      intronic chr11:63652517(+) A-I      intronic chr11:63651342(+) A-I      intronic chr11:63651287(+) A-I      intronic chr11:63651183(+) A-I      intronic chr11:63651156(+) A-I      intronic chr11:63648683(+) A-I      intronic chr11:63648504(+) A-I      intronic chr11:63646691(+) A-I      intronic chr11:63646599(+) A-I      intronic chr11:63633659(+) A-I      intronic chr11:63646552(+) A-I      intronic chr11:63646527(+) A-I      intronic chr11:63645971(+) A-I      intronic chr11:63645091(+) A-I      intronic chr11:63645086(+) A-I      intronic chr11:63645050(+) A-I      intronic chr11:63629275(+) A-I      intronic chr11:63635666(+) A-I      intronic chr11:63633756(+) A-I      intronic chr11:63620791(+) A-I      intronic chr11:63633752(+) A-I      intronic chr11:63633713(+) A-I      intronic chr11:63632221(+) A-I      intronic chr11:63632049(+) A-I      intronic chr11:63629496(+) A-I      intronic chr11:63629564(+) A-I      intronic chr11:63629551(+) A-I      intronic chr11:63629525(+) A-I      intronic chr11:63629500(+) A-I      intronic chr11:63628745(+) A-I      intronic chr11:63626922(+) A-I      intronic chr11:63628636(+) A-I      intronic chr11:63621445(+) A-I      intronic chr11:63611177(+) A-I      intronic chr11:63622854(+) A-I      intronic chr11:63611196(+) A-I      intronic chr11:63653052(+) A-I      intronic chr11:63628183(+) A-I      intronic chr11:63645121(+) A-I      intronic chr11:63622029(+) A-I      intronic chr11:63618814(+) A-I      intronic chr11:63627364(+) A-I      intronic chr11:63648617(+) A-I      intronic chr11:63647169(+) A-I      intronic chr11:63615937(+) A-I      intronic chr11:63621813(+) A-I      intronic chr11:63632501(+) A-I      intronic chr11:63609789(+) A-I      intronic chr11:63617046(+) A-I      intronic chr11:63652846(+) A-I      intronic chr11:63621909(+) A-I      intronic chr11:63629475(+) A-I      intronic chr11:63620797(+) A-I      intronic chr11:63628176(+) A-I      intronic chr11:63634599(+) A-I      intronic chr11:63625432(+) A-I      intronic chr11:63618824(+) A-I      intronic chr11:63644763(+) A-I      intronic chr11:63648622(+) A-I      intronic chr11:63646626(+) A-I      intronic chr11:63632131(+) A-I      intronic chr11:63628665(+) A-I      intronic chr11:63622875(+) A-I      intronic chr11:63614510(+) A-I      intronic chr11:63652742(+) A-I      intronic chr11:63622196(+) A-I      intronic chr11:63632503(+) A-I      intronic chr11:63613384(+) A-I      intronic chr11:63629444(+) A-I      intronic chr11:63653997(+) A-I      intronic chr11:63645122(+) A-I      intronic chr11:63628069(+) A-I      intronic chr11:63633662(+) A-I      intronic chr11:63628223(+) A-I      intronic chr11:63615932(+) A-I      intronic chr11:63618326(+) A-I      intronic chr11:63627056(+) A-I      intronic chr11:63624778(+) A-I      intronic chr11:63625326(+) A-I      intronic chr11:63628720(+) A-I      intronic chr11:63613460(+) A-I      intronic chr11:63628797(+) A-I      intronic chr11:63628704(+) A-I      intronic chr11:63627065(+) A-I      intronic chr11:63652510(+) A-I      intronic chr11:63633599(+) A-I      intronic chr11:63628010(+) A-I      intronic chr11:63617026(+) A-I      intronic chr11:63622092(+) A-I      intronic chr11:63629457(+) A-I      intronic chr11:63629617(+) A-I      intronic chr11:63628245(+) A-I      intronic chr11:63617059(+) A-I      intronic chr11:63646700(+) A-I      intronic chr11:63631289(+) A-I      intronic chr11:63621425(+) A-I      intronic chr11:63626910(+) A-I      intronic chr11:63628173(+) A-I      intronic chr11:63617185(+) A-I      intronic chr11:63622938(+) A-I      intronic chr11:63616307(+) A-I      intronic chr11:63622186(+) A-I      intronic chr11:63614028(+) A-I      intronic chr11:63617104(+) A-I      intronic chr11:63611726(+) A-I      intronic chr11:63631076(+) A-I      intronic chr11:63646102(+) A-I      intronic chr11:63627363(+) A-I      intronic chr11:63644928(+) A-I      intronic chr11:63611762(+) A-I      intronic chr11:63632227(+) A-I      intronic chr11:63621579(+) A-I      intronic chr11:63653643(+) A-I      intronic chr11:63629294(+) A-I      intronic chr11:63611852(+) A-I      intronic chr11:63649314(+) A-I      intronic chr11:63620710(+) A-I      intronic chr11:63609878(+) A-I      intronic chr11:63625919(+) A-I      intronic chr11:63634628(+) A-I      intronic chr11:63622790(+) A-I      intronic chr11:63621395(+) A-I      intronic chr11:63628788(+) A-I      intronic chr11:63622035(+) A-I      intronic chr11:63633774(+) A-I      intronic chr11:63624423(+) A-I      intronic chr11:63653481(+) A-I      intronic chr11:63627173(+) A-I      intronic chr11:63625768(+) A-I      intronic chr11:63646048(+) A-I      intronic chr11:63613734(+) A-I      intronic chr11:63635682(+) A-I      intronic chr11:63633749(+) A-I      intronic chr11:63613275(+) A-I      intronic chr11:63629580(+) A-I      intronic chr11:63621376(+) A-I      intronic chr11:63652753(+) A-I      intronic chr11:63652528(+) A-I      intronic chr11:63611277(+) A-I      intronic chr11:63628864(+) A-I      intronic chr11:63653728(+) A-I      intronic chr11:63622187(+) A-I      intronic chr11:63628661(+) A-I      intronic chr11:63621801(+) A-I      intronic chr11:63611714(+) A-I      intronic chr11:63615994(+) A-I      intronic chr11:63631506(+) A-I      intronic chr11:63621703(+) A-I      intronic chr11:63649331(+) A-I      intronic chr11:63627754(+) A-I      intronic chr11:63621484(+) A-I      intronic chr11:63651174(+) A-I      intronic chr11:63622846(+) A-I      intronic chr11:63613967(+) A-I      intronic chr11:63653131(+) A-I      intronic chr11:63625576(+) A-I      intronic chr11:63653793(+) A-I      intronic chr11:63611307(+) A-I      intronic chr11:63614084(+) A-I      intronic chr11:63625965(+) A-I      intronic chr11:63624784(+) A-I      intronic chr11:63652943(+) A-I      intronic chr11:63616508(+) A-I      intronic chr11:63652890(+) A-I      intronic chr11:63652523(+) A-I      intronic chr11:63627367(+) A-I      intronic chr11:63622073(+) A-I      intronic chr11:63625756(+) A-I      intronic chr11:63616500(+) A-I      intronic chr11:63628209(+) A-I      intronic chr11:63653660(+) A-I      intronic chr11:63625926(+) A-I      intronic chr11:63629571(+) A-I      intronic chr11:63617072(+) A-I      intronic chr11:63653293(+) A-I      intronic chr11:63617078(+) A-I      intronic chr11:63633704(+) A-I      intronic chr11:63609828(+) A-I      intronic chr11:63645067(+) A-I      intronic chr11:63613807(+) A-I      intronic chr11:63628730(+) A-I      intronic chr11:63652936(+) A-I      intronic chr11:63609952(+) A-I      intronic chr11:63613733(+) A-I      intronic chr11:63611769(+) A-I      intronic chr11:63611280(+) A-I      intronic chr11:63617102(+) A-I      intronic chr11:63629594(+) A-I      intronic chr11:63632138(+) A-I      intronic chr11:63635743(+) A-I      intronic chr11:63624675(+) A-I      intronic chr11:63613727(+) A-I      intronic chr11:63644511(+) A-I      intronic chr11:63616597(+) A-I      intronic chr11:63622882(+) A-I      intronic chr11:63653870(+) A-I      intronic chr11:63611195(+) A-I      intronic chr11:63624768(+) A-I      intronic chr11:63620616(+) A-I      intronic chr11:63654118(+) A-I      intronic chr11:63621619(+) A-I      intronic chr11:63617208(+) A-I      intronic chr11:63616996(+) A-I      intronic chr11:63651083(+) A-I      intronic chr11:63613295(+) A-I      intronic chr11:63622213(+) A-I      intronic chr11:63609753(+) A-I      intronic chr11:63631825(+) A-I      intronic chr11:63654057(+) A-I      intronic chr11:63654070(+) A-I      intronic chr11:63617170(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MARK2	chr11:63617102(+) A-G intron -    22484847 chr11:63646598(+) A-G intron -    22484847 chr11:63660402(+) C-T intron -    22484847 chr11:63660412(+) C-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MARK2	chr11:63606993-63606994(+) m6A 5'UTR//CDS       24284625//22575960 chr11:63607021-63607022(+) m6A 5'UTR//CDS       24284625//22575960 chr11:63617461-63617462(+) m6A 5'UTR//intron       24284625 chr11:63668298-63668299(+) m6A CDS       24981863 chr11:63668336-63668337(+) m6A CDS       24981863 chr11:63668347-63668348(+) m6A CDS       24981863 chr11:63668470-63668471(+) m6A CDS       24284625//24981863 chr11:63669695-63669696(+) m6A CDS       24284625 chr11:63670116-63670117(+) m6A CDS       24284625//24981863 chr11:63670156-63670157(+) m6A CDS       24284625//24981863 chr11:63670233-63670234(+) m6A CDS//exon       24284625//24981863 chr11:63670626-63670627(+) m6A CDS//exon//intron       24284625 chr11:63670637-63670638(+) m6A exon//intron       24284625 chr11:63675743-63675744(+) m6A CDS//intron       24284625 chr11:63675757-63675758(+) m6A CDS//intron       24284625 chr11:63676442-63676443(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:63676503-63676504(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676572-63676573(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676603-63676604(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676671-63676672(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676788-63676789(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr11:63677103-63677104(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677112-63677113(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677155-63677156(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677250-63677251(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677898-63677899(+) m6A 3'UTR       24209618 chr11:63678273-63678274(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	MARK2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: MARK2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.