Basic Information:

  VIRBase ID:  

VHID00446362

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:  MIMAT0002186          MEGF9:  NM_001080497     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-8-3p	MEGF9
miRBase Accession/Entrez ID	MIMAT0002186	1955
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	EGFL5

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MEGF9	chr9:123401594(-) A-I      intronic chr9:123401615(-) A-I      intronic chr9:123401691(-) A-I      intronic chr9:123440979(-) A-I      intronic chr9:123444913(-) A-I      intronic chr9:123400423(-) A-I      intronic chr9:123376533(-) A-I      intronic chr9:123378768(-) A-I      intronic chr9:123436889(-) A-I      intronic chr9:123445060(-) A-I      intronic chr9:123376331(-) A-I      intronic chr9:123469013(-) A-I      intronic chr9:123401219(-) A-I      intronic chr9:123432634(-) A-I      intronic chr9:123469012(-) A-I      intronic chr9:123386674(-) A-I      intronic chr9:123386682(-) A-I      intronic chr9:123386685(-) A-I      intronic chr9:123444944(-) A-I      intronic chr9:123399935(-) A-I      intronic chr9:123399942(-) A-I      intronic chr9:123445056(-) A-I      intronic chr9:123386915(-) A-I      intronic chr9:123386778(-) A-I      intronic chr9:123386752(-) A-I      intronic chr9:123412464(-) A-I      intronic chr9:123387068(-) A-I      intronic chr9:123401134(-) A-I      intronic chr9:123412463(-) A-I      intronic chr9:123406274(-) A-I      intronic chr9:123386543(-) A-I      intronic chr9:123444920(-) A-I      intronic chr9:123444932(-) A-I      intronic chr9:123437700(-) A-I      intronic chr9:123440907(-) A-I      intronic chr9:123437698(-) A-I      intronic chr9:123386638(-) A-I      intronic chr9:123437697(-) A-I      intronic chr9:123437667(-) A-I      intronic chr9:123399946(-) A-I      intronic chr9:123401206(-) A-I      intronic chr9:123457773(-) A-I      intronic chr9:123446134(-) A-I      intronic chr9:123386733(-) A-I      intronic chr9:123474314(-) A-I      intronic chr9:123391416(-) A-I      intronic chr9:123391537(-) A-I      intronic chr9:123392027(-) A-I      intronic chr9:123392048(-) A-I      intronic chr9:123392209(-) A-I      intronic chr9:123398488(-) A-I      intronic chr9:123398489(-) A-I      intronic chr9:123400396(-) A-I      intronic chr9:123406192(-) A-I      intronic chr9:123401704(-) A-I      intronic chr9:123468847(-) A-I      intronic chr9:123364464(-) A-I      3'UTR chr9:123364476(-) A-I      3'UTR chr9:123364477(-) A-I      3'UTR chr9:123364485(-) A-I      3'UTR chr9:123386986(-) A-I      intronic chr9:123437904(-) A-I      intronic chr9:123386563(-) A-I      intronic chr9:123391955(-) A-I      intronic chr9:123415787(-) A-I      intronic chr9:123400373(-) A-I      intronic chr9:123401686(-) A-I      intronic chr9:123448540(-) A-I      intronic chr9:123400482(-) A-I      intronic chr9:123398410(-) A-I      intronic chr9:123401187(-) A-I      intronic chr9:123446122(-) A-I      intronic chr9:123472070(-) A-I      intronic chr9:123376489(-) A-I      intronic chr9:123406111(-) A-I      intronic chr9:123391421(-) A-I      intronic chr9:123378001(-) A-I      intronic chr9:123364360(-) A-I      3'UTR chr9:123364373(-) A-I      3'UTR chr9:123364390(-) A-I      3'UTR chr9:123364461(-) A-I      3'UTR chr9:123440965(-) A-I      intronic chr9:123400521(-) A-I      intronic chr9:123386700(-) A-I      intronic chr9:123376404(-) A-I      intronic chr9:123412351(-) A-I      intronic chr9:123414027(-) A-I      intronic chr9:123376398(-) A-I      intronic chr9:123464072(-) A-I      intronic chr9:123376413(-) A-I      intronic chr9:123437085(-) A-I      intronic chr9:123386553(-) A-I      intronic chr9:123368195(-) A-I      intronic chr9:123399887(-) A-I      intronic chr9:123463103(-) A-I      intronic chr9:123436985(-) A-I      intronic chr9:123378166(-) A-I      intronic chr9:123438464(-) A-I      intronic chr9:123438465(-) A-I      intronic chr9:123434650(-) A-I      intronic chr9:123415788(-) A-I      intronic chr9:123401662(-) A-I      intronic chr9:123412486(-) A-I      intronic chr9:123386785(-) A-I      intronic chr9:123448552(-) A-I      intronic chr9:123400469(-) A-I      intronic chr9:123386933(-) A-I      intronic chr9:123391539(-) A-I      intronic chr9:123387334(-) A-I      intronic chr9:123440953(-) A-I      intronic chr9:123400412(-) A-I      intronic chr9:123459633(-) A-I      intronic chr9:123391490(-) A-I      intronic chr9:123400410(-) A-I      intronic chr9:123400400(-) A-I      intronic chr9:123378024(-) A-I      intronic chr9:123377405(-) A-I      intronic chr9:123401234(-) A-I      intronic chr9:123400354(-) A-I      intronic chr9:123387305(-) A-I      intronic chr9:123401569(-) A-I      intronic chr9:123368405(-) A-I      intronic chr9:123401590(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MEGF9	chr9:123363533(-) A-I exon 3'UTR    15342557 chr9:123364205(-) A-I exon 3'UTR    15342557 chr9:123364360(-) A-I exon 3'UTR    15342557 chr9:123364373(-) A-I exon 3'UTR    15342557 chr9:123364390(-) A-I exon 3'UTR    15342557 chr9:123364416(-) A-I exon 3'UTR    15342557 chr9:123364426(-) A-I exon 3'UTR    15342557

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MEGF9	chr9:123366953-123366954(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr9:123367017-123367018(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr9:123367056-123367057(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr9:123367070-123367071(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr9:123367090-123367091(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22608085 chr9:123367101-123367102(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367163-123367164(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367184-123367185(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367204-123367205(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367230-123367231(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367259-123367260(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367399-123367400(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367421-123367422(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367439-123367440(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367457-123367458(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367603-123367604(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367622-123367623(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367641-123367642(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367648-123367649(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367745-123367746(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr9:123367777-123367778(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr9:123367805-123367806(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr9:123370068-123370069(-) m6A CDS       24284625//24981863//27773535 chr9:123370144-123370145(-) m6A CDS       24284625//24981863 chr9:123476122-123476123(-) m6A CDS       24284625//24981863 chr9:123476210-123476211(-) m6A CDS       24284625//27773536 chr9:123476306-123476307(-) m6A CDS       24284625//27371828//27773536 chr9:123476332-123476333(-) m6A CDS       24284625//27371828//27773536 chr9:123476398-123476399(-) m6A CDS       24284625//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	kshv-miR-K12-8-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	MEGF9	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-8-3p
Interactor2: MEGF9

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).