Detail Information

Basic Information:


  VIRBase ID:  

VHID00446337

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-8-3p:           KRIT1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-8-3p KRIT1
miRBase
Accession/Entrez ID		 MIMAT0002186 889
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - CAM//CCM1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KRIT1
chr7:91839205(-) A-I      intronic
chr7:91854415(-) A-I      intronic
chr7:91854404(-) A-I      intronic
chr7:91854384(-) A-I      intronic
chr7:91850684(-) A-I      intronic
chr7:91850677(-) A-I      intronic
chr7:91857389(-) A-I      intronic
chr7:91850670(-) A-I      intronic
chr7:91850117(-) A-I      intronic
chr7:91850587(-) A-I      intronic
chr7:91850545(-) A-I      intronic
chr7:91850173(-) A-I      intronic
chr7:91850114(-) A-I      intronic
chr7:91848534(-) A-I      intronic
chr7:91848511(-) A-I      intronic
chr7:91864472(-) A-I      intronic
chr7:91864420(-) A-I      intronic
chr7:91864411(-) A-I      intronic
chr7:91864410(-) A-I      intronic
chr7:91862244(-) A-I      intronic
chr7:91862188(-) A-I      intronic
chr7:91862187(-) A-I      intronic
chr7:91862146(-) A-I      intronic
chr7:91862140(-) A-I      intronic
chr7:91848447(-) A-I      intronic
chr7:91857244(-) A-I      intronic
chr7:91857207(-) A-I      intronic
chr7:91857154(-) A-I      intronic
chr7:91857020(-) A-I      intronic
chr7:91854797(-) A-I      intronic
chr7:91829880(-) A-I      3'UTR
chr7:91829933(-) A-I      3'UTR
chr7:91829912(-) A-I      3'UTR
chr7:91829835(-) A-I      3'UTR
chr7:91829745(-) A-I      3'UTR
chr7:91829861(-) A-I      3'UTR
chr7:91829741(-) A-I      3'UTR
chr7:91829860(-) A-I      3'UTR
chr7:91829845(-) A-I      3'UTR
chr7:91829839(-) A-I      3'UTR
chr7:91829698(-) A-I      3'UTR
chr7:91829837(-) A-I      3'UTR
chr7:91829699(-) A-I      3'UTR
chr7:91829796(-) A-I      3'UTR
chr7:91829870(-) A-I      3'UTR
chr7:91829783(-) A-I      3'UTR
chr7:91829758(-) A-I      3'UTR
chr7:91829726(-) A-I      3'UTR
chr7:91850124(-) A-I      intronic
chr7:91854766(-) A-I      intronic
chr7:91847773(-) A-I      intronic
chr7:91847893(-) A-I      intronic
chr7:91847770(-) A-I      intronic
chr7:91864352(-) A-I      intronic
chr7:91850644(-) A-I      intronic
chr7:91856964(-) A-I      intronic
chr7:91833312(-) A-I      intronic
chr7:91854410(-) A-I      intronic
chr7:91857169(-) A-I      intronic
chr7:91854244(-) A-I      intronic
chr7:91848602(-) A-I      intronic
chr7:91856720(-) A-I      intronic
chr7:91850558(-) A-I      intronic
chr7:91844817(-) A-I      intronic
chr7:91862859(-) A-I      intronic
chr7:91857163(-) A-I      intronic
chr7:91847780(-) A-I      intronic
chr7:91854735(-) A-I      intronic
chr7:91854786(-) A-I      intronic
chr7:91869022(-) A-I      intronic
chr7:91857013(-) A-I      intronic
chr7:91862858(-) A-I      intronic
chr7:91841367(-) A-I      intronic
chr7:91850275(-) A-I      intronic
chr7:91847823(-) A-I      intronic
chr7:91850707(-) A-I      intronic
chr7:91848443(-) A-I      intronic
chr7:91829886(-) A-I      3'UTR
chr7:91829843(-) A-I      3'UTR
chr7:91829806(-) A-I      3'UTR
chr7:91829849(-) A-I      3'UTR
chr7:91829805(-) A-I      3'UTR
chr7:91829832(-) A-I      3'UTR
chr7:91829836(-) A-I      3'UTR
chr7:91829776(-) A-I      3'UTR
chr7:91829767(-) A-I      3'UTR
chr7:91829841(-) A-I      3'UTR
chr7:91829808(-) A-I      3'UTR
chr7:91829766(-) A-I      3'UTR
chr7:91829883(-) A-I      3'UTR
chr7:91829938(-) A-I      3'UTR
chr7:91829761(-) A-I      3'UTR
chr7:91829737(-) A-I      3'UTR
chr7:91829897(-) A-I      3'UTR
chr7:91829729(-) A-I      3'UTR
chr7:91829893(-) A-I      3'UTR
chr7:91829838(-) A-I      3'UTR
chr7:91829793(-) A-I      3'UTR
chr7:91862172(-) A-I      intronic
chr7:91850085(-) A-I      intronic
chr7:91848509(-) A-I      intronic
chr7:91847802(-) A-I      intronic
chr7:91854312(-) A-I      intronic
chr7:91857243(-) A-I      intronic
chr7:91857042(-) A-I      intronic
chr7:91848484(-) A-I      intronic
chr7:91857017(-) A-I      intronic
chr7:91844912(-) A-I      intronic
chr7:91850197(-) A-I      intronic
chr7:91854313(-) A-I      intronic
chr7:91854842(-) A-I      intronic
chr7:91854795(-) A-I      intronic
chr7:91847490(-) A-I      intronic
chr7:91857019(-) A-I      intronic
chr7:91834577(-) A-I      intronic
chr7:91850641(-) A-I      intronic
chr7:91850505(-) A-I      intronic
chr7:91844881(-) A-I      intronic
chr7:91848489(-) A-I      intronic
chr7:91850098(-) A-I      intronic
chr7:91845480(-) A-I      intronic
chr7:91854760(-) A-I      intronic
chr7:91850222(-) A-I      intronic
chr7:91847670(-) A-I      intronic
chr7:91857026(-) A-I      intronic
chr7:91854674(-) A-I      intronic
chr7:91834849(-) A-I      intronic
chr7:91847597(-) A-I      intronic
chr7:91834495(-) A-I      intronic
chr7:91856927(-) A-I      intronic
chr7:91856729(-) A-I      intronic
chr7:91857071(-) A-I      intronic
chr7:91850269(-) A-I      intronic
chr7:91850145(-) A-I      intronic
chr7:91850274(-) A-I      intronic
chr7:91854349(-) A-I      intronic
chr7:91850653(-) A-I      intronic
chr7:91850667(-) A-I      intronic
chr7:91862885(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED KRIT1
chr7:91829766(-) A-I exon 3'UTR    15342557
chr7:91829767(-) A-I exon 3'UTR    15342557
chr7:91829832(-) A-I exon 3'UTR    15342557
chr7:91829836(-) A-I exon 3'UTR    15342557
chr7:91829897(-) A-I exon 3'UTR    15342557
chr7:91833409(-) A-I intron -    21960545   //22327324
chr7:91833403(-) A-I intron -    21960545
chr7:91833992(-) A-I intron -    21960545
chr7:91833992(-) A-G intron -    22484847
chr7:91829737(-) A-G exon 3'UTR    22484847
chr7:91829761(-) A-G exon 3'UTR    22484847
chr7:91829767(-) A-G exon 3'UTR    22484847
chr7:91829806(-) A-G exon 3'UTR    22484847
chr7:91829808(-) A-G exon 3'UTR    22484847
chr7:91829844(-) A-G exon 3'UTR    22484847
chr7:91829885(-) A-G exon 3'UTR    22484847
chr7:91829886(-) A-G exon 3'UTR    22484847
chr7:91829897(-) A-G exon 3'UTR    22484847
chr7:91833403(-) A-G intron -    22484847
chr7:91833409(-) A-G intron -    22484847
chr7:91833577(-) C-T intron -    22484847
chr7:91833579(-) T-C intron -    22484847
chr7:91834490(-) G-T intron -    22484847
chr7:91845456(-) A-G intron -    22484847
chr7:91848439(-) A-G intron -    22484847
chr7:91848443(-) A-G intron -    22484847
chr7:91848509(-) A-G intron -    22484847
chr7:91850085(-) A-G intron -    22484847
chr7:91850098(-) A-G intron -    22484847
chr7:91850123(-) A-G intron -    22484847
chr7:91850124(-) A-G intron -    22484847
chr7:91850145(-) A-G intron -    22484847
chr7:91850197(-) A-G intron -    22484847
chr7:91850207(-) A-G intron -    22484847
chr7:91850222(-) A-G intron -    22484847
chr7:91850269(-) A-G intron -    22484847
chr7:91850274(-) A-G intron -    22484847
chr7:91850275(-) A-G intron -    22484847
chr7:91850493(-) A-G intron -    22484847
chr7:91850558(-) A-G intron -    22484847
chr7:91850641(-) A-G intron -    22484847
chr7:91850644(-) A-G intron -    22484847
chr7:91850653(-) A-G intron -    22484847
chr7:91850667(-) A-G intron -    22484847
chr7:91850693(-) A-G intron -    22484847
chr7:91850746(-) A-G intron -    22484847
chr7:91854244(-) A-G intron -    22484847
chr7:91854312(-) A-G intron -    22484847
chr7:91854323(-) A-G intron -    22484847
chr7:91854410(-) A-G intron -    22484847
chr7:91854735(-) A-G intron -    22484847
chr7:91854760(-) A-G intron -    22484847
chr7:91854766(-) A-G intron -    22484847
chr7:91854795(-) A-G intron -    22484847
chr7:91856927(-) A-G intron -    22484847
chr7:91856964(-) A-G intron -    22484847
chr7:91857017(-) A-G intron -    22484847
chr7:91857169(-) A-G intron -    22484847
chr7:91857214(-) A-G intron -    22484847
chr7:91857243(-) A-G intron -    22484847
chr7:91857349(-) A-C intron -    22484847
chr7:91857419(-) A-G intron -    22484847
chr7:91857441(-) A-G intron -    22484847
chr7:91862172(-) A-G intron -    22484847
chr7:91862176(-) A-G intron -    22484847
chr7:91864352(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KRIT1
chr7:91829004-91829005(-) m6A 3'UTR//exon       27773535
chr7:91829049-91829050(-) m6A 3'UTR//exon       27773535
chr7:91829098-91829099(-) m6A 3'UTR//exon       27773535
chr7:91829304-91829305(-) m6A 3'UTR//exon       27773535
chr7:91829327-91829328(-) m6A 3'UTR//exon       27773535
chr7:91829490-91829491(-) m6A 3'UTR//exon       27773535
chr7:91829529-91829530(-) m6A 3'UTR//exon       27773535
chr7:91842607-91842608(-) m6A 3'UTR//CDS//exon       27773535
chr7:91843231-91843232(-) m6A 3'UTR//CDS//exon       27773535
chr7:91855036-91855037(-) m6A CDS//exon//intron       27773535
chr7:91855082-91855083(-) m6A CDS//exon//intron       24981863//27773535
chr7:91855091-91855092(-) m6A CDS//exon//intron       24981863//27773535
chr7:91855130-91855131(-) m6A CDS//exon//intron       24981863//27773535
chr7:91855858-91855859(-) m6A CDS//exon       24981863//27773535
chr7:91855887-91855888(-) m6A CDS//exon       24981863//27773535
chr7:91855926-91855927(-) m6A CDS//exon       27773535
chr7:91855939-91855940(-) m6A CDS//exon       27773535
chr7:91864124-91864125(-) m6A CDS//exon       24981863
chr7:91864165-91864166(-) m6A CDS//exon       24981863
chr7:91864190-91864191(-) m6A CDS//exon       24981863
chr7:91874296-91874297(-) m6A 5'UTR//exon//intron       24981863
chr7:91874309-91874310(-) m6A 5'UTR//exon//intron       24981863
chr7:91875037-91875038(-) m6A 5'UTR//exon//intron       24209618//24981863//27371828//27773536
chr7:91875074-91875075(-) m6A 5'UTR//exon//intron       24209618//24981863//27371828//27773536
chr7:91875116-91875117(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828//22608085
chr7:91875177-91875178(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828//22608085
chr7:91875184-91875185(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828//22608085
chr7:91875243-91875244(-) m6A 5'UTR       25456834//24981863
chr7:91875339-91875340(-) m6A 5'UTR       24284625//25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate kshv-miR-K12-8-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
KRIT1
Chromatin K562 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-8-3p
Interactor2: KRIT1

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 22174674 Target region None
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line EA.hy926 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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