Basic Information:

  VIRBase ID:  

VHID00446186

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-3p:  MIMAT0002185          FAM102B:  NM_001010883     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-9-3p	FAM102B
miRBase Accession/Entrez ID	MIMAT0002185	284611
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	SYM-3B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM102B	chr1:109137570(+) A-I      intronic chr1:109137571(+) A-I      intronic chr1:109138522(+) A-I      intronic chr1:109138527(+) A-I      intronic chr1:109158314(+) A-I      intronic chr1:109138563(+) A-I      intronic chr1:109138565(+) A-I      intronic chr1:109138568(+) A-I      intronic chr1:109138631(+) A-I      intronic chr1:109138569(+) A-I      intronic chr1:109137534(+) A-I      intronic chr1:109138578(+) A-I      intronic chr1:109138605(+) A-I      intronic chr1:109138606(+) A-I      intronic chr1:109138666(+) A-I      intronic chr1:109138629(+) A-I      intronic chr1:109158322(+) A-I      intronic chr1:109158327(+) A-I      intronic chr1:109158335(+) A-I      intronic chr1:109158385(+) A-I      intronic chr1:109138632(+) A-I      intronic chr1:109138628(+) A-I      intronic chr1:109137533(+) A-I      intronic chr1:109163414(+) A-I      intronic chr1:109138660(+) A-I      intronic chr1:109138640(+) A-I      intronic chr1:109138639(+) A-I      intronic chr1:109138634(+) A-I      intronic chr1:109112075(+) A-I      intronic chr1:109137560(+) A-I      intronic chr1:109110562(+) A-I      intronic chr1:109110629(+) A-I      intronic chr1:109115312(+) A-I      intronic chr1:109115338(+) A-I      intronic chr1:109115355(+) A-I      intronic chr1:109118704(+) A-I      intronic chr1:109135651(+) A-I      intronic chr1:109135659(+) A-I      intronic chr1:109136575(+) A-I      intronic chr1:109139438(+) A-I      intronic chr1:109139447(+) A-I      intronic chr1:109141488(+) A-I      intronic chr1:109142575(+) A-I      intronic chr1:109142605(+) A-I      intronic chr1:109165647(+) A-I      intronic chr1:109166046(+) A-I      intronic chr1:109166088(+) A-I      intronic chr1:109174474(+) A-I      intronic chr1:109174481(+) A-I      intronic chr1:109174507(+) A-I      intronic chr1:109174534(+) A-I      intronic chr1:109174701(+) A-I      intronic chr1:109174758(+) A-I      intronic chr1:109175442(+) A-I      intronic chr1:109175445(+) A-I      intronic chr1:109175537(+) A-I      intronic chr1:109175966(+) A-I      intronic chr1:109176006(+) A-I      intronic chr1:109115341(+) A-I      intronic chr1:109107379(+) A-I      intronic chr1:109175443(+) A-I      intronic chr1:109165615(+) A-I      intronic chr1:109107465(+) A-I      intronic chr1:109177300(+) A-I      intronic chr1:109136569(+) A-I      intronic chr1:109177174(+) A-I      intronic chr1:109136669(+) A-I      intronic chr1:109166018(+) A-I      intronic chr1:109117208(+) A-I      intronic chr1:109166019(+) A-I      intronic chr1:109145508(+) A-I      intronic chr1:109125900(+) A-I      intronic chr1:109176049(+) A-I      intronic chr1:109177222(+) A-I      intronic chr1:109174657(+) A-I      intronic chr1:109110418(+) A-I      intronic chr1:109166315(+) A-I      intronic chr1:109165595(+) A-I      intronic chr1:109112018(+) A-I      intronic chr1:109137433(+) A-I      intronic chr1:109138405(+) A-I      intronic chr1:109176010(+) A-I      intronic chr1:109177196(+) A-I      intronic chr1:109174721(+) A-I      intronic chr1:109174615(+) A-I      intronic chr1:109117211(+) A-I      intronic chr1:109166006(+) A-I      intronic chr1:109176043(+) A-I      intronic chr1:109136505(+) A-I      intronic chr1:109177236(+) A-I      intronic chr1:109110519(+) A-I      intronic chr1:109166313(+) A-I      intronic chr1:109138484(+) A-I      intronic chr1:109112078(+) A-I      intronic chr1:109149499(+) A-I      intronic chr1:109174480(+) A-I      intronic chr1:109166423(+) A-I      intronic chr1:109165631(+) A-I      intronic chr1:109174616(+) A-I      intronic chr1:109141664(+) A-I      intronic chr1:109142539(+) A-I      intronic chr1:109136507(+) A-I      intronic chr1:109138485(+) A-I      intronic chr1:109136502(+) A-I      intronic chr1:109110388(+) A-I      intronic chr1:109175235(+) A-I      intronic chr1:109165882(+) A-I      intronic chr1:109107389(+) A-I      intronic chr1:109172670(+) A-I      intronic chr1:109165994(+) A-I      intronic chr1:109110509(+) A-I      intronic chr1:109172701(+) A-I      intronic chr1:109112049(+) A-I      intronic chr1:109180813(+) A-I      3'UTR chr1:109174686(+) A-I      intronic chr1:109136567(+) A-I      intronic chr1:109176011(+) A-I      intronic chr1:109175492(+) A-I      intronic chr1:109165974(+) A-I      intronic chr1:109175935(+) A-I      intronic chr1:109177218(+) A-I      intronic chr1:109165914(+) A-I      intronic chr1:109165867(+) A-I      intronic chr1:109166023(+) A-I      intronic chr1:109166411(+) A-I      intronic chr1:109166037(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM102B	chr1:109136502(+) A-G intron -    22484847 chr1:109136505(+) A-G intron -    22484847 chr1:109136507(+) A-G intron -    22484847 chr1:109149499(+) A-G intron -    22484847 chr1:109165595(+) A-G intron -    22484847 chr1:109166037(+) A-G intron -    22484847 chr1:109166315(+) A-G intron -    22484847 chr1:109176010(+) A-G intron -    22484847 chr1:109176011(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM102B	chr1:109171197-109171198(+) m6A CDS//exon       24981863 chr1:109171310-109171311(+) m6A CDS//exon       24981863 chr1:109172216-109172217(+) m6A CDS//exon       24284625 chr1:109177750-109177751(+) m6A CDS//exon//intron       24284625//24209618//22608085 chr1:109177789-109177790(+) m6A 3'UTR//exon//intron       24284625//24209618//22608085 chr1:109177864-109177865(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22608085 chr1:109177912-109177913(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22608085 chr1:109177947-109177948(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22608085 chr1:109178053-109178054(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr1:109178070-109178071(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr1:109178178-109178179(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr1:109178200-109178201(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr1:109178469-109178470(+) m6A 3'UTR//exon//intron       24981863 chr1:109178494-109178495(+) m6A 3'UTR//exon//intron       24981863 chr1:109180365-109180366(+) Gm 3'UTR//exon//intron       - chr1:109180720-109180721(+) m6A 3'UTR//exon//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FAM102B	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-9-3p
Interactor2: FAM102B

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//PITA//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).